Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer

Journal of Clinical Investigation

Volumn 125, Issue 7, 2015, Pages 2891-2903

  Ou, Jingxing ^a   Vijayasarathy, Camasamudram ^b   Ziccardi, Lucia ^b,c   Chen, Shan ^a   Zeng, Yong ^b   Marangoni, Dario ^b   Pope, Jodie G ^a,d   Bush, Ronald A ^b   Wu, Zhijian ^a   Li, Wei ^a   Sieving, Paul A ^a,b  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^c IRCCS FONDAZIONE BIETTI   (Italy)

^d NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR 6; RETINOSCHISIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; CELL ADHESION MOLECULE; EYE PROTEIN; METABOTROPIC RECEPTOR; RS1H PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM1 PROTEIN, MOUSE;

ADENO ASSOCIATED VIRUS 8; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE TRANSFER; MEMBRANE STEADY POTENTIAL; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL PLASTICITY; NIGHT BLINDNESS; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RECEPTOR POTENTIAL; RETINOSCHISIS; SIGNAL TRANSDUCTION; SYNAPSE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; DEFICIENCY; DEPENDOPARVOVIRUS; DISEASE MODEL; ELECTRORETINOGRAPHY; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHOTORECEPTOR CELL; PROCEDURES;

ANIMALS; CALCIUM SIGNALING; CELL ADHESION MOLECULES; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EYE PROTEINS; GENETIC THERAPY; GENETIC VECTORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONAL PLASTICITY; PHOTORECEPTOR CELLS, VERTEBRATE; RECEPTORS, METABOTROPIC GLUTAMATE; RETINOSCHISIS; SYNAPSES; TRPM CATION CHANNELS;

EID: 84936797218     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI81380     Document Type: Article

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