Retinoschisin is a peripheral membrane protein with affinity for anionic phospholipids and affected by divalent cations

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 3, 2007, Pages 991-1000

  Vijayasarathy, Camasamudram ^a   Takada, Yuichiro ^a   Zeng, Yong ^a   Bush, Ronald A ^a   Sieving, Paul A ^a,b  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISCOIDIN; DIVALENT CATION; GLUTATHIONE TRANSFERASE; GLYCEROPHOSPHOLIPID; MEMBRANE PROTEIN; PHOSPHOLIPID; RETINOSCHISIN; TRITON X 114; UNCLASSIFIED DRUG; ANION; CELL ADHESION MOLECULE; EYE PROTEIN; HYBRID PROTEIN; MEMBRANE LIPID; RS1H PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; IMMUNOBLOTTING; IMMUNOGOLD ELECTRON MICROSCOPY; MOUSE; NONHUMAN; PH MEASUREMENT; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEOMICS; RETINA; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; C57BL MOUSE; CELL MEMBRANE; IMMUNOELECTRON MICROSCOPY; METABOLISM; PHOTORECEPTOR; POLYACRYLAMIDE GEL ELECTROPHORESIS; RETINOSCHISIS; THIN LAYER CHROMATOGRAPHY; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; ANIONS; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CELL MEMBRANE; CENTRIFUGATION, DENSITY GRADIENT; CHROMATOGRAPHY, THIN LAYER; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EYE PROTEINS; GLUTATHIONE TRANSFERASE; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, IMMUNOELECTRON; PHOSPHOLIPIDS; PHOTORECEPTORS, VERTEBRATE; RECOMBINANT FUSION PROTEINS; RETINOSCHISIS; SUBCELLULAR FRACTIONS;

EID: 34047265314     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0915     Document Type: Article

References (32)

1. Sauer CG, Gehrig A, Warneke-Wittstock R, et al. Positional cloning of the gene associated with X-linked juvenile retinoschisis. Nat Genet. 1997;17:164-170.
2. Takada Y, Fariss RN, Møller M, et al. Retinoschisin expression and localization in rodent and human pineal and consequences of mouse RS1 gene knockout. Mol Vis. 2006;In Press.
3. Weber BH, Schrewe H, Molday LL, et al. Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure. Proc Natl Acad Sci USA. 2002;99:6222-6227.
4. Mooy CM, Van Den Born LI, Baarsma S, et al. Hereditary X-linked juvenile retinoschisis: a review of the role of Müller cells. Arch Ophthalmol. 2002;120:979-984.
5. Sieving PA. Juvenile retinoschisis. In: Traboulsi E, ed, Genetic Diseases of the Eye. New York: Oxford University Press; 1999:347-356.
6. Zeng Y, Takada Y, Kjellstrom S, et al. RS-1 gene delivery to an adult Rs1h knockout mouse model restores ERG b-wave with reversal of the electronegative waveform of X-linked retinoschisis. Invest Ophthalmol Vis Sci. 2004;45:3279-3285.
7. Molday LL, Hicks D, Sauer CG, Weber BH, Molday RS. Expression of X-linked retinoschisis protein RS1 in photoreceptor and bipolar cells. Invest Ophthalmol Vis Sci. 2001;42:816-825.
8. Molday RS. Focus on molecules: retinoschisin (RS1). Exp Eye Res. 2006.
9. Reid SN, Yamashita C, Farber DB. Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and Müller cells. J Neurosci. 2003;23:6030-6040.
10. Vijayasarathy C, Gawinowicz MA, Zeng Y, Takada Y, Bush RA, Sieving PA. Identification and characterization of two mature isoforms of retinoschisin in murine retina. Biochem Biophys Res Commun. 2006;349:99-105.
11. Wu WW, Wong JP, Kast J, Molday RS. RS1, a discoidin domain-containing retinal cell adhesion protein associated with X-linked retinoschisis, exists as a novel disulfide-linked octamer. J Biol Chem. 2005;280:10721-10730.
12. Reid SN, Farber DB. Glial transcytosis of a photoreceptor-secreted signaling protein, retinoschisin. Glia. 2005;49:397-406.
13. Takada Y, Fariss RN, Tanikawa A, et al. A retinal neuronal developmental wave of retinoschisin expression begins in ganglion cells during layer formation. Invest Ophthalmol Vis Sci. 2004;45:3302-3312.
14. Vogel W. Discoidin domain receptors: structural relations and functional implications. FASEB J. 1999;13(suppl):S77-S82.
15. Rajala RV, McClellan ME, Ash JD, Anderson RE. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. J Biol Chem. 2002;277:43319-43326.
16. Zhang CX, Rothwell WF, Sullivan W, Hsieh TS. Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane associated and hyperphosphorylated, Mol Biol Cell. 2000;11:1011-1022.
17. Cikaluk DE, Tahbaz N, Hendricks LC, et al. GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation. Mol Biol Cell. 1999;10:3357-3372.
18. Babiychuk EB, Draeger A. Annexins in cell membrane dynamics. Ca(2+)-regulated association of lipid microdomains. J Cell Biol. 2000;150:1113-1124.
19. Bordier C. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol Chem. 1981;256:1604-1607.
20. Mahadevappa VG, Holub BJ. The molecular species composition of individual diacyl phospholipids in human platelets. Biochim Biophys Acta. 1982;713:73-79.
21. Gilbert GE, Drinkwater D. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine. Biochemistry. 1993;32:9577-9585.
22. Fraternali F, Cavallo L, Musco G, Effects of pathological mutations on the stability of a conserved amino acid triad in retinoschisin. FEBS Lett. 2003;544:21-26.
23. Macdonald JL, Pike LJ. A simplified method for the preparation of detergent-free lipid rafts. J Lipid Res. 2005;46:1061-1067.
24. Zhao WQ, Waisman DM, Grimaldi M. Specific localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning. J Neurochem. 2004;90:609-620.
25. Li L, Shin OH, Rhee JS, et al. Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. J Biol Chem. 2006;281:15845-15852.
26. Valencia A, Pestana A, Cano A, Spectroscopical studies on the structural organization of the lectin discoidin I: analysis of sugarand calcium-binding activities. Biochim Biophys Acta. 1989;990:93-97.
27. Wu WW, Molday RS. Defective discoidin domain structure, subunit assembly, and endoplasmic reticulum processing of retinoschisin are primary mechanisms responsible for X-linked retinoschisis. J Biol Chem. 2003;278:28139- 28146.
28. Claudepierre T, Manglapus MK, Marengi N, et al. Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system. J Comp Neurol. 2005;487:190-203.
29. Ihanamaki T, Pelliniemi LJ, Vuorio E. Collagens and collagen-related matrix components in the human and mouse eye. Prog Retin Eye Res. 2004;23:403-434.
30. Steiner-Champliaud MF, Sahel J, Hicks D. Retinoschisin forms a multi-molecular complex with extracellular matrix and cytoplasmic proteins: interactions with beta2 laminin and alphaB-crystallin. Mol Vis. 2006;12:892-901.
31. Geiger B, Bershadsky A, Pankov R, Yamada KM. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev Mol Cell Biol. 2001;2:793-805.
32. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell. 1996;84:345-357.