Type i IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity

Innate Immunity

Volumn 21, Issue 6, 2015, Pages 626-634

  Karimi, Khalil ^a   Karimi, Yalda ^b   Chan, Jeffrey ^b   Boudreau, Jeanette E ^b   Basset, Jennifer ^b   Chew, Marianne V ^b   Reid, Sarah ^b   Bramson, Jonathan L ^b   Wan, Yonghong ^b   Ashkar, Ali A ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

DC vaccine; IL 15; IL 15Ra; NK cells; Type I interferon

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON RECEPTOR; DENDRITIC CELL VACCINE; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; CANCER VACCINE; INTERFERON-ALPHA 8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER IMMUNIZATION; CELL ACTIVATION; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LOSS; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; IN VIVO STUDY; INNATE IMMUNITY; INTRAPLANTAR DRUG ADMINISTRATION; MELANOMA; MELANOMA CELL LINE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; 129 MOUSE; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; METASTASIS; PHYSIOLOGY; SKIN NEOPLASMS; TRANSPLANTATION;

MURINAE; MUS;

ANIMALS; CANCER VACCINES; CELL COMMUNICATION; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; INTERFERON-ALPHA; INTERLEUKIN-15; KILLER CELLS, NATURAL; MELANOMA; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM METASTASIS; RECEPTORS, INTERLEUKIN-15; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 84936138327     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425915575078     Document Type: Article

References (35)

1. Hoglund P, Klein E,. Natural killer cells in cancer. Semin Cancer Biol 2006; 16: 331-332.
2. Walzer T, Blery M, Chaix J,. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A 2007; 104: 3384-3389.
3. Boyiadzis M, Foon KA, Herberman RB,. NK cells in cancer immunotherapy: three decades of discovery. Discov Med 2006; 6: 243-248.
4. Suck G,. Novel approaches using natural killer cells in cancer therapy. Semin Cancer Biol 2006; 16: 412-418.
5. Trapani JA, Smyth MJ,. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2002; 2: 735-747.
6. Pestka S, Krause CD, Walter MR,. Interferons, interferon-like cytokines, and their receptors. Immunol Rev 2004; 202: 8-32.
7. Fernandez NC, Lozier A, Flament C,. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999; 5: 405-411.
8. Boudreau JE, Bridle BW, Stephenson KB,. Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity. Mol Ther 2009; 17: 1465-1472.
9. Boudreau JE, Stephenson KB, Wang F,. IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer Res 2011; 71: 2497-2506.
10. Bouwer AL, Saunderson SC, Caldwell FJ,. NK cells are required for dendritic cell-based immunotherapy at the time of tumor challenge. J Immunol 2014; 192: 2514-2521.
11. Karimi K, Boudreau JE, Fraser K,. Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells. Mol Ther 2008; 16: 411-418.
12. van den Broeke LT, Daschbach E, Thomas EK,. Dendritic cell-induced activation of adaptive and innate antitumor immunity. J Immunol 2003; 171: 5842-5852.
13. Kim A, Noh YW, Kim KD,. Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination. Exp Mol Med 2004; 36: 428-443.
14. de Jong JL, Farner NL, Widmer MB,. Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex. J Immunol 1996; 156: 1339-1348.
15. Bergamaschi C, Rosati M, Jalah R,. Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. J Biol Chem 2008; 283: 4189-4199.
16. Mortier E, Woo T, Advincula R,. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 2008; 205: 1213-1225.
17. Lucas M, Schachterle W, Oberle K,. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 2007; 26: 503-517.
18. Martinez J, Huang X, Yang Y,. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. J Immunol 2008; 180: 1592-1597.
19. Lutz MB, Kukutsch N, Ogilvie AL,. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999; 223: 77-92.
20. Jung S, Unutmaz D, Wong P,. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 2002; 17: 211-220.
21. Gilboa E,. DC-based cancer vaccines. J Clin Invest 2007; 117: 1195-1203.
22. Galluzzi L, Senovilla L, Vacchelli E,. Trial watch: Dendritic cell-based interventions for cancer therapy. Oncoimmunology 2012; 1: 1111-1134.
23. Wu J, Lanier LL,. Natural killer cells and cancer. Adv Cancer Res 2003; 90: 127-156.
24. Borg C, Jalil A, Laderach D,. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood 2004; 104: 3267-3275.
25. Ferlazzo G, Pack M, Thomas D,. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci U S A 2004; 101: 16606-16611.
26. Granucci F, Zanoni I, Pavelka N,. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med 2004; 200: 287-295.
27. Gerosa F, Baldani-Guerra B, Nisii C,. Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 2002; 195: 327-333.
28. Ferlazzo G, Tsang ML, Moretta L,. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med 2002; 195: 343-351.
29. Yu Y, Hagihara M, Ando K,. Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. J Immunol 2001; 166: 1590-1600.
30. Nishioka Y, Nishimura N, Suzuki Y, Sone S,. Human monocyte-derived and CD83(+) blood dendritic cells enhance NK cell-mediated cytotoxicity. Eur J Immunol 2001; 31: 2633-2641.
31. Fernandez NC, Flament C, Crepineau F,. Dendritic cells (DC) promote natural killer (NK) cell functions: dynamics of the human DC/NK cell cross talk. Eur Cytokine Netw 2002; 13: 17-27.
32. Koka R, Burkett P, Chien M,. Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells. J Immunol 2004; 173: 3594-3598.
33. Jinushi M, Takehara T, Kanto T,. Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection. J Immunol 2003; 170: 1249-1256.
34. Andoniou CE, van Dommelen SL, Voigt V,. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol 2005; 6: 1011-1019.
35. Gill N, Deacon PM, Lichty B,. Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production. J Virol 2006; 80: 9943-9950.