Kidney damage biomarkers detect acute kidney injury but only functional markers predict mortality after paraquat ingestion

Toxicology Letters

Volumn 237, Issue 2, 2015, Pages 140-150

  Mohamed, Fahim ^a,b,c,d   Buckley, Nicholas A ^a,b,d   Jayamanne, Shaluka ^a   Pickering, John W ^e,f   Peake, Philip ^c   Palangasinghe, Chathura ^a   Wijerathna, Thilini ^a   Ratnayake, Indira ^a   Shihana, Fathima ^a   Endre, Zoltan H ^c,e  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d University of Sydney   (Australia)

^e UNIVERSITY OF OTAGO   (New Zealand)

^f CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

Acute kidney injury; Biomarker thresholds; Paraquat poisoning; Structural biomarkers; Urinary clusterin

Indexed keywords

ALBUMIN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CLUSTERIN; CREATININE; CYSTATIN C; GROWTH FACTOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; PARAQUAT; TREFOIL FACTOR 3; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; CLU PROTEIN, HUMAN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; AUTOANALYZER; BLOOD SAMPLING; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CREATININE URINE LEVEL; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; ELISA KIT; ENZYME BLOOD LEVEL; FATALITY; FEMALE; FOLLOW UP; HUMAN; INGESTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY (TOPIC); NEPHROTOXICITY; OUTCOME ASSESSMENT; PARAQUAT POISONING; PRIORITY JOURNAL; SELF POISONING; SENSITIVITY AND SPECIFICITY; URINALYSIS; ACUTE KIDNEY INJURY; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; KIDNEY; URINE;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; ADULT; BIOLOGICAL MARKERS; CLUSTERIN; CREATININE; CYSTATIN C; FEMALE; HUMANS; KIDNEY; LIPOCALINS; MALE; PARAQUAT; PROTO-ONCOGENE PROTEINS;

EID: 84936101469     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.06.008     Document Type: Article

References (50)

1. Alpert J.S., Thygesen K., Antman E., Bassand J.P. Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J. Am. Coll. Cardiol. 2000, 36:959-969.
2. Bagshaw S.M., Bellomo R. Cystatin C in acute kidney injury. Curr. Opin. Crit. Care 2010.
3. Basu R.K., Wong H.R., Krawczeski C.D., Wheeler D.S., Manning P.B., Chawla L.S., Devarajan P., Goldstein S.L. Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery. J. Am. Coll. Cardiol. 2014, 64:2753-2762.
4. Beebeejaun A.R., Beevers G., Rogers W.N. Paraquat poisoning-prolonged excretion. Clin. Toxicol. 1971, 4:397-407.
5. Bellomo R., Ronco C., Kellum J.A., Mehta R.L., Palevsky P. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 2004, 8:R204-R212.
6. Bolignano D., Donato V., Coppolino G., Campo S., Buemi A., Lacquaniti A., Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am. J. Kidney Dis. 2008, 52:595-605.
7. Bonventre J.V., Vaidya V.S., Schmouder R., Feig P., Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat. Biotechnol. 2010, 28:436-440.
8. Briguori C., Visconti G., Rivera N.V., Focaccio A., Golia B., Giannone R., Castaldo D., De Micco F., Ricciardelli B., Colombo A. Cystatin C and contrast-induced acute kidney injury. Circulation 2010, 121:2117-2122.
9. Cai L., Rubin J., Han W., Venge P., Xu S. The origin of multiple molecular forms in urine of HNL/NGAL. Clin. J. Am. Soc. Nephrol. 2010, 5:2229-2235.
10. Chertow G.M., Burdick E., Honour M., Bonventre J.V., Bates D.W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 2005, 16:3365-3370.
11. Dawson A.H., Eddleston M., Senarathna L., Mohamed F., Gawarammana I., Bowe S.J., Manuweera G., Buckley N.A. Acute human lethal toxicity of agricultural pesticides: a prospective cohort study. PLoS Med. 2010, 7:e1000357.
12. Dieterle F., Sistare F., Goodsaid F., Papaluca M., Ozer J.S., Webb C.P., Baer W., Senagore A., Schipper M.J., Vonderscher J., Sultana S., Gerhold D.L., Phillips J.A., Maurer G., Carl K., Laurie D., Harpur E., Sonee M., Ennulat D., Holder D., Andrews-Cleavenger D., Gu Y.Z., Thompson K.L., Goering P.L., Vidal J.M., Abadie E., Maciulaitis R., Jacobson-Kram D., Defelice A.F., Hausner E.A., Blank M., Thompson A., Harlow P., Throckmorton D., Xiao S., Xu N., Taylor W., Vamvakas S., Flamion B., Lima B.S., Kasper P., Pasanen M., Prasad K., Troth S., Bounous D., Robinson-Gravatt D., Betton G., Davis M.A., Akunda J., McDuffie J.E., Suter L., Obert L., Guffroy M., Pinches M., Jayadev S., Blomme E.A., Beushausen S.A., Barlow V.G., Collins N., Waring J., Honor D., Snook S., Lee J., Rossi P., Walker E., Mattes W. Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium. Nat. Biotechnol. 2010, 28:455-462.
13. Dinis-Oliveira R.J., Duarte J.A., Sanchez-Navarro A., Remiao F., Bastos M.L., Carvalho F. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit. Rev. Toxicol. 2008, 38:13-71.
14. Eddleston M., Wilks M.F., Buckley N.A. Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review. QJM 2003, 96:809-824.
15. Endre Z.H., Walker R.J., Pickering J.W., Shaw G.M., Frampton C.M., Henderson S.J., Hutchison R., Mehrtens J.E., Robinson J.M., Schollum J.B., Westhuyzen J., Celi L.A., McGinley R.J., Campbell I.J., George P.M. Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int. 2010, 77:1020-1030.
16. Ferguson M.A., Vaidya V.S., Bonventre J.V. Biomarkers of nephrotoxic acute kidney injury. Toxicology 2008, 245:182-193.
17. Gaiao S., Cruz D.N. Baseline creatinine to define acute kidney injury: is there any consensus?. Nephrol. Dial. Transplant. 2010, 25:3812-3814.
18. Gawarammana I.B., Buckley N.A. Medical management of paraquat ingestion. Br. J. Clin. Pharmacol. 2011, 72:745-757.
19. Gil H.W., Yang J.O., Lee E.Y., Hong S.Y. Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxication. Clin. Toxicol. (Phila.) 2009, 47:870-875.
20. Haase M., Devarajan P., Haase-Fielitz A., Bellomo R., Cruz D.N., Wagener G., Krawczeski C.D., Koyner J.L., Murray P., Zappitelli M., Goldstein S.L., Makris K., Ronco C., Martensson J., Martling C.R., Venge P., Siew E., Ware L.B., Ikizler T.A., Mertens P.R. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J. Am. Coll. Cardiol. 2011, 57:1752-1761.
21. Hoste E.A., Clermont G., Kersten A., Venkataraman R., Angus D.C., De Bacquer D., Kellum J.A. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit. Care 2006, 10:R73.
22. Inker L.A., Schmid C.H., Tighiouart H., Eckfeldt J.H., Feldman H.I., Greene T., Kusek J.W., Manzi J., Van Lente F., Zhang Y.L., Coresh J., Levey A.S. Estimating glomerular filtration rate from serum creatinine and cystatin C. N. Engl. J. Med. 2012, 367:20-29.
23. KDIGO Kidney disease: improving global outcomes (KDIGO). Acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. Suppl. 2012, 2:19-26.
24. Kim S.J., Gil H.W., Yang J.O., Lee E.Y., Hong S.Y. The clinical features of acute kidney injury in patients with acute paraquat intoxication. Nephrol. Dial. Transplant. 2009, 24:1226-1232.
25. Koo J.R., Kim J.C., Yoon J.W., Kim G.H., Jeon R.W., Kim H.J., Chae D.W., Noh J.W. Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning. Am. J. Kidney. Dis. 2002, 39:55-59.
26. Lee E.Y., Hwang K.Y., Yang J.O., Hong S.Y. Predictors of survival after acute paraquat poisoning. Toxicol. Ind. Health 2002, 18:201-206.
27. Lopes J.A., Fernandes P., Jorge S., Goncalves S., Alvarez A., Costa e Silva Z., Franca C., Prata M.M. Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the acute kidney injury network classifications. Crit. Care 2008, 12:R110.
28. Mehta R.L., Kellum J.A., Shah S.V., Molitoris B.A., Ronco C., Warnock D.G., Levin A. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit. Care 2007.
29. Mohamed F., Endre Z., Jayamanne S., Pianta T.J., Peake P., Palangasinghe C., Chathuranga U., Jayasekara K., Wunnapuk K., Shihana F., Shahmy S., Buckley N. Mechanisms underlying early rapid increases in creatinine in paraquat poisoning. PLoS One 2015, 10(3):e0122357. (eCollection). 10.1371/journal.pone.0122357.
30. Mori K., Lee H.T., Rapoport D., Drexler I.R., Foster K., Yang J., Schmidt-Ott K.M., Chen X., Li J.Y., Weiss S., Mishra J., Cheema F.H., Markowitz G., Suganami T., Sawai K., Mukoyama M., Kunis C., D'Agati V., Devarajan P., Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Invest. 2005, 115:610-621.
31. Morrow D.A., Cannon C.P., Jesse R.L., Newby L.K., Ravkilde J., Storrow A.B., Wu A.H., Christenson R.H., Apple F.S., Francis G., Tang W. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Clin. Chem. 2007, 53:552-574.
32. Murray P.T., Mehta R.L., Shaw A., Ronco C., Endre Z., Kellum J.A., Chawla L.S., Cruz D., Ince C., Okusa M.D. Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int. 2014, 85:513-521.
33. Nath K.A., Dvergsten J., Correa-Rotter R., Hostetter T.H., Manivel J.C., Rosenberg M.E. Induction of clusterin in acute and chronic oxidative renal disease in the rat and its dissociation from cell injury. Lab. Invest. 1994, 71:209-218.
34. Nejat M., Pickering J.W., Walker R.J., Endre Z.H. Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrol. Dial. Transplant. 2010, 25:3283-3289.
35. Nickolas T.L., Schmidt-Ott K.M., Canetta P., Forster C., Singer E., Sise M., Elger A., Maarouf O., Sola-Del Valle D.A., O'Rourke M., Sherman E., Lee P., Geara A., Imus P., Guddati A., Polland A., Rahman W., Elitok S., Malik N., Giglio J., El-Sayegh S., Devarajan P., Hebbar S., Saggi S.J., Hahn B., Kettritz R., Luft F.C., Barasch J. Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J. Am. Coll. Cardiol. 2012, 59:246-255.
36. Pickering J.W., Endre Z.H. The clinical utility of plasma neutrophil gelatinase-associated lipocalin in acute kidney injury. Blood Purif. 2013, 35:295-302.
37. Pickering J.W., Endre Z.H. Linking injury to outcome in acute kidney injury: a matter of sensitivity. PLoS One 2013, 8:e62691.
38. Pickering J.W., Endre Z.H. The definition and detection of acute kidney injury. J. Renal Inj. Prev. 2014, 3:21-25.
39. Ralib A.M., Pickering J.W., Shaw G.M., Devarajan P., Edelstein C.L., Bonventre J.V., Endre Z.H. Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J. Am. Soc. Nephrol. 2012, 23:322-333.
40. Roberts D.M., Wilks M.F., Roberts M.S., Swaminathan R., Mohamed F., Dawson A.H., Buckley N.A. Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning. Toxicol. Lett. 2011, 202:69-74.
41. Rosenberg M.E., Silkensen J. Clusterin: physiologic and pathophysiologic considerations. Int. J. Biochem. Cell Biol. 1995, 27:633-645.
42. Schwochau G.B., Nath K.A., Rosenberg M.E. Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties. Kidney Int. 1998, 53:1647-1653.
43. Siew E.D., Ware L.B., Ikizler T.A. Biological markers of acute kidney injury. J. Am. Soc. Nephrol. 2011, 22:810-820.
44. Silkensen J.R., Agarwal A., Nath K.A., Manivel J.C., Rosenberg M.E. Temporal induction of clusterin in cisplatin nephrotoxicity. J. Am. Soc. Nephrol. 1997, 8:302-305.
45. Suzuki K., Takasu N., Okabe T., Ishimatsu S., Ueda A., Tanaka S., Fukuda A., Arita S., Kohama A. Effect of aggressive haemoperfusion on the clinical course of patients with paraquat poisoning. Hum. Exp. Toxicol. 1993, 12:323-327.
46. Waikar S.S., Betensky R.A., Emerson S.C., Bonventre J.V. Imperfect gold standards for kidney injury biomarker evaluation. J. Am. Soc. Nephrol. 2012, 23:13-21.
47. Weng C.H., Hu C.C., Lin J.L., Lin-Tan D.T., Huang W.H., Hsu C.W., Yen T.H. Sequential organ failure assessment score can predict mortality in patients with paraquat intoxication. PLoS One 2012, 7:e51743.
48. Westhuyzen J., Endre Z.H., Reece G., Reith D.M., Saltissi D., Morgan T.J. Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit. Nephrol. Dial. Transplant. 2003, 18:543-551.
49. Wunnapuk K., Liu X., Peake P., Gobe G., Endre Z., Grice J.E., Roberts M.S., Buckley N.A. Renal biomarkers predict nephrotoxicity after paraquat. Toxicol. Lett. 2013, 222:280-288.
50. Wunnapuk K., Medley G.A., Liu X., Grice J.E., Jayasinghe S., Gawarammana I., Buckley N.A., Roberts M.S. Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: application to experimental and clinical toxicological studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2011, 879:3047-3052.