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Volumn 58, Issue 11, 2015, Pages 4703-4712

Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents

Author keywords

[No Author keywords available]

Indexed keywords

18 [2 [(2,2 DI FLUOROETHYL)AMINO]ETHYL] 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 24 (DIMETHYLAMINO) 4,5,8,25 TETRAHYDROXY 17,21 DIOXO 2 (TRIFLUOROMETHOXY) 5,13 DIAZAHEPTACYCLO[14.12.0.0 3,14 .0 4,11 .0 5,9 .0 18,27 .0 20,25 ]OCTACOSA 1,3(14),15,18,22 PENTAENE 22 CARBOXAMIDE; 25 (DIMETHYLAMINO) 16,20,21,24 TETRAHYDROXY 18,22 DIOXO 2 (TRIFLUOROMETHOXY) 5,14 DIAZAHEPTACYCLO[15.12.0.0 3,15 .0 4,12 .0 5,10 .0 19,28 .0 21,26 ]NONACOSA 1,3(15),16,19,23 PENTAENE 23 CARBOXAMIDE; 25 (DIMETHYLAMINO) 16,20,21,24 TETRAHYDROXY 18,22 DIOXO 2 (TRIFLUOROMETHOXY) 8 OXA 5,14 DIAZAHEPTACYCLO[15.12.0.0 3,15 .0 4,12 .0 5,10 .0 19,28 .0 21,26 ]NONACOSA 1,3(15),16,19,23 PENTAENE 23 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 18 (2 HYDROXYETHYL) 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 18 METHYL 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 18 [2 (N METHYLACETAMIDO)ETHYL] 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 18,21 DIMETHYL 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 21 METHYL 2,6 DIOXO 18 PROPYL 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 15 FLUORO 4,5,8,25 TETRAHYDROXY 21 METHYL 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 18 ETHYL 15 FLUORO 4,5,8,25 TETRAHYDROXY 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 18 [2 (DIMETHYLAMINO)ETHYL] 15 FLUORO 4,5,8,25 TETRAHYDROXY 2,6 DIOXO 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 4,5,8,25 TETRAHYDROXY 18 METHYL 2,6 DIOXO 15 (TRIFLUOROMETHOXY) 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 4,5,8,25 TETRAHYDROXY 18,19 DIMETHYL 2,6 DIOXO 15 (TRIFLUOROMETHOXY) 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; 9 (DIMETHYLAMINO) 4,5,8,25 TETRAHYDROXYL 2,6 DIOXO 15 (TRIFLUOROMETHOXY) 18,23 DIAZAHEXACYCLO[12.11.0.0 3,12 .0 5,10 .0 16,24 .0 17,21 ]PENTACOSA 1(25),3,7,14,16(24) PENTAENE 7 CARBOXAMIDE; AMIKACIN; LEVOFLOXACIN; MEROPENEM; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

EID: 84935894371     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00262     Document Type: Article
Times cited : (16)

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