Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 8112-8138

  Clark, Roger B ^a   He, Minsheng ^a   Deng, Yonghong ^a   Sun, Cuixiang ^a   Chen, Chi Li ^a   Hunt, Diana K ^a   O'Brien, William J ^a   Fyfe, Corey ^a   Grossman, Trudy H ^a   Sutcliffe, Joyce A ^a   Achorn, Catherine ^a   Hogan, Philip C ^a   Katz, Christopher E ^a   Niu, John ^a   Zhang, Wu Yan ^a   Zhu, Zhijian ^a   Ronn, Magnus ^a   Xiao, Xiao Yi ^a  

^a Tetraphase Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 AMINOMETHYLTETRACYCLINE DERIVATIVE; CILASTATIN; LEVOFLOXACIN; MEROPENEM; OMADACYCLINE; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PNEUMONIA; PYELONEPHRITIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PNEUMONIA; PYELONEPHRITIS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINE RESISTANCE; TETRACYCLINES; TREATMENT OUTCOME;

EID: 84886568587     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401211t     Document Type: Article

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