Environmental isolates of azole-resistant Aspergillus fumigatus in Germany

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 7, 2015, Pages 4356-4359

  Bader, Oliver ^a   Tünnermann, Jana ^a   Dudakova, Anna ^a   Tangwattanachuleeporn, Marut ^a,b   Weig, Michael ^a   Groß, Uwe ^a   Hoberg, Nora ^c   Geibel, Stephan ^c   Vogel, Eva ^c   Büntzel, Judith ^c   Springer, Jan ^c   Lehning, Luca Yves ^c   Schadel Chr ^c   Antweiler, Elisabeth ^c   Metzger, Luise ^c   Zautner, Andreas ^c   Buchheidt, Dieter ^c   Spiess, Birgit ^c   Hamprecht, Axel ^c   Steinmann, Jörg ^c   Rößler, Susann ^c   Wiegmann, Sara ^c   Klingebiel, Sara ^c   Loock, Ann Chr ^c   Hegewald, Jana ^c   Hassenpflug, Maike ^c   Aurin, Angela ^c   Szymczak, Julian ^c   Diffloth, Nathalie ^c   Kuhns, Martin ^c   more..

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b BURAPHA UNIVERSITY   (Thailand)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ITRACONAZOLE; POSACONAZOLE; PYRROLE; VORICONAZOLE; ANTIFUNGAL AGENT; PYRROLE DERIVATIVE;

ALLELE; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLUS FUMIGATUS; BROTH DILUTION; FUNGAL STRAIN; FUNGUS ISOLATION; GENOTYPE; GERMANY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SOIL; ASPERGILLOSIS; DRUG EFFECTS; FUNGUS SPORE; GENETICS; GEOGRAPHY; HUMAN; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY;

ALLELES; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; AZOLES; DRUG RESISTANCE, FUNGAL; GENOTYPE; GEOGRAPHY; GERMANY; HUMANS; MICROBIAL SENSITIVITY TESTS; SOIL MICROBIOLOGY; SPORES, FUNGAL;

EID: 84935883064     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00100-15     Document Type: Article

References (24)

1. Snelders E, van der Lee HA, Kuijpers J, Rijs AJ, Varga J, Samson RA, Mellado E, Donders AR, Melchers WJ, Verweij PE. 2008. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med 5:e219. http://dx.doi.org/10.1371/journal.pmed.0050219.
2. Howard SJ, Cerar D, Anderson MJ, Albarrag A, Fisher MC, Pasqualotto AC, Laverdiere M, Arendrup MC, Perlin DS, Denning DW. 2009. Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 15:1068-1076. http://dx.doi.org/10.3201/eid1507.090043.
3. Camps SM, van der Linden JW, Li Y, Kuijper EJ, van Dissel JT, Verweij PE, Melchers WJ. 2012. Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature. Antimicrob Agents Chemother 56:10-16. http://dx.doi.org/10.1128/AAC.05088-11.
4. Snelders E, Camps SM, Karawajczyk A, Schaftenaar G, Kema GH, van der Lee HA, Klaassen CH, Melchers WJ, Verweij PE. 2012. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. PLoS One 7:e31801. http://dx.doi.org/10.1371/journal.pone.0031801.
5. Vermeulen E, Maertens J, Schoemans H, Lagrou K. 2012. Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012. Euro Surveill 17:pii=20326. http://www .eurosurveillance.org/ViewArticle.aspx?ArticleId=20326.
6. Rath PM, Buchheidt D, Spiess B, Arfanis E, Buer J, Steinmann J. 2012. First reported case of azole-resistant Aspergillus fumigatus due to the TR/L98H mutation in Germany. Antimicrob Agents Chemother 56:6060-6061. http://dx.doi.org/10.1128/AAC.01017-12.
7. Hamprecht A, Buchheidt D, Vehreschild JJ, Cornely OA, Spiess B, Plum G, Halbsguth TV, Kutsch N, Stippel D, Kahl P, Persigehl T, Steinbach A, Bos B, Hallek M, Vehreschild MJ. 2012. Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany. Euro Surveill 17:pii=20262. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20262.
8. Bader O, Weig M, Reichard U, Lugert R, Kuhns M, Christner M, Held J, Peter S, Schumacher U, Buchheidt D, Tintelnot K, Gross U. 2013. cyp51A-based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany. Antimicrob Agents Chemother 57:3513-3517. http://dx.doi.org/10.1128/AAC.00167-13.
9. Fischer J, van Koningsbruggen-Rietschel S, Rietschel E, Vehreschild MJ, Wisplinghoff H, Kronke M, Hamprecht A. 2014. Prevalence and molecular characterization of azole resistance in Aspergillus spp. isolates from German cystic fibrosis patients. J Antimicrob Chemother 69:1533-1536. http://dx.doi.org/10.1093/jac/dku009.
10. Chowdhary A, Sharma C, van den Boom M, Yntema JB, Hagen F, Verweij PE, Meis JF. 2014. Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania. J Antimicrob Chemother 69:2979-2983. http://dx.doi.org/10.1093/jac/dku259.
11. Pham CD, Reiss E, Hagen F, Meis JF, Lockhart SR. 2014. Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013. Emerg Infect Dis 20:1498-1503. http://dx.doi.org/10.3201/eid2009.140142.
12. Subcommittee on Antifungal Susceptibility Testing of the ESCMID European Committee for Antimicrobial Susceptibility Testing. 2008. EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds. Clin Microbiol Infect 14:982-984. http://dx.doi.org/10.1111/j.1469-0691.2008.02086.x.
13. Steinmann J, Hamprecht A, Vehreschild MJ, Cornely OA, Buchheidt D, Spiess B, Koldehoff M, Buer J, Meis JF, Rath PM. 27 January 2015, posting date. Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany. J Antimicrob Chemother http://dx.doi.org/10.1093/jac/dku566.
14. Klaassen CH, de Valk HA, Balajee SA, Meis JF. 2009. Utility of CSP typing to sub-type clinical Aspergillus fumigatus isolates and proposal for a new CSP type nomenclature. J Microbiol Methods 77:292-296. http://dx.doi.org/10.1016/j.mimet.2009.03.004.
15. Gao LJ, Sun Y, Wan Z, Li RY, Yu J. 2013. CSP typing of Chinese Aspergillus fumigatus isolates: identification of additional CSP types. Med Mycol 51:683-687. http://dx.doi.org/10.3109/13693786.2013.770609.
16. Balajee SA, Tay ST, Lasker BA, Hurst SF, Rooney AP. 2007. Characterization of a novel gene for strain typing reveals substructuring of Aspergillus fumigatus across North America. Eukaryot Cell 6:1392-1399. http://dx.doi.org/10.1128/EC.00164-07.
17. Kidd SE, Nik Zulkepeli NA, Slavin MA, Morrissey CO. 2009. Utility of a proposed CSP typing nomenclature for Australian Aspergillus fumigatus isolates: identification of additional CSP types and suggested modifications. J Microbiol Methods 78:223-226. http://dx.doi.org/10.1016/j.mimet.2009.06.003.
18. van der Linden JW, Camps SM, Kampinga GA, Arends JP, Debets- Ossenkopp YJ, Haas PJ, Rijnders BJ, Kuijper EJ, van Tiel FH, Varga J, Karawajczyk A, Zoll J, Melchers WJ, Verweij PE. 2013. Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles. Clin Infect Dis 57:513-520. http://dx.doi.org/10.1093/cid/cit320.
19. Astvad KM, Jensen RH, Hassan TM, Mathiasen EG, Thomsen GM, Pedersen UG, Christensen M, Hilberg O, Arendrup MC. 2014. First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment. Antimicrob Agents Chemother 58:5096-5101. http://dx.doi.org/10.1128/AAC.02855-14.
20. Arendrup MC, Mavridou E, Mortensen KL, Snelders E, Frimodt-Moller N, Khan H, Melchers WJ, Verweij PE. 2010. Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence. PLoS One 5:e10080. http://dx.doi.org/10.1371/journal.pone.0010080.
21. Bromley MJ, van Muijlwijk G, Fraczek MG, Robson G, Verweij PE, Denning DW, Bowyer P. 2014. Occurrence of azole-resistant species of Aspergillus in the UK environment. J Glob Antimicrob Resist 2:276-279. http://dx.doi.org/10.1016/j.jgar.2014.05.004.
22. Mortensen KL, Mellado E, Lass-Florl C, Rodriguez-Tudela JL, Johansen HK, Arendrup MC. 2010. Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain. Antimicrob Agents Chemother 54:4545-4549. http://dx.doi.org/10.1128/AAC.00692-10.
23. Prigitano A, Venier V, Cogliati M, De Lorenzis G, Esposto MC, Tortorano AM. 2014. Azole-resistant Aspergillus fumigatus in the environment of northern Italy, May 2011 to June 2012. Euro Surveill 19: pii=20747. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20747.
24. Camps SM, Rijs AJ, Klaassen CH, Meis JF, O'Gorman CM, Dyer PS, Melchers WJ, Verweij PE. 2012. Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism. J Clin Microbiol 50:2674-2680. http://dx.doi.org/10.1128/JCM.00335-12.