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Volumn 57, Issue 8, 2013, Pages 3513-3517

Cyp51A-based mechanisms of aspergillus fumigatus azole drug resistance present in clinical samples from Germany

Author keywords

[No Author keywords available]

Indexed keywords

ITRACONAZOLE; POSACONAZOLE; PYRROLE DERIVATIVE; VORICONAZOLE;

EID: 84880261725     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00167-13     Document Type: Article
Times cited : (115)

References (25)
  • 3
    • 79953306496 scopus 로고    scopus 로고
    • Azole resistance in Aspergillus fumigatus: A new challenge in the management of invasive aspergillosis?
    • Snelders E, Melchers WJ, Verweij PE. 2011. Azole resistance in Aspergillus fumigatus: a new challenge in the management of invasive aspergillosis? Future Microbiol. 6:335-347.
    • (2011) Future Microbiol. , vol.6 , pp. 335-347
    • Snelders, E.1    Melchers, W.J.2    Verweij, P.E.3
  • 4
    • 77957342347 scopus 로고    scopus 로고
    • Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B
    • Warrilow AG, Melo N, Martel CM, Parker JE, Nes WD, Kelly SL, Kelly DE. 2010. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob. Agents Chemother. 54:4225-4234.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 4225-4234
    • Warrilow, A.G.1    Melo, N.2    Martel, C.M.3    Parker, J.E.4    Nes, W.D.5    Kelly, S.L.6    Kelly, D.E.7
  • 5
    • 77952597776 scopus 로고    scopus 로고
    • Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling
    • Snelders E, Karawajczyk A, Schaftenaar G, Verweij PE, Melchers WJ. 2010. Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling. Antimicrob. Agents Chemother. 54:2425-2430.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2425-2430
    • Snelders, E.1    Karawajczyk, A.2    Schaftenaar, G.3    Verweij, P.E.4    Melchers, W.J.5
  • 7
    • 71549143158 scopus 로고    scopus 로고
    • Azole resistance in Aspergillus fumigatus: A side-effect of environmental fungicide use?
    • Verweij PE, Snelders E, Kema GH, Mellado E, Melchers WJ. 2009. Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use? Lancet Infect. Dis. 9:789-795.
    • (2009) Lancet Infect. Dis. , vol.9 , pp. 789-795
    • Verweij, P.E.1    Snelders, E.2    Kema, G.H.3    Mellado, E.4    Melchers, W.J.5
  • 8
    • 84871677613 scopus 로고    scopus 로고
    • Clonal expansion and emergence of environmental multiple-triazole- resistant Aspergillus fumigatus strains carrying the TR(34)/L98H mutations in the cyp51A gene in India
    • doi:10.1371/journal.pone.0052871
    • Chowdhary A, Kathuria S, Xu J, Sharma C, Sundar G, Singh PK, Gaur SN, Hagen F, Klaassen CH, Meis JF. 2012. Clonal expansion and emergence of environmental multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR(34)/L98H mutations in the cyp51A gene in India. PLoS One 7:e52871. doi:10.1371/journal.pone.0052871.
    • (2012) PLoS One , vol.7
    • Chowdhary, A.1    Kathuria, S.2    Xu, J.3    Sharma, C.4    Sundar, G.5    Singh, P.K.6    Gaur, S.N.7    Hagen, F.8    Klaassen, C.H.9    Meis, J.F.10
  • 10
    • 52249111185 scopus 로고    scopus 로고
    • EUCAST technical note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds
    • Subcommittee on Antifungal Susceptibility Testing of the ESCMID European Committee for Antimicrobial Susceptibility Testing.
    • Subcommittee on Antifungal Susceptibility Testing of the ESCMID European Committee for Antimicrobial Susceptibility Testing. 2008. EUCAST technical note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds. Clin. Microbiol. Infect. 14:982-984.
    • (2008) Clin. Microbiol. Infect. , vol.14 , pp. 982-984
  • 11
    • 84880263067 scopus 로고    scopus 로고
    • posting date. Antifungal agents-breakpoints table for interpretation of MICs.
    • EUCAST. 2013, posting date. Antifungal agents-breakpoints table for interpretation of MICs. http://www.eucast.org/fileadmin/src/media/PDF s/EUCAST-files/Breakpoint-tables/Antifungal-breakpoints-v-5.0.pdf.
    • (2013)
  • 12
    • 79957438194 scopus 로고    scopus 로고
    • Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: A laboratory-based study with focus on Aspergillus fumigatus azole resistance
    • Mortensen KL, Jensen RH, Johansen HK, Skov M, Pressler T, Howard SJ, Leatherbarrow H, Mellado E, Arendrup MC. 2011. Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance. J. Clin. Microbiol. 49:2243-2251.
    • (2011) J. Clin. Microbiol. , vol.49 , pp. 2243-2251
    • Mortensen, K.L.1    Jensen, R.H.2    Johansen, H.K.3    Skov, M.4    Pressler, T.5    Howard, S.J.6    Leatherbarrow, H.7    Mellado, E.8    Arendrup, M.C.9
  • 13
    • 79952646882 scopus 로고    scopus 로고
    • Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae
    • Alcazar-Fuoli L, Mellado E, Cuenca-Estrella M, Sanglard D. 2011. Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae. Med. Mycol. 49: 276-284.
    • (2011) Med. Mycol. , vol.49 , pp. 276-284
    • Alcazar-Fuoli, L.1    Mellado, E.2    Cuenca-Estrella, M.3    Sanglard, D.4
  • 14
    • 84855860621 scopus 로고    scopus 로고
    • Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India
    • Chowdhary A, Kathuria S, Randhawa HS, Gaur SN, Klaassen CH, Meis JF. 2012. Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India. J. Antimicrob. Chemother. 67:362-366.
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 362-366
    • Chowdhary, A.1    Kathuria, S.2    Randhawa, H.S.3    Gaur, S.N.4    Klaassen, C.H.5    Meis, J.F.6
  • 15
    • 80051827318 scopus 로고    scopus 로고
    • Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene
    • Lockhart SR, Frade JP, Etienne KA, Pfaller MA, Diekema DJ, Balajee SA. 2011. Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene. Antimicrob. Agents Chemother. 55:4465-4468.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 4465-4468
    • Lockhart, S.R.1    Frade, J.P.2    Etienne, K.A.3    Pfaller, M.A.4    Diekema, D.J.5    Balajee, S.A.6
  • 19
    • 77956302523 scopus 로고    scopus 로고
    • Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence
    • doi:10.1371/journal.pone .0010080
    • Arendrup MC, Mavridou E, Mortensen KL, Snelders E, Frimodt-Moller N, Khan H, Melchers WJ, Verweij PE. 2010. Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence. PLoS One 5:e10080. doi:10.1371/journal.pone .0010080.
    • (2010) PLoS One , vol.5
    • Arendrup, M.C.1    Mavridou, E.2    Mortensen, K.L.3    Snelders, E.4    Frimodt-Moller, N.5    Khan, H.6    Melchers, W.J.7    Verweij, P.E.8
  • 20
    • 84870590660 scopus 로고    scopus 로고
    • Discovery of a hapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing
    • doi:10.1371/journal.pone .0050034
    • Camps SM, Dutilh BE, Arendrup MC, Rijs AJ, Snelders E, Huynen MA, Verweij PE, Melchers WJ. 2012. Discovery of a hapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing. PLoS One 7:e50034. doi:10.1371/journal.pone .0050034.
    • (2012) PLoS One , vol.7
    • Camps, S.M.1    Dutilh, B.E.2    Arendrup, M.C.3    Rijs, A.J.4    Snelders, E.5    Huynen, M.A.6    Verweij, P.E.7    Melchers, W.J.8
  • 21
    • 80054697382 scopus 로고    scopus 로고
    • Interrogation of related clinical pan-azoleresistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter
    • Albarrag AM, Anderson MJ, Howard SJ, Robson GD, Warn PA, Sanglard D, Denning DW. 2011. Interrogation of related clinical pan-azoleresistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter. Antimicrob. Agents Chemother. 55:5113-5121.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 5113-5121
    • Albarrag, A.M.1    Anderson, M.J.2    Howard, S.J.3    Robson, G.D.4    Warn, P.A.5    Sanglard, D.6    Denning, D.W.7
  • 22
    • 0036346165 scopus 로고    scopus 로고
    • Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate
    • Slaven JW, Anderson MJ, Sanglard D, Dixon GK, Bille J, Roberts IS, Denning DW. 2002. Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate. Fungal Genet. Biol. 36:199-206.
    • (2002) Fungal Genet. Biol. , vol.36 , pp. 199-206
    • Slaven, J.W.1    Anderson, M.J.2    Sanglard, D.3    Dixon, G.K.4    Bille, J.5    Roberts, I.S.6    Denning, D.W.7
  • 24
    • 84878623072 scopus 로고    scopus 로고
    • Invasive aspergillosis: New insights into disease, diagnostic and treatment
    • Karthaus M, Buchheidt D. 2013. Invasive aspergillosis: new insights into disease, diagnostic and treatment. Curr. Pharm. Des. 19:3569-3594.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 3569-3594
    • Karthaus, M.1    Buchheidt, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.