Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects

Journal of Pharmaceutical and Biomedical Analysis

Volumn 115, Issue , 2015, Pages 48-54

  Zhao, Chungang ^a,i   Du, Huijie ^b   Xu, Li ^c,d   Wang, Jiao ^e,f   Tang, Ling ^e,f   Cao, Yunfeng ^g   Li, Chen ^g   Wang, Qingjun ^g   Liu, Yang ^e   Shan, Fengping ^a   Feng, Juan ^a   Xu, Fang ^b   Gao, Peng ^e,g,h  

^a CHINA MEDICAL UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^e DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^f DALIAN UNIVERSITY   (China)

^g JINZHOU MEDICAL UNIVERSITY   (China)

^h Dalian Sixth People's Hospital   (China)

ⁱ Department of Neurology Dalian (Municipal) Friendship Hospital (Dalian Red Cross Hospital)   (China)

Author keywords

Capillary electrophoresis mass spectrometry; Metabolomics; Methionine enkephalin; Multiple sclerosis

Indexed keywords

CYTOPROTECTIVE AGENT; GLYCYLGLYCINE; METENKEPHALIN; METHIONINE; NITRIC OXIDE; PHENYLALANINE; TYROSINE; CYTOKINE; METHIONINE-ENKEPHALIN RECEPTOR; NEUROPROTECTIVE AGENT; OPIATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CAPILLARY ELECTROPHORESIS; CELL FUNCTION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; MOUSE MODEL; NERVE CELL INHIBITION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REMYELINIZATION; TIME OF FLIGHT MASS SPECTROMETRY; ANIMAL; CLUSTER ANALYSIS; DEVICES; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; NERVE CELL; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ASTROCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; CLUSTER ANALYSIS; CYTOKINES; ELECTROPHORESIS, CAPILLARY; ENKEPHALIN, METHIONINE; GLYCYLGLYCINE; HUMANS; MASS SPECTROMETRY; METABOLOMICS; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; RATS; RECEPTORS, OPIOID;

EID: 84935487473     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.06.028     Document Type: Article

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