Dietary plant sterol esters must be hydrolyzed to reduce intestinal cholesterol absorption in hamsters

Journal of Nutrition

Volumn 145, Issue 7, 2015, Pages 1402-1407

  Carden, Trevor J ^a,b   Hang, Jiliang ^a   Dussault, Patrick H ^a   Carr, Timothy P ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Cholesterol absorption; Hamsters; Intestinal hydrolysis; Micelles; Phytosterol esters; Plant sterol esters

Indexed keywords

BILE ACID; CHOLESTEROL; COCONUT OIL; ESTER DERIVATIVE; ETHER DERIVATIVE; PHYTOSTEROL; STEROL; STEROL OLEATE ESTER; STEROL STEARATE ETHER; SUNFLOWER OIL; UNCLASSIFIED DRUG; CHOLESTEROL INTAKE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; VEGETABLE OIL;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXCRETION; FECES; FOOD INTAKE; HAMSTER; HYDROLYSIS; INTESTINE ABSORPTION; LIPID HYDROLYSIS; LIPID LIVER LEVEL; MALE; NONHUMAN; PLASMA; ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; CHEMISTRY; CHOLESTEROL INTAKE; DIET; LIVER; MESOCRICETUS; METABOLISM; ORGAN SIZE;

CRICETINAE; HELIANTHUS; MESOCRICETUS AURATUS;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, LDL; CRICETINAE; DIET; DIET, ATHEROGENIC; FECES; INTESTINAL ABSORPTION; LIVER; MALE; MESOCRICETUS; ORGAN SIZE; PHYTOSTEROLS; PLANT OILS; STEROLS;

EID: 84935455339     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.207662     Document Type: Article

References (26)

1. Brauner R, Johannes C, Ploessl F, Bracher F, Lorenz RL. Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor alpha activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. J Nutr 2012;142:981-9.
2. Jesch ED, Seo JM, Carr TP, Lee JY. Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells. Nutr Res 2009;29:859-66.
3. Carr TP, Ash MM, Brown AW. Cholesterol-lowering phytosterols: factors affecting their use and efficacy. Nutr Diet Suppl 2010;3:59-72.
4. Armstrong MJ, Carey MC. Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J Lipid Res 1987;28:1144-55.
5. Brown AW, Hang J, Dussault PH, Carr TP. Phytosterol ester constituents affect micellar cholesterol solubility in model bile. Lipids 2010;45:855-62.
6. Elliot D, Jesch TPC. Sitosterol reduces micellar cholesterol solubility in model bile. Nutr Res 2006;26:579-84.
7. Ash MM, Hang J, Dussault PH, Carr TP. Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters. Nutr Res 2011;31:537-43.
8. Guderian DM, Rasmussen HE, Wray CA, Dussault PH, Carr TP. Cholesterol-lowering properties of plant sterols esterified with beef tallow fatty acids in hamsters. Nutr Res 2007;27:283-8.
9. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993;123:1939-51.
10. Brown AW, Hang J, Dussault PH, Carr TP. Plant sterol and stanol substrate specificity of pancreatic cholesterol esterase. J Nutr Biochem 2010;21:736-40.
11. Carr TP, Andresen CJ, Rudel LL. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem 1993;26:39-42.
12. Merz-Demlow BE, Duncan AM, Wangen KE, Xu X, Carr TP, Phipps WR, Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 2000;71:1462-9.
13. Schneider CL, Cowles RL, Stuefer-Powell CL, Carr TP. Dietary stearic acid reduces cholesterol absorption and increases endogenous cholesterol excretion in hamsters fed cereal-based diets. J Nutr 2000;130:1232-8.
14. Turley SD, Herndon MW, Dietschy JM. Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster. J Lipid Res 1994;35:328-39.
15. Cai G, Carr TP. Biliary cholesterol and bile acid excretion do not increase in hamsters fed cereal-based diets containing cholesterol. Metabolism 1999;48:400-5.
16. Peterson DW, Shneour EA, Peek NF, Gaffey HW. Dietary constituents affecting plasma and liver cholesterol in cholesterol-fed chicks. J Nutr 1953;50:191-201.
17. Best MM, Duncan CH. Effects of the esterification of supplemental cholesterol and sitosterol in the diet. J Nutr 1958;65:169-81.
18. Mattson FH, Volpenhein RA, Erickson BA. Effect of plant sterol esters on the absorption of dietary cholesterol. J Nutr 1977;107:1139-46.
19. Normén L, Ellegard L, Janssen HG, Steenbergen H, Trautwein E, Andersson H. Phytosterol and phytostanol esters are effectively hydrolysed in the gut and do not affect fat digestion in ileostomy subjects. Eur J Nutr 2006;45:165-70.
20. Kobayashi M, Hamada T, Goto H, Imaizumi K, Ikeda I. Comparison of effects of dietary unesterified and esterified plant sterols on cholesterol absorption in rats. J Nutr Sci Vitaminol (Tokyo) 2008;54:210-4.
21. Young SC, Hui DY. Pancreatic lipase/colipase-mediated triacylglycerol hydrolysis is required for cholesterol transport from lipid emulsions to intestinal cells. Biochem J 1999;339:615-20.
22. Huggins KW, Camarota LM, Howles PN, Hui DY. Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. J Biol Chem 2003;278:42899-905.
23. Armstrong MJ, Carey MC. The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities. J Lipid Res 1982;23:70-80.
24. Heuman DM. Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions. J Lipid Res 1989;30:719-30.
25. Carr TP, Cornelison RM, Illston BJ, Stuefer-Powell CL, Gallaher DD. Plant sterols alter bile acid metabolism and reduce cholesterol absorption in hamsters fed a beef-based diet. Nutr Res 2002;22:745-54.
26. Cowles RL, Lee JY, Gallaher DD, Stuefer-Powell CL, Carr TP. Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. J Nutr 2002;132:3119-22.