P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C-N, C-O, and C-C Cross-Coupling Reactions

Organic Letters

Volumn 17, Issue 13, 2015, Pages 3370-3373

  Buitrago Santanilla, Alexander ^a   Christensen, Melodie ^a   Campeau, Louis Charles ^a   Davies, Ian W ^a   Dreher, Spencer D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84935133244     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/acs.orglett.5b01648     Document Type: Article

References (38)

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38. The couplings of amines 6 (with Brettphos Pd G3) and 7 (with RuPhos Pd G2) with bromide 13 have not been reported in the literature at room temperature, so we independently verified that LiHMDS is indeed capable of coupling these nucleophiles at rt (5% catalyst, THF, 1.5 equiv of nucleophile, 2 equiv of base, 18 h).