Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Geier, Martina ^a   Bachler, Thorsten ^a   Hanlon, Steven P ^b   Eggimann, Fabian K ^c   Kittelmann, Matthias ^c   Weber, Hansjörg ^a   Lütz, Stephan ^c   Wirz, Beat ^b   Winkler, Margit ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Drug metabolites; Escherichia coli; Flavin monooxygenase isoform 2; FMO2; Propranolol; Trifluoperazine; Whole cell biocatalysis

Indexed keywords

BENZYDAMINE; BENZYDAMINE N OXIDE; CELL PROTEIN; DRUG METABOLITE; ETHIONAMIDE; ETHIONAMIDE N OXIDE; FLAVIN MONOOXYGENASE ISOFORM 2; OXIDE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; 4,6-DINITRO-O-CRESOL; DINITRO ORTHO CRESOL; DRUG; MIXED FUNCTION OXIDASE; PROPRANOLOL; RECOMBINANT PROTEIN;

ARTICLE; BACTERIUM IDENTIFICATION; BINDING AFFINITY; BINDING SITE; BIOCATALYST; BIOMASS PRODUCTION; BIOTRANSFORMATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME METABOLISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SCREENING TEST; WHOLE CELL CATALYST; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; GENE EXPRESSION; GENETICS; METABOLISM;

ESCHERICHIA COLI;

BIOCATALYSIS; DINITROCRESOLS; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; MIXED FUNCTION OXYGENASES; PHARMACEUTICAL PREPARATIONS; PROPRANOLOL; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRIFLUOPERAZINE;

EID: 84935001735     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0262-0     Document Type: Article

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