Coencapsulation of Hydrophobic and Hydrophilic Antituberculosis Drugs in Synergistic Brij 96 Microemulsions: A Biophysical Characterization

Journal of Pharmaceutical Sciences

Volumn 104, Issue 7, 2015, Pages 2203-2212

  Kaur, Gurpreet ^a   Mehta, S K ^a   Kumar, Sandeep ^b   Bhanjana, Gaurav ^b   Dilbaghi, Neeraj ^b  

^a PANJAB UNIVERSITY   (India)

^b GURU JAMBHESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

anti TB drugs; Brij 96; derivative absorbance spectroscopy; in vitro release; nonionic microemulsions; preformulation; solubility; stability; toxicity; UV visible spectroscopy

Indexed keywords

BRIJ 96; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN; SURFACTANT; UNCLASSIFIED DRUG; EMULSION; MACROGOL DERIVATIVE; OXAZINE DERIVATIVE; POLYOXYETHYLENE OLEYL ETHER; RESAZURIN; TUBERCULOSTATIC AGENT; VEGETABLE OIL; XANTHENE DERIVATIVE;

AGAR DIFFUSION; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; ELECTRIC CONDUCTIVITY; HYDROPHILICITY; HYDROPHOBICITY; MICROEMULSION; MICROENCAPSULATION; NONHUMAN; RESAZURIN ASSAY; ANIMAL; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; CHLOROCEBUS AETHIOPS; EMULSION; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY; VERO CELL LINE;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISONIAZID; OXAZINES; PLANT OILS; POLYETHYLENE GLYCOLS; PYRAZINAMIDE; RIFAMPIN; SOLUBILITY; VERO CELLS; XANTHENES;

EID: 84935000329     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24469     Document Type: Article

References (38)

1. Soussan E, Cassel SP, Blanzat M, Rico-Lattes I,. 2009. Drug delivery by soft matter: Matrix and vesicular carriers. Angew Chem Int Ed 48: 274-288.
2. Liu Y, Wang L, Zhao Y, He M, Zhang X, Niu M, Feng N,. 2014. Nanostructured lipid carriers versus microemulsions for delivery of the poorly water-soluble drug luteolin. Int J Pharm 476: 169-177.
3. Djekic L, Primorac M, Filipic S, Agbab D,. 2012. Investigation of surfactant/cosurfactant synergism impact on ibuprofen solubilization capacity and drug release characteristics of nonionic microemulsions. Int J Pharm 433: 25-33.
4. Tian Q, Ren F, Xu Z, Xie Y, Zhang S,. 2012. Preparation of high solubilizable microemulsion of naproxen and its solubilization mechanism. Int J Pharm 426: 202-210.
5. You X, Xing Q, Tuo J, Song W, Zeng Y, Hu H,. 2014. Optimizing surfactant content to improve oral bioavailability of ibuprofen in microemulsions: Just enough or more than enough? Int J Pharm 471: 276-284.
6. Hoppel M, Ettl H, Holper E, Valenta C,. 2014. Influence of the composition of monoacyl phosphatidylcholine based microemulsions on the dermal delivery of flufenamic acid. Int J Pharm 475: 156-162.
7. Sahle FF, Metz H, Wohlrab J, Neubert RHH,. 2013. Lecithin-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterizations, and in vitro release and penetration studies. Pharm Res 30: 538-551.
8. Mouri A, Diat O, Alain Lerner D, El Ghzaoui A, Ajovalasit A, Dorandeu C, Maurel J, Devoisselle JM, Legrand P,. 2014. Water solubilization capacity of pharmaceutical microemulsions based on Peceol, lecithin and ethanol. Int J Pharm 475: 324-334.
9. Spernath A, Aserin A,. 2006. Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci 47: 128-130.
10. Cooney GF, Jeevanandam V, Choudhury S, Feutren G, Mueller EA, Eisen HJ,. 1998. Comparative bioavailability of neoral and sandimmune in cardiac transplant recipients over 1 year. Transplant Proc 30: 1892-1894.
11. Porter CJH, Charman WN,. 2001. In vitro assessment of oral lipid based formulations. Adv Drug Deliv Rev 50: S127.
12. Lee PJ, Langer R, Shastri VP,. 2003. Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs. Pharm Res 20: 264-269.
13. Singh S, Mariappan TT, Sankar R, Sarda N, Singh B,. 2001. A critical review of the probable reasons for the poor/variable bioavailability of rifampicin from anti-tubercular fixed-dose combination (FDC) products, and the likely solutions to the problem. Int J Pharm 228: 5-17.
14. Shishoo CJ, Shah SA, Rathod IS, Savale SS, Vora MJ,. 2001. Impaired bioavailability of rifampicin in presence of isoniazid from fixed dose combination (FDC) formulation. Int J Pharm 228: 53-67.
15. Agrawal S, Panchagnula R,. 2004. Dissolution test as a surrogate for quality evaluation of rifampicin containing fixed dose combination formulations. Int J Pharm 287: 97-112.
16. Mehta SK, Kaur G, Bhasin KK,. 2010. Entrapment of multiple anti TB drugs in microemulsion system: Quantitative analysis, stability and In vitro release studies. J Pharm Sci 99: 1896-1911.
17. Mehta SK, Kaur G, Bhasin KK,. 2007. Analysis of Tween based microemulsion in the presence of TB drug rifampicin. Colloids Surf B Biointerfaces 60: 95-104.
18. Kaur G,. 2014. Assessment of Brij 96 embedded microemulsions as carrier for anti-tuberculosis drug rifampicin. Mat Focus 3: 18-22.
19. Kaur G, Chiappisi L, Prévost S, Schweins R, Gradzielski M, Mehta SK,. 2012. Probing the microstructure of nonionic microemulsions with ethyl oleate by viscosity, ROESY, DLS, SANS, and cyclic voltammetry. Langmuir 28: 10640-10652.
20. Omotoshjo A, Whatelety L, Florenac ET,. 1989. Methotrexate transport from internal phase of multiple w/o/w emulsion. J Microencapsul 6: 183-192.
21. Kumar S, Bhanjana G, Sharma A, Sidhu MC, Dilbaghi N,. 2014. Synthesis, characterization and on field evaluation of pesticide loaded sodium alginate nanoparticles. Carbohydr Polym 101: 1061-1067.
22. Kumar S, Bhanjana G, Kumar R, Dilbaghi N,. 2013. Synthesis, characterization and antimicrobial activity of nano titanium (IV) mixed ligand complex. Mat Focus 2: 475-481.
23. Mehta SK, Kaur G, Mutneja R, Bhasin KK,. 2009. Solubilization, microstructure, and thermodynamics of fully dilutable U-type Brij microemulsion. J Colloid Interface Sci 338: 542-549.
24. Kaur G, Mehta SK,. 2014. Probing location of anti-TB drugs loaded in Brij 96 microemulsions using thermoanalytical and photophysical approach. J Pharm Sci 103: 937-944.
25. Lagourette B, Peyrelasse J, Boned C, Clausse M,. 1979. Percolative conduction in microemulsion type systems. Nature 281: 60-62.
26. Aliotta F, Migliardo P, Donato DI, Liveri VT, Bardez E, Larry B,. 1992. Local hydration effects in reversed micellar aggregation. Progr Colloid Polym Sci 89: 258-262.
27. Kaler EW, Bennett KE, Davis HT, Scriven LE,. 1983. Toward understanding microemulsion microstructure II. J Chem Phys 79: 5685.
28. El-Laithy HM,. 2003. Preparation and physicochemical characterization of dioctyl sodium sulfosuccinate (aerosol OT) microemulsion for oral drug delivery. AAPS PharmSciTech 4 (1): E11.
29. Gursoy A, Senyucel B,. 1997. Characterization of ciprofloxacin liposomes: Derivative ultraviolet spectrophotometric determinations. J Microencapsul 14: 769-776.
30. Agrawal S, Singh I, Kaur KJ, Bhade SR, Kaul CL, Panchagnula R,. 2004. Comparative bioavailability of rifampicin, isoniazid and pyrazinamide from a four drug fixed dose combination with separate formulations at the same dose levels. Int J Pharm 276: 41-49.
31. Jurkovic P, Sentjurc M, Gasperlin M, Kristl J, Pěcar S,. 2003. Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions. Eur J Pharm Biopharm 56: 59-66.
32. Kreilgaard M,. 2002. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev 54: S77-S98.
33. Zhang L, Sun X, Zhang ZR,. 2005. An investigation on liver-targeting microemulsions of norcantharidin. Drug Deliv 12: 289-295.
34. Dai H, Chen Q, Qin H, Guan Y, Shen D, Hua Y, Tang Y, Xu J,. 2006. A temperature-responsive copolymer hydrogel in controlled drug delivery. Macromolecules 39: 6584-6589.
35. Eisenbrand G, Pool-Zobel B, Balls M, Blaauboer BJ, Boobis A, Carere A, Kevekordes S, Lhuguenot JC, Pieters R, Kleiner J,. 2002. Methods of in vitro toxicology. Food Chem Toxicol 40: 193-236.
36. Warisnoicharoen W, Lansley AB, Lawrence MJ,. 2003. Toxicological evaluation of mixtures of nonionic surfactants, alone and in combination with oil. J Pharm Sci 92: 859-868.
37. Finch RG, Greenwood D, Norrby SR, Whitley RJ,. 2000. Antibiotic and chemotherapy-Anti-infective agents and their use in therapy. 9th ed. Saunders Elsevier, Edinburgh, New York.
38. Fu LM, Liu CSF,. 2002. Is Mycobacterium tuberculosis a closer relative to Gram-positive or Gram-negative bacterial pathogens? Tuberculosis 82: 85-90.