A novel chemical footprinting approach identifies critical lysine residues involved in the binding of receptor-associated protein to cluster II of LDL receptor-related protein

Biochemical Journal

Volumn 468, Issue 1, 2015, Pages 65-72

  Bloem, Esther ^a   Ebberink, Eduard H T M ^a   Van Biggelaar, Maartje Den ^a   Van Zwaan, Carmen Der ^a   Mertens, Koen ^a,b   Meijer, Alexander B ^a,b  

^a SANQUIN RESEARCH   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Footprinting; Ligand binding; Low density lipoprotein (LDL) receptor related protein; Mass spectrometry; Receptor associated protein; Tandem mass tag

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LYSINE; MEMBRANE PROTEIN; RECEPTOR ASSOCIATED PROTEIN; UNCLASSIFIED DRUG; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN ASSOCIATED PROTEIN; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARTICLE; COMPLEX FORMATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOOTPRINTING; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROCEDURES; RAT; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; HUMANS; LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN FOOTPRINTING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RATS; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

EID: 84934996537     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140977     Document Type: Article

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