An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins

Fungal Genetics and Biology

Volumn 81, Issue , 2015, Pages 88-97

  Cary, Jeffrey W ^a   Uka, Valdet ^b   Han, Zheng ^b   Buyst, Dieter ^b   Harris Coward, Pamela Y ^a   Ehrlich, Kenneth C ^a   Wei, Qijian ^a   Bhatnagar, Deepak ^a   Dowd, Patrick F ^c   Martens, Stacey L ^d   Calvo, Ana M ^d   Martins, José C ^b   Vanhaecke, Lynn ^b   Coenye, Tom ^e   De Saeger, Sarah ^b   Di Mavungu, José Diana ^b  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^b GHENT UNIVERSITY   (Belgium)

^c NATIONAL CENTER FOR AGRICULTURAL UTILIZATION RESEARCH   (United States)

^d NORTHERN ILLINOIS UNIVERSITY   (United States)

^e Dept of Pharmaceutical Analysis   (Belgium)

Author keywords

Aspergillus flavus; Gene cluster; High resolution mass spectrometry; Leporin; Natural products; Secondary metabolism

Indexed keywords

2 PYRIDONE DERIVATIVE; IRON COMPLEX; LEPORIN A; LEPORIN B; LEPORIN C; LEPORIN DERIVATIVE; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; PEPTIDE SYNTHASE; PIGMENT; PYRIDONE DERIVATIVE;

ARTICLE; ASPERGILLUS FLAVUS; CONTROLLED STUDY; DOWN REGULATION; FUNGAL STRAIN; GENE CLUSTER; GENE EXPRESSION; GENE OVEREXPRESSION; HYBRID; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHESIS; UPREGULATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTIGENE FAMILY; SECONDARY METABOLISM;

ASPERGILLUS FLAVUS; CHARACIFORMES; FUNGI;

ASPERGILLUS FLAVUS; GENE EXPRESSION REGULATION, FUNGAL; MULTIGENE FAMILY; PEPTIDE SYNTHASES; PIGMENTS, BIOLOGICAL; POLYKETIDE SYNTHASES; PYRIDONES; SECONDARY METABOLISM;

EID: 84934983796     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2015.05.010     Document Type: Article

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