-
1
-
-
74549220692
-
Why is osteoarthritis an age-related disease
-
20129196
-
Shane AA, Loeser RF. Why is osteoarthritis an age-related disease. Best Pract Res Clin Rheumatol. 2010;24:15-26. doi: 10.1016/j.berh.2009.08.006 PMID: 20129196
-
(2010)
Best Pract Res Clin Rheumatol.
, vol.24
, pp. 15-26
-
-
Shane, A.A.1
Loeser, R.F.2
-
2
-
-
84871226206
-
Aging processes and the development of osteoarthritis
-
23080227
-
Loeser RF. Aging processes and the development of osteoarthritis. Curr Opin Rheumatol. 2013;25:108-113. doi: 10.1097/BOR.0b013e32835a9428 PMID: 23080227
-
(2013)
Curr Opin Rheumatol.
, vol.25
, pp. 108-113
-
-
Loeser, R.F.1
-
3
-
-
0031977631
-
Nonenzymatic glycation of collagen in aging and diabetes
-
9572149
-
Reiser KM. Nonenzymatic glycation of collagen in aging and diabetes. Proc Soc Exp Biol Med. 1998;218:23-37. PMID: 9572149
-
(1998)
Proc Soc Exp Biol Med.
, vol.218
, pp. 23-37
-
-
Reiser, K.M.1
-
5
-
-
84878947383
-
Advanced glycation end products induce peroxisome proliferator-activated receptor gamma down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products
-
23776688
-
Chen YJ, Sheu ML, Tsai KS, Yang RS, Liu SH. Advanced glycation end products induce peroxisome proliferator-activated receptor gamma down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products. PLoS One. 2013;8:e66611. doi: 10.1371/journal.pone.0066611 PMID: 23776688
-
(2013)
PLoS One
, vol.8
, pp. e66611
-
-
Chen, Y.J.1
Sheu, M.L.2
Tsai, K.S.3
Yang, R.S.4
Liu, S.H.5
-
6
-
-
79955160610
-
Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogenactivated protein kinases and nuclear factor-kappaB in human osteoarthritis chondrocytes
-
21172926
-
Rasheed Z, Akhtar N, Haqqi TM. Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogenactivated protein kinases and nuclear factor-kappaB in human osteoarthritis chondrocytes. Rheumatology (Oxford). 2011;50:838-851. doi: 10.1093/rheumatology/keq380 PMID: 21172926
-
(2011)
Rheumatology (Oxford)
, vol.50
, pp. 838-851
-
-
Rasheed, Z.1
Akhtar, N.2
Haqqi, T.M.3
-
7
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
8001151
-
Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-1156. PMID: 8001151
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
8
-
-
13444271580
-
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs
-
15692987
-
Kobayashi T, Notoya K, Naito T, Unno S, Nakamura A, Martel-Pelletier J, et al. Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum. 2005;52:479-487. PMID: 15692987
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 479-487
-
-
Kobayashi, T.1
Notoya, K.2
Naito, T.3
Unno, S.4
Nakamura, A.5
Martel-Pelletier, J.6
-
9
-
-
80053141188
-
15-deoxy-Delta (12, 14)-prostaglandin-J2 and ciglitazone inhibit TNF-alpha-induced matrix metalloproteinase 13 production via the antagonism of NF-kappaB activation in human synovial fibroblasts
-
21344384
-
Lin TH, Tang CH, Wu K, Fong YC, Yang RS, Fu WM. 15-deoxy-Delta (12, 14)-prostaglandin-J2 and ciglitazone inhibit TNF-alpha-induced matrix metalloproteinase 13 production via the antagonism of NF-kappaB activation in human synovial fibroblasts. J Cell Physiol. 2011;226:3242-3250. doi: 10. 1002/jcp. 22685 PMID: 21344384
-
(2011)
J Cell Physiol.
, vol.226
, pp. 3242-3250
-
-
Lin, T.H.1
Tang, C.H.2
Wu, K.3
Fong, Y.C.4
Yang, R.S.5
Fu, W.M.6
-
10
-
-
78049307983
-
Advanced glycation end products downregulates peroxisome proliferator-activated receptor gamma expression in cultured rabbit chondrocyte through MAPK pathway
-
20863825
-
Yang Q, Chen C, Wu S, Zhang Y, Mao X, Wang W. Advanced glycation end products downregulates peroxisome proliferator-activated receptor gamma expression in cultured rabbit chondrocyte through MAPK pathway. Eur J Pharmacol. 2010;649:108-114. doi: 10.1016/j.ejphar.2010.09.025 PMID: 20863825
-
(2010)
Eur J Pharmacol.
, vol.649
, pp. 108-114
-
-
Yang, Q.1
Chen, C.2
Wu, S.3
Zhang, Y.4
Mao, X.5
Wang, W.6
-
11
-
-
84872864942
-
Immunopathogenesis of osteoarthritis
-
23360836
-
Haseeb A, Haqqi TM. Immunopathogenesis of osteoarthritis. Clin Immunol. 2013;146:185-196. doi: 10.1016/j.clim.2012.12.011 PMID: 23360836
-
(2013)
Clin Immunol.
, vol.146
, pp. 185-196
-
-
Haseeb, A.1
Haqqi, T.M.2
-
12
-
-
0032761646
-
Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis
-
10587559
-
Chen JR, Takahashi M, Suzuki M, Kushida K, Miyamoto S, Inoue T. Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis. Rheumatology (Oxford). 1999;38:1275-1278. PMID: 10587559
-
(1999)
Rheumatology (Oxford)
, vol.38
, pp. 1275-1278
-
-
Chen, J.R.1
Takahashi, M.2
Suzuki, M.3
Kushida, K.4
Miyamoto, S.5
Inoue, T.6
-
13
-
-
47349107995
-
Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders
-
18566691
-
Cho MC, Lee K, Paik SG, Yoon DY. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Res. 2008;2008:679137. doi: 10.1155/2008/679137 PMID: 18566691
-
(2008)
PPAR Res.
, vol.2008
, pp. 679137
-
-
Cho, M.C.1
Lee, K.2
Paik, S.G.3
Yoon, D.Y.4
-
14
-
-
52749088120
-
The many faces of PPARgamma: Anti-inflammatory by any means
-
18926294
-
Szanto A, Nagy L. The many faces of PPARgamma: anti-inflammatory by any means. Immunobiology. 2008;213:789-803. doi: 10.1016/j.imbio.2008.07.015 PMID: 18926294
-
(2008)
Immunobiology
, vol.213
, pp. 789-803
-
-
Szanto, A.1
Nagy, L.2
-
15
-
-
84878667691
-
Expression of peroxisome proliferator-activated receptors alpha, beta, gamma, and H- and L-prostaglandin D synthase during osteoarthritis in the spontaneous hartley guinea pig and experimental dog models
-
23547214
-
Nebbaki SS, El MFE, Afif H, Kapoor M, Benderdour M, Pelletier JP, et al. Expression of peroxisome proliferator-activated receptors alpha, beta, gamma, and H- and L-prostaglandin D synthase during osteoarthritis in the spontaneous hartley guinea pig and experimental dog models. J Rheumatol. 2013;40:877-890. doi: 10.3899/jrheum.120738 PMID: 23547214
-
(2013)
J Rheumatol.
, vol.40
, pp. 877-890
-
-
Nebbaki, S.S.1
El, M.F.E.2
Afif, H.3
Kapoor, M.4
Benderdour, M.5
Pelletier, J.P.6
-
16
-
-
84875221357
-
Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype
-
23375622
-
Vasheghani F, Monemdjou R, Fahmi H, Zhang Y, Perez G, Blati M, et al. Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. Am J Pathol. 2013;182:1099-1106. doi: 10.1016/j.ajpath.2012.12.012 PMID: 23375622
-
(2013)
Am J Pathol.
, vol.182
, pp. 1099-1106
-
-
Vasheghani, F.1
Monemdjou, R.2
Fahmi, H.3
Zhang, Y.4
Perez, G.5
Blati, M.6
-
17
-
-
34547471112
-
The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: In vivo protective effects mediated through the inhibition of key signaling and catabolic pathways
-
17599749
-
Boileau C, Martel-Pelletier J, Fahmi H, Mineau F, Boily M, Pelletier JP. The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. Arthritis Rheum. 2007;56:2288-2298. PMID: 17599749
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 2288-2298
-
-
Boileau, C.1
Martel-Pelletier, J.2
Fahmi, H.3
Mineau, F.4
Boily, M.5
Pelletier, J.P.6
-
18
-
-
84860450664
-
Association of cartilagespecific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model
-
22131019
-
Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, et al. Association of cartilagespecific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis Rheum. 2012;64:1551-1561. doi: 10.1002/art.33490 PMID: 22131019
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 1551-1561
-
-
Monemdjou, R.1
Vasheghani, F.2
Fahmi, H.3
Perez, G.4
Blati, M.5
Taniguchi, N.6
-
19
-
-
0035508145
-
Effects of peroxisome proliferator-activated receptorgamma (PPAR-gamma) on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes
-
11712859
-
Ji JD, Cheon H, Jun. JB, Choi SJ, Kim YR, Lee YH, et al. Effects of peroxisome proliferator-activated receptorgamma (PPAR-gamma) on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes. J Autoimmun. 2001;17:215-221. PMID: 11712859
-
(2001)
J Autoimmun.
, vol.17
, pp. 215-221
-
-
Ji, J.D.1
Cheon, H.2
Jun, J.B.3
Choi, S.J.4
Kim, Y.R.5
Lee, Y.H.6
-
20
-
-
84871714164
-
PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation
-
23108227
-
Ishibashi Y, Matsui T, Ohta K, Tanoue R, Takeuchi M, Asanuma K, et al. PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation. Microvasc Res. 2013;85:54-58. doi: 10.1016/j.mvr. 2012.10.007 PMID: 23108227
-
(2013)
Microvasc Res.
, vol.85
, pp. 54-58
-
-
Ishibashi, Y.1
Matsui, T.2
Ohta, K.3
Tanoue, R.4
Takeuchi, M.5
Asanuma, K.6
-
21
-
-
85027958993
-
Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products
-
23070070
-
Li F, Cai Z, Chen F, Shi X, Zhang Q, Chen S, et al. Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products. Basic Res Cardiol. 2012;107:306. doi: 10.1007/s00395-012-0306-0 PMID: 23070070
-
(2012)
Basic Res Cardiol.
, vol.107
, pp. 306
-
-
Li, F.1
Cai, Z.2
Chen, F.3
Shi, X.4
Zhang, Q.5
Chen, S.6
-
22
-
-
84862753221
-
Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15
-
22587907
-
Puddu A, Sanguineti R, Durante A, Viviani GL. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012;177:79-84. doi: 10.1016/j.regpep. 2012.05.089 PMID: 22587907
-
(2012)
Regul Pept.
, vol.177
, pp. 79-84
-
-
Puddu, A.1
Sanguineti, R.2
Durante, A.3
Viviani, G.L.4
-
23
-
-
79957553582
-
Pioglitazone suppresses advanced glycation end product-induced expression of plasminogen activator inhibitor-1 in vascular smooth muscle cells
-
21621740
-
Yuan X, Liu N. Pioglitazone suppresses advanced glycation end product-induced expression of plasminogen activator inhibitor-1 in vascular smooth muscle cells. J Genet Genomics. 2011;38:193-200. doi: 10.1016/j.jgg.2011.04.001 PMID: 21621740
-
(2011)
J Genet Genomics.
, vol.38
, pp. 193-200
-
-
Yuan, X.1
Liu, N.2
-
24
-
-
77951737083
-
Resveratrol prevents the impairment of advanced glycosylation end products (AGE) on macrophage lipid homeostasis by suppressing the receptor for AGE via peroxisome proliferator-activated receptor gamma activation
-
20372816
-
Zhang Y, Luo Z, Ma L, Xu Q, Yang Q, Si L. Resveratrol prevents the impairment of advanced glycosylation end products (AGE) on macrophage lipid homeostasis by suppressing the receptor for AGE via peroxisome proliferator-activated receptor gamma activation. Int J Mol Med. 2010;25:729-734. PMID: 20372816
-
(2010)
Int J Mol Med.
, vol.25
, pp. 729-734
-
-
Zhang, Y.1
Luo, Z.2
Ma, L.3
Xu, Q.4
Yang, Q.5
Si, L.6
-
25
-
-
71649112618
-
Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products
-
19917066
-
Liang C, Ren Y, Tan H, He Z, Jiang Q, Wu J, et al. Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products. Br J Pharmacol. 2009;158:1865-1873. doi: 10.1111/j.1476-5381.2009.00450.x PMID: 19917066
-
(2009)
Br J Pharmacol.
, vol.158
, pp. 1865-1873
-
-
Liang, C.1
Ren, Y.2
Tan, H.3
He, Z.4
Jiang, Q.5
Wu, J.6
-
26
-
-
67651099181
-
Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease
-
19646657
-
Yamagishi S, Nakamura K, Matsui T. Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease. Pharmacol Res. 2009;60:174-178. doi: 10.1016/j.phrs.2009.01.006 PMID: 19646657
-
(2009)
Pharmacol Res.
, vol.60
, pp. 174-178
-
-
Yamagishi, S.1
Nakamura, K.2
Matsui, T.3
-
27
-
-
84864493147
-
Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARgamma activity and attenuating oxidative stress
-
22352842
-
Lin J, Tang Y, Kang Q, Feng Y, Chen A. Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARgamma activity and attenuating oxidative stress. Br J Pharmacol. 2012;166:2212-2227. doi: 10.1111/j.1476-5381.2012. 01910.x PMID: 22352842
-
(2012)
Br J Pharmacol.
, vol.166
, pp. 2212-2227
-
-
Lin, J.1
Tang, Y.2
Kang, Q.3
Feng, Y.4
Chen, A.5
-
28
-
-
84864753094
-
PPARgamma agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus
-
22620268
-
Jiang LY, Tang SS, Wang XY, Liu LP, Long Y, Hu M, et al. PPARgamma agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS Neurosci Ther. 2012;18:659-666. doi: 10.1111/j.1755-5949.2012.00341.x PMID: 22620268
-
(2012)
CNS Neurosci Ther.
, vol.18
, pp. 659-666
-
-
Jiang, L.Y.1
Tang, S.S.2
Wang, X.Y.3
Liu, L.P.4
Long, Y.5
Hu, M.6
-
29
-
-
0042887240
-
Advanced glycation endproducts (AGEs) induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases (ERK)
-
12962137
-
Cortizo AM, Lettieri MG, Barrio DA, Mercer N, Etcheverry SB, McCarthy AD. Advanced glycation endproducts (AGEs) induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases (ERK). Mol Cell Biochem. 2003;250:1-10. PMID: 12962137
-
(2003)
Mol Cell Biochem.
, vol.250
, pp. 1-10
-
-
Cortizo, A.M.1
Lettieri, M.G.2
Barrio, D.A.3
Mercer, N.4
Etcheverry, S.B.5
McCarthy, A.D.6
-
30
-
-
0141755110
-
Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs)
-
12969251
-
Dukic-Stefanovic S, Gasic-Milenkovic J, Deuther-Conrad W, Munch G. Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs). J Neurochem. 2003;87:44-55. PMID: 12969251
-
(2003)
J Neurochem.
, vol.87
, pp. 44-55
-
-
Dukic-Stefanovic, S.1
Gasic-Milenkovic, J.2
Deuther-Conrad, W.3
Munch, G.4
-
31
-
-
23644436200
-
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis
-
16052547
-
Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, et al. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005;52:2376-2385. PMID: 16052547
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 2376-2385
-
-
Loeser, R.F.1
Yammani, R.R.2
Carlson, C.S.3
Chen, H.4
Cole, A.5
Im, H.J.6
-
32
-
-
67649644339
-
Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes
-
19445683
-
Rasheed Z, Anbazhagan AN, Akhtar N, Ramamurthy S, Voss FR, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res Ther. 2009;11:R71. doi: 10.1186/ar2700 PMID: 19445683
-
(2009)
Arthritis Res Ther.
, vol.11
, pp. R71
-
-
Rasheed, Z.1
Anbazhagan, A.N.2
Akhtar, N.3
Ramamurthy, S.4
Voss, F.R.5
Haqqi, T.M.6
-
33
-
-
43049162900
-
Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes
-
18285354
-
Nah SS, Choi IY, Lee CK, Oh JS, Kim YG, Moon HB, et al. Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes. Rheumatology (Oxford). 2008;47:425-431. doi: 10.1093/rheumatology/kem376 PMID: 18285354
-
(2008)
Rheumatology (Oxford)
, vol.47
, pp. 425-431
-
-
Nah, S.S.1
Choi, I.Y.2
Lee, C.K.3
Oh, J.S.4
Kim, Y.G.5
Moon, H.B.6
-
34
-
-
34247373125
-
Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes
-
17434489
-
Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK. Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes. FEBS Lett. 2007;581:1928-1932. PMID: 17434489
-
(2007)
FEBS Lett.
, vol.581
, pp. 1928-1932
-
-
Nah, S.S.1
Choi, I.Y.2
Yoo, B.3
Kim, Y.G.4
Moon, H.B.5
Lee, C.K.6
-
35
-
-
84869217946
-
Beta-D-glucoside protects against advanced glycation end products (AGEs) - Mediated diabetic responses by suppressing ERK and inducing PPAR gamma DNA binding
-
23058985
-
Mahali SK, Manna SK. Beta-D-glucoside protects against advanced glycation end products (AGEs) - mediated diabetic responses by suppressing ERK and inducing PPAR gamma DNA binding. Biochem Pharmacol. 2012;84:1681-1690. doi: 10.1016/j.bcp. 2012.09.033 PMID: 23058985
-
(2012)
Biochem Pharmacol.
, vol.84
, pp. 1681-1690
-
-
Mahali, S.K.1
Manna, S.K.2
-
36
-
-
33846590071
-
Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma
-
17101779
-
Burgermeister E, Chuderland D, Hanoch T, Meyer M, Liscovitch M, Seger R. Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol. 2007;27:803-817. PMID: 17101779
-
(2007)
Mol Cell Biol.
, vol.27
, pp. 803-817
-
-
Burgermeister, E.1
Chuderland, D.2
Hanoch, T.3
Meyer, M.4
Liscovitch, M.5
Seger, R.6
|