Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype

American Journal of Pathology

Volumn 182, Issue 4, 2013, Pages 1099-1106

  Vasheghani, Faezeh ^a   Monemdjou, Roxana ^a   Fahmi, Hassan ^a   Zhang, Yue ^a   Perez, Gemma ^a   Blati, Meryem ^a   St Arnaud, René ^b   Pelletier, Jean Pierre ^a   Beier, Frank ^c   Martel Pelletier, Johanne ^a   Kapoor, Mohit ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^c WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; COLLAGENASE 3; CRE RECOMBINASE; CYCLOOXYGENASE 2; DISINTEGRIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SYNDECAN 4; THROMBOSPONDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; FIBROSIS; GENOTYPE; HOMOZYGOTE; IN VIVO STUDY; MONONUCLEAR CELL; MOUSE; NONHUMAN; OSTEOARTHRITIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; REAL TIME POLYMERASE CHAIN REACTION; SYNOVITIS; WILD TYPE;

AGING; ANIMALS; BIOLOGICAL MARKERS; CARTILAGE; FIBROSIS; GENE DELETION; INFLAMMATION; INFLAMMATION MEDIATORS; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; OSTEOARTHRITIS; PHENOTYPE; PPAR GAMMA; SYNOVIAL MEMBRANE;

EID: 84875221357     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.12.012     Document Type: Article

References (36)

1. M.B. Goldring, and S.R. Goldring Osteoarthritis J Cell Physiol 213 2007 626 634
2. S. Tanaka, C. Hamanishi, H. Kikuchi, and K. Fukuda Factors related to degradation of articular cartilage in osteoarthritis: a review Semin Arthritis Rheum 27 1998 392 399
3. M. Attur, J. Samuels, S. Krasnokutsky, and S.B. Abramson Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence? Best Pract Res Clin Rheumatol 24 2010 71 79
4. R.C. Lawrence, D.T. Felson, C.G. Helmick, L.M. Arnold, H. Choi, R.A. Deyo, S. Gabriel, R. Hirsch, M.C. Hochberg, G.G. Hunder, J.M. Jordan, J.N. Katz, H.M. Kremers, and F. Wolfe Estimates of the prevalence of arthritis and other rheumatic conditions in the United States, part II Arthritis Rheum 58 2008 26 35
5. A. Chawla, E.J. Schwarz, D.D. Dimaculangan, and M.A. Lazar Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation Endocrinology 135 1994 798 800
6. W. Sha, K. Thompson, J. South, M. Baron, and A. Leask Loss of PPARgamma expression by fibroblasts enhances dermal wound closure Fibrogenesis Tissue Repair 5 2012 5
7. M. Kapoor, M. McCann, S. Liu, K. Huh, C.P. Denton, D.J. Abraham, and A. Leask Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis Arthritis Rheum 60 2009 2822 2829
8. M. Wu, D.S. Melichian, E. Chang, M. Warner-Blankenship, A.K. Ghosh, and J. Varga Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma Am J Pathol 174 2009 519 533
9. G. Skelhorne-Gross, A.L. Reid, A.J. Apostoli, M.A. Di Lena, R.E. Rubino, N.T. Peterson, M. Schneider, S.K. Sengupta, F.J. Gonzalez, and C.J. Nicol Stromal adipocyte PPARgamma protects against breast tumorigenesis Carcinogenesis 33 2012 1412 1420
10. G. Ding, M. Fu, Q. Qin, W. Lewis, H.W. Kim, T. Fukai, M. Bacanamwo, Y.E. Chen, M.D. Schneider, D.J. Mangelsdorf, R.M. Evans, and Q. Yang Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage Cardiovasc Res 76 2007 269 279
11. M. Jiang, S. Fernandez, W.G. Jerome, Y. He, X. Yu, H. Cai, B. Boone, Y. Yi, M.A. Magnuson, P. Roy-Burman, R.J. Matusik, S.B. Shappell, and S.W. Hayward Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy Cell Death Differ 17 2010 469 481
12. C.Y. Ivashchenko, S.Z. Duan, M.G. Usher, and R.M. Mortensen PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis Am J Physiol Gastrointest Liver Physiol 293 2007 G319 G326
13. A.J. Guri, S.K. Mohapatra, W.T. Horne II, R. Hontecillas, and J. Bassaganya-Riera The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease BMC Gastroenterol 10 2010 60
14. H. Fahmi, J. Martel-Pelletier, J.P. Pelletier, and M. Kapoor Peroxisome proliferator-activated receptor gamma in osteoarthritis Mod Rheumatol 21 2011 1 9
15. C. Boileau, J. Martel-Pelletier, H. Fahmi, F. Mineau, M. Boily, and J.P. Pelletier The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways Arthritis Rheum 56 2007 2288 2298
16. T. Kobayashi, K. Notoya, T. Naito, S. Unno, A. Nakamura, J. Martel-Pelletier, and J.P. Pelletier Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs Arthritis Rheum 52 2005 479 487
17. K. Gong, D. Xing, P. Li, B. Aksut, N. Ambalavanan, Q. Yang, S.E. Nozell, S. Oparil, and Y.F. Chen Hypoxia induces downregulation of PPAR-gamma in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-beta signaling Am J Physiol Lung Cell Mol Physiol 301 2011 L899 L907
18. G.Y. Zhang, T. Cheng, M.H. Zheng, C.G. Yi, H. Pan, Z.J. Li, X.L. Chen, Q. Yu, L.F. Jiang, F.Y. Zhou, X.Y. Li, J.Q. Yang, T.G. Chu, and W.Y. Gao Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro Arch Dermatol Res 301 2009 515 522
19. G.Y. Zhang, C.G. Yi, X. Li, B. Ma, Z.J. Li, X.L. Chen, S.Z. Guo, and W.Y. Gao Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts Br J Dermatol 160 2009 762 770
20. A.K. Ghosh, S. Bhattacharyya, J. Wei, S. Kim, Y. Barak, Y. Mori, and J. Varga Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator FASEB J 23 2009 2968 2977
21. F. Fan, Y. Li, X. Duan, T. Zhao, D. Pan, and H. Chen Rosiglitazone attenuates activation of human Tenon's fibroblasts induced by transforming growth factor-beta1 Graefes Arch Clin Exp Ophthalmol 250 2012 1213 1220
22. Y. Barak, M.C. Nelson, E.S. Ong, Y.Z. Jones, P. Ruiz-Lozano, K.R. Chien, A. Koder, and R.M. Evans PPAR gamma is required for placental, cardiac, and adipose tissue development Mol Cell 4 1999 585 595
23. R. Monemdjou, F. Vasheghani, H. Fahmi, G. Perez, M. Blati, N. Taniguchi, M. Lotz, R. St-Arnaud, J.P. Pelletier, J. Martel-Pelletier, F. Beier, and M. Kapoor Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model Arthritis Rheum 64 2012 1551 1561
24. L. Terpstra, J. Prud'homme, A. Arabian, S. Takeda, G. Karsenty, S. Dedhar, and R. St-Arnaud Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes J Cell Biol 162 2003 139 148
25. S.S. Glasson, M.G. Chambers, W.B. Van Den Berg, and C.B. Little The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the mouse Osteoarthritis Cartilage 18 Suppl 3 2010 S17 S23
26. G. Valverde-Franco, J.P. Pelletier, H. Fahmi, D. Hum, K. Matsuo, B. Lussier, M. Kapoor, and J. Martel-Pelletier In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis Arthritis Rheum 64 2012 3614 3625
27. P.M. van der Kraan, R. Stoop, T.H. Meijers, A.R. Poole, and W.B. van den Berg Expression of type X collagen in young and old C57Bl/6 and Balb/c mice: relation with articular cartilage degeneration Osteoarthritis Cartilage 9 2001 92 100
28. S. Yang, J. Kim, J.H. Ryu, H. Oh, C.H. Chun, B.J. Kim, B.H. Min, and J.S. Chun Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction Nat Med 16 2010 687 693
29. F. Echtermeyer, J. Bertrand, R. Dreier, I. Meinecke, K. Neugebauer, M. Fuerst, Y.J. Lee, Y.W. Song, C. Herzog, G. Theilmeier, and T. Pap Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis Nat Med 15 2009 1072 1076
30. H. Afif, M. Benderdour, L. Mfuna-Endam, J. Martel-Pelletier, J.P. Pelletier, N. Duval, and H. Fahmi Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1beta in articular chondrocytes Arthritis Res Ther 9 2007 R31
31. M. Zemmyo, E.J. Meharra, K. Kuhn, L. Creighton-Achermann, and M. Lotz Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice Arthritis Rheum 48 2003 2873 2880
32. X. Yang, L. Chen, X. Xu, C. Li, C. Huang, and C.X. Deng TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage J Cell Biol 153 2001 35 46
33. E.L. Stattin, Y. Tegner, M. Domellof, and N. Dahl Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature Osteoarthritis Cartilage 16 2008 890 896
34. P.M. van der Kraan, and W.B. van den Berg Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? Osteoarthritis Cartilage 20 2012 223 232
35. A. Plaas, J. Velasco, D.J. Gorski, J. Li, A. Cole, K. Christopherson, and J.D. Sandy The relationship between fibrogenic TGFbeta1 signaling in the joint and cartilage degradation in post-injury osteoarthritis Osteoarthritis Cartilage 19 2011 1081 1090
36. E. Caglayan, B. Stauber, A.R. Collins, C.J. Lyon, F. Yin, J. Liu, S. Rosenkranz, E. Erdmann, L.E. Peterson, R.S. Ross, R.K. Tangirala, and W.A. Hsueh Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis Diabetes 57 2008 2470 2479