Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

ACS Chemical Biology

Volumn 10, Issue 6, 2015, Pages 1511-1520

  Bajaj, Megha ^a   Mamidyala, Sreeman K ^a   Zuegg, Johannes ^a   Begg, Stephanie L ^b   Ween, Miranda P ^b   Luo, Zhenyao ^a   Huang, Johnny X ^a   McEwan, Alastair G ^a   Kobe, Bostjan ^a   Paton, James C ^b   McDevitt, Christopher A ^b   Cooper, Matthew A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ANTIGEN; MANGANESE; PNEUMOCOCCAL SURFACE ANTIGEN A; PNEUMOCOCCAL SURFACE ANTIGEN A INHIBITOR; UNCLASSIFIED DRUG; ZINC ION; ADHESIN; ANTIINFECTIVE AGENT; DIVALENT CATION; LIGAND; LIPOPROTEIN; MOLECULAR LIBRARY; PROTEIN BINDING; PSAA PROTEIN, STREPTOCOCCUS; RECOMBINANT PROTEIN; ZINC;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE BINDING ASSAY; COMPUTER MODEL; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SYNTHESIS; HEK293 CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; METAL BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BIOASSAY; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

ADHESINS, BACTERIAL; ANTI-BACTERIAL AGENTS; ANTIGENS, BACTERIAL; BIOLOGICAL ASSAY; CATIONS, DIVALENT; DRUG DESIGN; DRUG DISCOVERY; LIGANDS; LIPOPROTEINS; MANGANESE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 84934942471     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb501032x     Document Type: Article

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