Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives

European Journal of Medicinal Chemistry

Volumn 101, Issue , 2015, Pages 71-80

  Bi, Yi ^a   Yang, Xiao ^b   Zhang, Tingting ^a,c   Liu, Zeyun ^a   Zhang, Xiaochen ^a   Lu, Jing ^a   Cheng, Keguang ^c   Xu, Jinyi ^d   Wang, Hongbo ^a   Lv, Guangyao ^a   Lewis, Peter John ^b   Meng, Qingguo ^a   Ma, Cong ^b  

^a YANTAI UNIVERSITY   (China)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c GUANGXI NORMAL UNIVERSITY   (China)

^d CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antibacterial activity; NO release; Ocotillol; Synergistic effect; Triterpenoid

Indexed keywords

(20, 24 ) EPOXY 3 BETA (5 NITROOXY PENTANOYL) DAMMARANE 12 BETA,25 DIOL; (20, 24) EPOXY 3 BETA (2 NITROOXY ACETYL) DAMMARANE 12 BETA,25 DIOL; (20, 24) EPOXY 3 BETA (5 NITROOXY PENTANOYL) DAMMARANE 12 BETA,25 DIOL; (20, 24) EPOXY 3 BETA (6 BROMO HEXANOYL) DAMMARANE 12 BETA,25 DIOL; (20, 24) EPOXY 3 BETA (6 NITROOXY HEXANOYL) DAMMARANE 12 BETA,25 DIOL; (20,24) EPOXY 3 BETA {[2 AMINO 6 (N' FMOC)]HEXANOLY} DAMMARANE 12 BETA ,25 DIOL; 4 OXO [(20,24) EPOXY DAMMARANE 12 BETA HYDROXY 3 BETA ] 1 [4 (2 NITRO)ETHYL]BENZ BUTYRATE; 4 OXO [(20,24) EPOXY DAMMARANE 12 BETA HYDROXY 3 BETA ] 1 [4 (2 NITRO)ETHYL]PHENETHYL BUTYRATE; 4 OXO [(20,24) EPOXY DAMMARANE 12 BETA HYDROXY 3 BETA ] 1- [4 (2 NITRO)ETHYL]BENZYL BUTYRATE; ANTIINFECTIVE AGENT; CHLORAMPHENICOL; KANAMYCIN; NITRIC OXIDE; TRITERPENOID; UNCLASSIFIED DRUG; GINSENOSIDE; OCOTILLOL;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SUBSTITUTION REACTION; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GINSENOSIDES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NITRIC OXIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84934917380     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.06.021     Document Type: Article

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