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Volumn 98, Issue 4, 2016, Pages 334-340

FGF23-FGF Receptor/Klotho Pathway as a New Drug Target for Disorders of Bone and Mineral Metabolism

Author keywords

Antibody; Klotho; Osteomalacia; Rickets

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR; KLOTHO PROTEIN; BETA GLUCURONIDASE; FIBROBLAST GROWTH FACTOR;

EID: 84934783748     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-015-0029-y     Document Type: Review
Times cited : (42)

References (47)
  • 1
    • 67649227047 scopus 로고    scopus 로고
    • Bone as an endocrine organ
    • COI: 1:CAS:528:DC%2BD1MXnvVahsLw%3D, PID: 19546009
    • Fukumoto S, Martin TJ (2009) Bone as an endocrine organ. Trends Endocrinol Metab 20:230–236
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 230-236
    • Fukumoto, S.1    Martin, T.J.2
  • 2
    • 78049463249 scopus 로고    scopus 로고
    • Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
    • COI: 1:CAS:528:DC%2BC3cXhtlCrsb7J, PID: 20844473
    • Hasegawa H, Nagano N, Urakawa I, Yamazaki Y, Iijima K, Fujita T, Yamashita T, Fukumoto S, Shimada T (2010) Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int 78:975–980
    • (2010) Kidney Int , vol.78 , pp. 975-980
    • Hasegawa, H.1    Nagano, N.2    Urakawa, I.3    Yamazaki, Y.4    Iijima, K.5    Fujita, T.6    Yamashita, T.7    Fukumoto, S.8    Shimada, T.9
  • 3
    • 79953037867 scopus 로고    scopus 로고
    • Anti-FGF23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice
    • COI: 1:CAS:528:DC%2BC3MXlvFymsb4%3D, PID: 20939065
    • Aono Y, Hasegawa H, Yamazaki Y, Shimada T, Fujita T, Yamashita T, Fukumoto S (2011) Anti-FGF23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice. J Bone Miner Res 26:803–810
    • (2011) J Bone Miner Res , vol.26 , pp. 803-810
    • Aono, Y.1    Hasegawa, H.2    Yamazaki, Y.3    Shimada, T.4    Fujita, T.5    Yamashita, T.6    Fukumoto, S.7
  • 6
    • 79960636583 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice
    • COI: 1:CAS:528:DC%2BC3MXhtVejtL%2FL, PID: 21472778
    • Ranch D, Zhang MY, Portale AA, Perwad F (2011) Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice. J Bone Miner Res 26:1883–1890
    • (2011) J Bone Miner Res , vol.26 , pp. 1883-1890
    • Ranch, D.1    Zhang, M.Y.2    Portale, A.A.3    Perwad, F.4
  • 9
    • 84859385905 scopus 로고    scopus 로고
    • Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice
    • COI: 1:CAS:528:DC%2BC38XlsVSmsL4%3D, PID: 22334725
    • Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale AA, Perwad F (2012) Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology 153:1806–1816
    • (2012) Endocrinology , vol.153 , pp. 1806-1816
    • Zhang, M.Y.1    Ranch, D.2    Pereira, R.C.3    Armbrecht, H.J.4    Portale, A.A.5    Perwad, F.6
  • 12
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • The ADHR Consortium (2000) Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26:345–348
    • (2000) Nat Genet , vol.26 , pp. 345-348
  • 15
    • 1642416884 scopus 로고    scopus 로고
    • Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF-23 in phosphate and vitamin D metabolism
    • COI: 1:CAS:528:DC%2BD2cXhsFKhsbs%3D, PID: 14966565
    • Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF-23 in phosphate and vitamin D metabolism. J Clin Invest 113:561–568
    • (2004) J Clin Invest , vol.113 , pp. 561-568
    • Shimada, T.1    Kakitani, M.2    Yamazaki, Y.3    Hasegawa, H.4    Takeuchi, Y.5    Fujita, T.6    Fukumoto, S.7    Tomizuka, K.8    Yamashita, T.9
  • 16
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • COI: 1:CAS:528:DC%2BD2cXhtVaqsLnI, PID: 15579309
    • Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Juppner H, Lanske B (2004) Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 23:421–432
    • (2004) Matrix Biol , vol.23 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6    Juppner, H.7    Lanske, B.8
  • 20
    • 84892774990 scopus 로고    scopus 로고
    • Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion
    • PID: 24348262
    • Olauson H, Lindberg K, Amin R, Sato T, Jia T, Goetz R, Mohammadi M, Andersson G, Lanske B, Larsson TE (2013) Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. PLoS Genet 9:e1003975
    • (2013) PLoS Genet , vol.9 , pp. e1003975
    • Olauson, H.1    Lindberg, K.2    Amin, R.3    Sato, T.4    Jia, T.5    Goetz, R.6    Mohammadi, M.7    Andersson, G.8    Lanske, B.9    Larsson, T.E.10
  • 21
    • 0016589526 scopus 로고
    • Regulation of serum 1alpha, 25-dihydroxyvitamin D3 by calcium and phosphate in the rat
    • COI: 1:CAS:528:DyaE28XivFSk, PID: 1188357
    • Hughes MR, Brumbaugh PF, Hussler MR, Wergedal JE, Baylink DJ (1975) Regulation of serum 1alpha, 25-dihydroxyvitamin D3 by calcium and phosphate in the rat. Science 190:578–580
    • (1975) Science , vol.190 , pp. 578-580
    • Hughes, M.R.1    Brumbaugh, P.F.2    Hussler, M.R.3    Wergedal, J.E.4    Baylink, D.J.5
  • 22
    • 34249664523 scopus 로고    scopus 로고
    • FGF23 concentrations vary with disease status in autosomal dominant hypophosphatemic rickets
    • COI: 1:CAS:528:DC%2BD2sXpt1Grtrs%3D, PID: 17227222
    • Imel EA, Hui SL, Econs MJ (2007) FGF23 concentrations vary with disease status in autosomal dominant hypophosphatemic rickets. J Bone Miner Res 22:520–526
    • (2007) J Bone Miner Res , vol.22 , pp. 520-526
    • Imel, E.A.1    Hui, S.L.2    Econs, M.J.3
  • 25
    • 43149103153 scopus 로고    scopus 로고
    • Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement
    • COI: 1:CAS:528:DC%2BD1cXmtValu7Y%3D, PID: 18396126
    • Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T (2008) Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement. Bone 42:1235–1239
    • (2008) Bone , vol.42 , pp. 1235-1239
    • Endo, I.1    Fukumoto, S.2    Ozono, K.3    Namba, N.4    Tanaka, H.5    Inoue, D.6    Minagawa, M.7    Sugimoto, T.8    Yamauchi, M.9    Michigami, T.10    Matsumoto, T.11
  • 30
    • 13544270218 scopus 로고    scopus 로고
    • An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia
    • COI: 1:CAS:528:DC%2BD2MXkt1Wktw%3D%3D, PID: 15590700
    • Benet-Pages A, Orlik P, Strom TM, Lorenz-Depiereux B (2005) An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet 14:385–390
    • (2005) Hum Mol Genet , vol.14 , pp. 385-390
    • Benet-Pages, A.1    Orlik, P.2    Strom, T.M.3    Lorenz-Depiereux, B.4
  • 32
    • 33645247448 scopus 로고    scopus 로고
    • Management of secondary hyperparathyroidism
    • PID: 16109140
    • Cunningham J (2005) Management of secondary hyperparathyroidism. Ther Apher Dial 9(1):S35–S40
    • (2005) Ther Apher Dial , vol.9 , Issue.1 , pp. S35-S40
    • Cunningham, J.1
  • 37
    • 0141525564 scopus 로고    scopus 로고
    • Serum FGF23 levels in normal and disordered phosphorus homeostasis
    • COI: 1:CAS:528:DC%2BD3sXlsFGktL0%3D, PID: 12854832
    • Weber TJ, Liu S, Indridason OS, Quarles LD (2003) Serum FGF23 levels in normal and disordered phosphorus homeostasis. J Bone Miner Res 18:1227–1234
    • (2003) J Bone Miner Res , vol.18 , pp. 1227-1234
    • Weber, T.J.1    Liu, S.2    Indridason, O.S.3    Quarles, L.D.4
  • 38
    • 83155175328 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 as a phosphotropic hormone and beyond
    • COI: 1:CAS:528:DC%2BC3MXhtFyms7%2FI, PID: 21822586
    • Fukumoto S, Shimizu Y (2011) Fibroblast growth factor 23 as a phosphotropic hormone and beyond. J Bone Miner Metab 29:507–514
    • (2011) J Bone Miner Metab , vol.29 , pp. 507-514
    • Fukumoto, S.1    Shimizu, Y.2
  • 40
    • 0030938927 scopus 로고    scopus 로고
    • Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice
    • COI: 1:CAS:528:DyaK2sXhvFyit7g%3D, PID: 9077527
    • Beck L, Soumounou Y, Martel J, Krishnamurthy G, Gauthier C, Goodyer CG, Tenenhouse HS (1997) Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice. J Clin Invest 99:1200–1209
    • (1997) J Clin Invest , vol.99 , pp. 1200-1209
    • Beck, L.1    Soumounou, Y.2    Martel, J.3    Krishnamurthy, G.4    Gauthier, C.5    Goodyer, C.G.6    Tenenhouse, H.S.7
  • 42
    • 84875421249 scopus 로고    scopus 로고
    • Exploring mechanisms of FGF signalling through the lens of structural biology
    • COI: 1:CAS:528:DC%2BC3sXitlentr8%3D, PID: 23403721
    • Goetz R, Mohammadi M (2013) Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol 14:166–180
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 166-180
    • Goetz, R.1    Mohammadi, M.2
  • 45
    • 29144475911 scopus 로고    scopus 로고
    • Sevelamer hydrochloride and calcium bicarbonate reduce serum fibroblast growth factor 23 levels in dialysis patients
    • COI: 1:CAS:528:DC%2BD2MXhtVyisb3F, PID: 16076378
    • Koiwa F, Kazama JJ, Tokumoto A, Onoda N, Kato H, Okada T, Nii-Kono T, Fukagawa M, Shigematsu T (2005) Sevelamer hydrochloride and calcium bicarbonate reduce serum fibroblast growth factor 23 levels in dialysis patients. Ther Apher Dial 9:336–339
    • (2005) Ther Apher Dial , vol.9 , pp. 336-339
    • Koiwa, F.1    Kazama, J.J.2    Tokumoto, A.3    Onoda, N.4    Kato, H.5    Okada, T.6    Nii-Kono, T.7    Fukagawa, M.8    Shigematsu, T.9
  • 46
    • 84907896361 scopus 로고    scopus 로고
    • Long-term sevelamer treatment lowers serum fibroblast growth factor 23 accompanied with increasing serum Klotho levels in chronic haemodialysis patients
    • COI: 1:CAS:528:DC%2BC2cXhslCqtrvL
    • Lin HH, Liou HH, Wu MS, Lin CY, Huang CC (2014) Long-term sevelamer treatment lowers serum fibroblast growth factor 23 accompanied with increasing serum Klotho levels in chronic haemodialysis patients. Nephrology (Carlton) 19:672–678
    • (2014) Nephrology (Carlton) , vol.19 , pp. 672-678
    • Lin, H.H.1    Liou, H.H.2    Wu, M.S.3    Lin, C.Y.4    Huang, C.C.5
  • 47
    • 31544450766 scopus 로고    scopus 로고
    • Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats
    • COI: 1:CAS:528:DC%2BD28XnsV2ltA%3D%3D, PID: 16395276
    • Nagano N, Miyata S, Abe M, Kobayashi N, Wakita S, Yamashita T, Wada M (2006) Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats. Kidney Int 69:531–537
    • (2006) Kidney Int , vol.69 , pp. 531-537
    • Nagano, N.1    Miyata, S.2    Abe, M.3    Kobayashi, N.4    Wakita, S.5    Yamashita, T.6    Wada, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.