Modification of autophagy-lysosomal pathway as a neuroprotective treatment for spinal cord injury

Neural Regeneration Research

Volumn 10, Issue 6, 2015, Pages 892-893

  Lipinski, Marta M ^a   Wu, Junfang ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 12; CASPASE 3; CATHEPSIN D; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN AGGREGATE; PROTEIN P62; PROTEINASE; RAPAMYCIN;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM STRESS; GLIA CELL; HUMAN; LYSOSOME; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN DEGRADATION; SPINAL CORD INJURY;

EID: 84934761143     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.158344     Document Type: Article

References (14)

1. Beattie MS, Hermann GE, Rogers RC, Bresnahan JC (2002) Cell death in models of spinal cord injury. Prog Brain Res 137:37-47.
2. Bercury KK, Dai J, Sachs HH, Ahrendsen JT, Wood TL, Macklin WB (2014) Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. J Neurosci 34:4466-4480.
3. Bove J, Martinez-Vicente M, Vila M (2011) Fighting neurodegeneration with rapamycin: mechanistic insights. Nat Rev Neurosci 12:437-452.
4. Boyce M, Lipinski MM, Py BF, Yuan J (2011) Endoplasmic reticulum stress response in cell death and cell survival. In: Apoptosis: Physiology and Pathology, 1 Edition (Reed JC, Green DR, eds), pp 51-62. Cambridge: Cambridge University Press.
5. Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK (2014) Mammalian target of rapamycin’s distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS. J Neurosci 34:15347-15355.
6. Lipinski MM, Wu J, Faden AI, Sarkar S (2015) Function and mechanisms of autophagy in brain and spinal cord trauma. Antioxid Redox Signal doi:10.1089/ars.2015.6306.
7. Liu S, Sarkar S, Dinizo M, Faden AI, Koh EY, Lipinski MM, Wu J (2015) Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis 6:e1582.
8. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075.
9. Ohri SS, Hetman M, Whittemore SR (2013) Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury. Neurobiol Dis 58:29-37.
10. Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 322:963-966.
11. Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J (2011) Regulation of TFEB and V-ATPases by mTORC1. EMBO J 30:3242-3258.
12. Smith CM, Mayer JA, Duncan ID (2013) Autophagy promotes oligodendrocyte survival and function following dysmyelination in a long-lived myelin mutant. J Neurosci 33:8088-8100.
13. Wahl SE, McLane LE, Bercury KK, Macklin WB, Wood TL (2014) Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci 34:4453-4465.
14. White E, Karp C, Strohecker AM, Guo Y, Mathew R (2010) Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol 22:212-217.