Microanatomy of the cervical and anorectal squamocolumnar junctions: A proposed model for anatomical differences in HPV-related cancer risk

Modern Pathology

Volumn 28, Issue 7, 2015, Pages 994-1000

  Yang, Eric J ^a   Quick, Matthew C ^b   Hanamornroongruang, Suchanan ^c   Lai, Keith ^b   Doyle, Leona A ^a   McKeon, Frank D ^d   Xian, Wa ^d   Crum, Christopher P ^a   Herfs, Michael ^e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF ARKANSAS MEDICAL CENTER   (United States)

^c MAHIDOL UNIVERSITY   (Thailand)

^d JACKSON LABORATORY   (United States)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANAL CANAL; ANUS TUMOR; CARCINOMA IN SITU; EPITHELIUM; FEMALE; FETUS; HUMAN; METAPLASIA; PAPILLOMAVIRUS INFECTION; PATHOLOGY; SQUAMOUS INTRAEPITHELIAL LESION OF THE CERVIX; UTERINE CERVIX; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX TUMOR; VIROLOGY;

ADULT; ANAL CANAL; ANUS NEOPLASMS; CARCINOMA IN SITU; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; EPITHELIUM; FEMALE; FETUS; HUMANS; METAPLASIA; PAPILLOMAVIRUS INFECTIONS; SQUAMOUS INTRAEPITHELIAL LESIONS OF THE CERVIX; UTERINE CERVICAL NEOPLASMS;

EID: 84934441151     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2015.54     Document Type: Article

References (26)

1. Bosch FX, Lorincz A, Munõz N et al. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002;55:244-265.
2. Ferenczy A, Franco E. Persistent human papillomavirus infection and cervical neoplasia. Lancet Oncol 2002;3:11-16.
3. Crum CP, Ikenberg H, Richart RM et al. Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med 1984;310:880-883.
4. Marsh M. Original site of cervical carcinoma; topographical relationship of carcinoma of the cervix to the external os and to the squamocolumnar junction. Obstet Gynecol 1956;7:444-452.
5. Wang X, Ouyang H, Yamamoto Y et al. Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell 2011;145:1023-1035.
6. Herfs M, Yamamoto Y, Laury A et al. A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci USA 2012;109:10516-10521.
7. Chaturvedi AK. Beyond cervical cancer: burden of other HPV-related cancers among men and women. J Adolesc Health 2010;46:S20-S26.
8. Frisch M, Glimelius B, van den Brule AJ et al. Sexually transmitted infection as a cause of anal cancer. N Engl J Med 1997;337:1350-1358.
9. Tilston P. Anal human papillomavirus and anal cancer. J Clin Pathol 1997;50:625-634.
10. Ryan DP, Compton CC, Mayer RJ. Carcinoma of the anal canal. N Engl J Med 2000;342:792-800.
11. Clark MA, Hartley A, Geh JI. Cancer of the anal canal. Lancet Oncol 2004;5:149-157.
12. Parkin DM. The global health burden of infectionassociated cancers in the year 2002. Int J Cancer 2006; 118:3030-3044.
13. Forman D, de Martel C, Lacey CJ et al. Global burden of human papillomavirus and related diseases. Vaccine 2012;30:F12-F23.
14. Palefsky JM, Holly EA, Ralston ML et al. Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and highrisk HIV-negative women. J Infect Dis 2001;183:383-391.
15. Williams AB, Darragh TM, Vranizan K et al. Anal and cervical human papillomavirus infection and risk of anal and cervical epithelial abnormalities in human immunodeficiency virus-infected women. Obstet Gynecol 1994;83:205-211.
16. Hernandez BY, McDuffie K, Zhu X et al. Anal human papillomavirus infection in women and its relationship with cervical infection. Cancer Epidemiol Biomark Prev 2005;14:2550-2556.
17. Fenger C. The anal transitional zone. A method for macroscopic demonstration. Acta Pathol Microbiol Scand [A] 1978;86:225-230.
18. Herfs M, Vargas SO, Yamamoto Y et al. A novel blueprint for "top down" differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia. J Pathol 2013;229:460-468.
19. Xian W, Ho KY, Crum CP et al. Cellular origin of Barrett's esophagus: controversy and therapeutic implications. Gastroenterology 2012;142:1424-1430.
20. Odze RD. Unraveling the mystery of the gastroesophageal junction: a pathologist's perspective. Am J Gastroenterol 2005;100:1853-1867.
21. Williams GR, Talbot IC, Northover JM et al. Keratin expression in the normal anal canal. Histopathology 1995;26:39-44.
22. Williams GR, Talbot IC, Leigh IM. Keratin expression in anal carcinoma: an immunohistochemical study. Histopathology 1997;30:443-450.
23. Fritsch H, Zehm S, Illig R et al. New insights into the development and differentiation of the human anorectal epithelia. Are there clinical consequences? Int J Colorectal Dis 2010;25: 1231-1242.
24. Roberts JN, Buck CB, Thompson CD et al. Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan. Nat Med 2007;13:857-861.
25. Letian T, Tianyu Z. Cellular receptor binding and entry of human papillomavirus. Virol J 2010;7:2.
26. Huang H-S, Lambert PF. Use of an in vivo animal model for assessing the role of integrin (6) (4) and syndecan-1 in early steps in papillomavirus infection. Virology 2012;433:395-400.