New insights into the development and differentiation of the human anorectal epithelia. Are there clinical consequences?

International Journal of Colorectal Disease

Volumn 25, Issue 10, 2010, Pages 1231-1242

  Fritsch, Helga ^a   Zehm, Sarah ^a   Illig, Romana ^a   Moser, Patrizia ^b   Aigner, Felix ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Anorectal tumours; CDX2; Cytokeratins; Epithelial differentiation; Human rectum

Indexed keywords

CYTOKERATIN 18; CYTOKERATIN 20; CYTOKERATIN 7; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR CDX2;

ADULT; AGED; ANUS CARCINOMA; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CHILD; CONTROLLED STUDY; FEMALE; FETUS; HISTOPATHOLOGY; HUMAN; IMMUNOREACTIVITY; INTESTINE EPITHELIUM CELL; MALE; NEWBORN; PHASE TRANSITION; PRENATAL GROWTH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CARCINOMA; SQUAMOUS EPITHELIUM;

ADULT; ANAL CANAL; ANUS NEOPLASMS; CHILD, PRESCHOOL; EPITHELIAL CELLS; EPITHELIUM; FETUS; HOMEODOMAIN PROTEINS; HUMANS; RECTAL NEOPLASMS; RECTUM;

EID: 77956183762     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-010-0986-6     Document Type: Article

References (34)

1. Böcker W, Denk H, Heitz PU (1996) Pathologie. Urban & Fischer
2. GG Grabenbauer H Kessler KE Matzel R Sauer W Hohenberger ICH Schneider 2005 Tumor site predicts outcome after radiochemotherapy in squamous-cell carcinoma of anal region: long-term results of 101 patients Dis Colon Rectum 48 1742 1751 10.1007/s10350-005-0098-5 15991058
3. P Hermanek S Merkel 2007 Pathology and classification of anal carcinomas Der Onkologe 13 982 992 10.1007/s00761-007-1269-x
4. Fenger C (1997) Anal canal. In: Sternberg SS (ed) Histology for Pathologists. Lippincott-Raven Publishers
5. FP Johnson 1914 The development of the rectum in the human embryo Am J Anat 16 1 57 10.1002/aja.1000160102
6. st German edition. Verlag Hans Huber
7. Sadler T (2004) Langman's medical embryology. Lippincott Williams and Wilkins Philadelphia Baltimore New York London Buenos Aires Hong Kong Sydney Tokyo pp. 313-317
8. Standring S (2005) editor in chief. Gray's Anatomy. 39th ed. Elsevier Churchill Livingstone
9. Stelzner F (1998) Chirurgie an viszeralen Abschlusssystemen. Georg Thieme Stuttgart New York
10. H Fritsch F Aigner B Ludwikowski S Reinstadler-Zankl R Illig D Urbas C Schwarzer S Longato 2007 Epithelial and muscular regionalization of the human developing anorectum Anat Rec 290 1449 1458 10.1002/ar.20589
11. SD Bernal RA Stahel 1985 Cytoskeleton-associated proteins: their role as cellular integrators in the neoplastic process Crit Rev Oncol Hematol 3 191 204 10.1016/S1040-8428(85)80026-3 1:STN:280:DyaL28%2Fgt1Gkug%3D%3D 2412718
12. R Moll WW Franke DL Schiller B Geiger R Krepler 1982 The catalogue of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells Cell 31 11 24 10.1016/0092-8674(82)90400-7 1:CAS:528: DyaL3sXhtlSjsw%3D%3D 6186379
13. F Ramaekers J Puts A Kant O Moesker P Jap P Vooijs 1982 Differential diagnosis of human carcinomas, sarcomas and their metastases using antibodies to intermediate-sized filaments Eur J Cancer Clin Oncol 18 1251 1257 10.1016/0277-5379(82)90126-2 1:STN:280:DyaL3s7lslOgsg%3D%3D 6187573
14. SC Tseng MJ Jarvinen WG Nelson JW Huang J Woodcock-Mitchell TT Sun 1982 Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies Cell 30 361 372 10.1016/0092-8674(82)90234-3 1:CAS:528:DyaL38Xlsl2ht7g%3D 6183000
15. TT Sun R Eichner WG Nelson, et al. 1983 Keratin classes: molecular markers for different types of epithelial differentiation J Invest Dermatol 81 109 115 10.1111/1523-1747.ep12540831
16. R Moll 1993 Cytokeratins as markers of differentiation. Expression profiles in epithelia and epithelial tumors Veroeff Pathol 142 1 197 1:STN:280:DyaK2c%2FnvVKlsA%3D%3D
17. A Erol LS Baskin YW Li WH Liu 2000 Anatomical studies of the urethral plate: why preservation of the urethral plate is important in hypospadias repair BJU Int 85 728 734 10.1046/j.1464-410x.2000.00486.x 1:STN:280: DC%2BD3c3itl2gsQ%3D%3D 10759675
18. HC Ee T Erler PS Bhathal GP Young RJ James 1995 Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma AJP 147 586 592 1:CAS:528:DyaK2MXoslKjsLg%3D 7677172
19. V Kaimaktchiev L Terraccioano L Tornillo H Spichtin D Stoios M Bundi V Korcheva M Mirlacher M Loda G Sauter CL Corless 2004 The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas Mod Pathol 17 1392 1399 10.1038/modpathol.3800205 1:CAS:528:DC%2BD2cXhtVWltL3E 15205684
20. RW Werling H Yaziji CE Bacchi AM Gown 2003 CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin; an immunohistochemical survey of 476 primary and metastatic carcinomas Am J Surg Pathol 27 303 310 10.1097/00000478-200303000-00003 12604886
21. M Barbareschi B Murer TV Colby M Chilosi E Macri M Loda C Doglioni 2003 CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs Am J Surg Pathol 27 141 149 10.1097/00000478-200302000- 00001 1:STN:280:DC%2BD3s%2FjvV2kuw%3D%3D 12548159
22. PA de Vries GW Friedland 1974 The staged sequential development of the anus and rectum in human embryos and foetuses J Pediatr Surg 9 755 769 10.1016/0022-3468(74)90115-8 4424274
23. SC van der Putte 2005 The development of the perineum in the human. A comprehensive histological study with a special reference to the role of the stromal components Adv Anat Embryol Cell Biol 177 1 131 10.1007/3-540-26783-2-1 15615037
24. SC van der Putte 2009 The development of the human anorectum Anat Rec 292 951 954 10.1002/ar.20914
25. Patten BM (1953) Human Embryology, 2nd edn. Mc Graw-Hill Book Company
26. P Kromer E Korzeniowska-Kromer 2003 Anal canal development in the embryonic and early foetal period Folia Morphol (Warsz) 62 285 287
27. Hollinshead WH (1956) Anatomy for surgeons: the thorax, abdomen and pelvis. Hoeber-Harper
28. K Yamaguchi J Kiyokawa K Akita 2008 Developmental process and ectodermal contribution to the anal canal in mice Ann Anat 190 119 128 10.1016/j.aanat. 2007.08.001 18413265
29. RS Saad JF Silverman MA Khalifa C Rowsell 2009 CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma Appl Immunhistochem Mol Morphol 17 196 201 10.1097/PAI.0b013e31819268f2 1:CAS:528:DC%2BD1MXkvVWmsro%3D
30. rd edition. Springer-Verlag Berlin Heidelberg
31. A Goel I Gupta K Joshi 1997 Immunohistochemical analysis of human embryos and fetuses: an insight into the mechanism of subversion of antigenic differentiation in neoplasia Arch Pathol Lab Med 121 719 723 1:STN:280:DyaK2szot12itQ%3D%3D 9240908
32. N Gao P White KH Kaestner 2009 Establishment of intestinal identity and epithelial-mesenchymal signalling by Cdx2 Dev Cell 16 588 599 10.1016/j.devcel.2009.02.010 1:CAS:528:DC%2BD1MXlsFaisbg%3D 19386267
33. I Gross I Duluc T Benameur A Calon E Martin T Brabletz M Kedinger C Domon-Dell JN Freund 2008 The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells Oncogene 27 107 115 10.1038/sj.onc.1210601 1:CAS:528:DC%2BD1cXhtlSntw%3D%3D 17599044
34. S Bakaris A Cetinkaya F Ezberci H Ekerbicer 2008 Expression of homedomain protein CDX2 in colorectal adenoma and adenocarcinoma Histol Histopathol 23 1043 1047 18581275