Effect of alternate energy substrates on mammalian brain metabolism during ischemic events

Advances in Experimental Medicine and Biology

Volumn 614, Issue , 2008, Pages 361-370

  Koppaka, S S ^a,b   Puchowicz, M A ^b,c   Lamanna, J C ^b,c   Gatica, J E ^a,b  

^a Cleveland State University

^b Center for Modeling Integrated Metabolic Systems (MIMS)   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; KETONE BODY; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ACTIVE TRANSPORT; ASTROCYTE; BRAIN CAPILLARY; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN NERVE CELL; BRAIN PERFUSION; CELL METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSOL; EXTRACELLULAR SPACE; MATHEMATICAL MODEL; MITOCHONDRION; PASSIVE TRANSPORT; PRIORITY JOURNAL; RESUSCITATION; SIMULATION;

MAMMALIA;

EID: 84934439034     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-74911-2_40     Document Type: Conference Paper

References (22)

1. C. P. Chih and E. L. Roberts Jr, Energy substrates for neurons during neural activity: a critical review of the astrocyte-neuron lactate shuttle hypothesis, J Cereb Blood Flow Metab 23(11), 1263-1281 (2003).
2. R. L. Leino, D. Z. Gerhart, A. M. van Bueren, A. L. McCall, and L. R. Drewes, Ultrastructural localization of GLUT 1 and GLUT 3 glucose transporters in rat brain, J Neurosci Res 49(5), 617-626 (1997).
3. D. Z. Gerhart, B. E. Enerson, O. Y. Zhdankina, R. L. Leino, and L. R. Drewes, Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats, Am J Physiol 273(1 Pt 1), E207-E213 (1997).
4. P. J. Magistretti, L. Pellerin, D. L. Rothman, and R. G. Shulman, Energy on demand, Science 283(5401), 496-497 (1999).
5. L. Pellerin and P. J. Magistretti, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc Natl Acad Sci U S A 91(22), 10625-10629 (1994).
6. G. A. Dienel and L. Hertz, Glucose and lactate metabolism during brain activation, J Neurosci Res 66(5), 824-838 (2001).
7. A. Gjedde, S. Marrett, and M. Vafaee, Oxidative and nonoxidative metabolism of excited neurons and astrocytes, J Cereb Blood Flow Metab 22(1), 1-14 (2002).
8. A. Aubert, R. Costalat, and R. Valabregue, Modelling of the coupling between brain electrical activity and metabolism, Acta Biotheor 49(4), 301-326 (2001).
9. A. Aubert and R. Costalat, Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism, J Cereb Blood Flow Metab 25(11), 1476-1490 (2005).
10. F. Hyder, A. B. Patel, A. Gjedde, D. L. Rothman, K. L. Behar, and R. G. Shulman, Neuronal-glial glucose oxidation and glutamatergic-GABAergic function, J Cereb Blood Flow Metab 26(7), 865-877 (2006).
11. O. H. Lowry and J. V. Passonneau, The relationship between substrates and enzymes of glycolysis in brain, J Biol Chem 239, 31-42 (1964).
12. B. K. Siesjo, Brain Energy Metabolism, (John Wiley & Sons, New York, 1978).
13. O. E. Owen, A. P. Morgan, H. G. Kemp, J. M. Sullivan, M. G. Herrera, and G. F. Cahill, Jr., Brain metabolism during fasting, J Clin Invest 46(10), 1589-1595 (1967).
14. D. Z. Gerhart, B. E. Enerson, O. Y. Zhdankina, R. L. Leino, and L. R. Drewes, Expression of the monocarboxylate transporter MCT2 by rat brain glia, Glia 22(3), 272-281 (1998).
15. R. L. Veech, B. Chance, Y. Kashiwaya, H. A. Lardy, and G. F. Cahill, Jr., Ketone bodies, potential therapeutic uses, IUBMB Life 51(4), 241-247 (2001).
16. Y. Kashiwaya, T. Takeshima, N. Mori, K. Nakashima, K. Clarke, and R. L. Veech, D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease, Proc Natl Acad Sci U S A 97(10), 5440-5444 (2000).
17. M. Guzman and C. Blazquez, Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol Metab 12(4), 169-173 (2001).
18. H. S. Noh, Y. S. Hah,R. Nilufar, J. Han, J. H. Bong, S.S. Kang, G. J. Cho, and W. S. Choi, Acetoacetate protects neuronal cells from oxidative glutamate toxicity, J Neurosci Res 83(4), 702-709 (2006).
19. M. A. Puchowicz, D. S. Emancipator, K. Xu, D. L. Magness, O. I. Ndubuizu, W. D. Lust, and J. C. Lamanna, Adaptation to chronic hypoxia during diet-induced ketosis, Adv Exp Med Biol 566 51-57 (2005).
20. M. A. Puchowicz, Emancipator D.S., K. Xu, and J. C. LaManna, Diet induced ketosis reduces lactate levels in acute hypoxic rat brain, FASEB 845.5 (2004).
21. R. C. Crumrine and J. C. LaManna, Regional cerebral metabolites, blood flow, plasma volume, and mean transit time in total cerebral ischemia in the rat, J Cereb Blood Flow Metab 11(2), 272-282 (1991).
22. J. Kim, G. M. Saidel, and M. E. Cabrera, Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control, Ann Biomed Eng 35(1), 69-90 (2007).