MAldi imaging mass spectrometry for direct tissue analysis

Methods in Molecular Biology

Volumn 931, Issue , 2012, Pages 537-546

  Meding, Stephan ^a   Walch, Axel ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Imaging mass spectrometry; In situ proteomics; MALDI Imaging; Morphology based tissue analysis; Tissue proteomics

Indexed keywords

LIPID; PEPTIDE; PROTEIN;

ARTICLE; HISTOLOGY; LIPID ANALYSIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MORPHOLOGY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; TISSUE FIXATION;

EID: 84934434635     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-56-4_29     Document Type: Article

References (22)

1. Heeren RMA et al (2009) Imaging mass spectrometry: hype or hope? J Am Soc Mass Spectrom 20:1006-1014
2. Schwamborn K, CaprioliRM (2010) MALDI imaging mass spectrometry-painting molecular pictures. Mol Oncol 4:529-538
3. Seeley EH, CaprioliRM (2011) MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives. Trends Biotechnol 29:136-143
4. Balluff B et al (2011) MALDI imaging mass spectrometry for direct tissue analysis: technologicaladvancements and recent applications. Histochem Cell Biol 136:227-244
5. Amstalden van Hove ER et al (2010) Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models. Cancer Res 70:9012-9021
6. Burnum KE et al (2009) Spatialand temporalalterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J Lipid Res 50:2290-2298
7. Marko-Varga G et al (2011) Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging. J Proteomics 74:982-992
8. Prideaux B et al (2011) High-sensitivity MALDI-MRM-MS imaging of moxifl oxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions. Anal Chem 83:2112-2118
9. Djidja MC et al (2009) MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections. J Proteome Res 8:4876-4884
10. Groseclose MR et al (2008) High-throughput proteomic analysis offormalin-fixed paraffinembedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics 8: 3715-3724
11. Gustafsson JO et al (2010) Citric acid antigen retrieval (CAAR) for tryptic peptide imaging directly on archived formalin-fixed paraffinembedded tissue. J Proteome Res 9: 4315-4328
12. Lemaire R et al (2007) Direct analysis and MALDI imaging offormalin-fixed, paraffinembedded tissue sections. J Proteome Res 6: 1295-1305
13. Stauber J et al (2010) On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry. J Am Soc Mass Spectrom 21:338-347
14. Balluff B et al (2010) Classification of HER2/ neu status in gastric cancer using a breastcancer derived proteome classifier. J Proteome Res 9:6317-6322
15. Lagarrigue M et al (2010) Revisiting rat spermatogenesis with MALDI imaging at 20 i m resolution. Mol Cell Proteomics 10:M110 005991
16. Meistermann H et al (2006) Biomarker discovery by imaging mass spectrometry: transthyretin is a biomarker for gentamicininduced nephrotoxicity in rat. Mol Cell Proteomics 5:1876-1886
17. Rauser S et al (2010) Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry. J Proteome Res 9:1854-1863
18. Yanagisawa K et al (2003) Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet 362:433-439
19. Franck J et al (2010) MALDI mass spectrometry imaging of proteins exceeding 30,000 daltons. Med SciMonit 16: BR293-BR299
20. Deininger SO et al (2008) MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers. J Proteome Res 7:5230-5236
21. Rauser S et al (2010) Approaching MALDI molecular imaging for clinical proteomic research: current state and fields of application. Expert Rev Proteomics 7:927-941
22. Ergin B et al (2010) Proteomic analysis of PAXgene-fixed tissues. J Proteome Res 9: 5188-5196