RAD18 signals DNA polymerase IOTA to stalled replication forks in cells entering S-phase with DNA damage

Advances in Experimental Medicine and Biology

Volumn 614, Issue , 2008, Pages 137-143

  Kakar, Shelly ^a   Watson, Nicholas B ^a   McGregor, W Glenn ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DNA POLYMERASE; LIGANDIN; RAD18 PROTEIN;

CELL CYCLE S PHASE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; ULTRAVIOLET IRRADIATION;

EUKARYOTA;

EID: 84934434583     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-74911-2_16     Document Type: Conference Paper

References (8)

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3. Prakash, S.& Prakash, L. TranslesionDNAsynthesis in eukaryotes: a one-or two-polymerase affair. Genes Dev. 16, 1872-1883 (2002).
4. Watson, N.B., Mukhopadhyay, S. & McGregor, W.G. Translesion DNA replication proteins as molecular targets for cancer prevention. Cancer Lett. 241, 13-22 (2006).
5. Krude, T. Mimosine arrests proliferating human cells before onset ofDNA replication in a dose-dependent manner. Exp. Cell Res. 247, 148-159 (1999).
6. Mukhopadhyay, S., Clark, D.R., Watson, N.B., Zacharias, W. & McGregor, W.G. REV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide. Nucleic Acids Res. 32, 5820-5826 (2004).
7. Tissier, A. et al. Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REV1 protein. DNA Repair (Amst) 3, 1503-1514 (2004).
8. Bi, X., et al. RAD18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol. Cell Biol. 26, 3527-3540 (2006). 16 RAD18 Signals DNA Polymerase IOTA to Stalled Replication Forks 143