Toxicity of aged gasoline exhaust particles to normal and diseased airway epithelia

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Künzi, Lisa ^a   Krapf, Manuel ^b   Daher, Nancy ^a   Dommen, Josef ^b   Jeannet, Natalie ^e   Schneider, Sarah ^f   Platt, Stephen ^a   Slowik, Jay G ^a   Baumlin, Nathalie ^a   Salathe, Matthias ^b   Prévôt, André S H ^a   Kalberer, Markus ^a   Strähl, Christof ^c   Dümbgen, Lutz ^d   Sioutas, Constantinos ^g   Baltensperger, Urs ^f   Geiser, Marianne ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c University of Southern California   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF BERN   (Switzerland)

^g NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AEROSOL; AIR POLLUTANT; CCL2 PROTEIN, HUMAN; CYTOKINE; EXHAUST GAS; GASOLINE; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PARTICULATE MATTER;

AEROSOL; AIR POLLUTANT; ANALYSIS; BRONCHUS; CELL CULTURE; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; EXHAUST GAS; HUMAN; METABOLISM; PARTICLE SIZE; PARTICULATE MATTER; PHARMACOLOGY; RESPIRATORY MUCOSA; SECRETION (PROCESS); TIME FACTOR;

AEROSOLS; AIR POLLUTANTS; BRONCHI; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; EPITHELIAL CELLS; GASOLINE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; PARTICLE SIZE; PARTICULATE MATTER; RESPIRATORY MUCOSA; TIME FACTORS; VEHICLE EMISSIONS;

EID: 84934301641     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11801     Document Type: Article

References (31)

1. WHO-World Health Organization: Burden of disease from air pollution for 2012. (2014) Available at: http://www.who.int/ mediacentre/news/releases/2014/air-pollution/en/. (Date of access:14/05/2015)
2. Ruckerl, R., Schneider, A., Breitner, S., Cyrys, J. & Peters, A. Health effects of particulate air pollution: A review of epidemiological evidence. Inhal. Toxicol. 23, 555-592 (2011)
3. Liu, L. J. et al. Exposure assessment of particulate matter for susceptible populations in Seattle. Environ. Health Perspect. 111, 909-918 (2003)
4. Goss, C. H., Newsom, S. A., Schildcrout, J. S., Sheppard, L. & Kaufman, J. D. Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis. Am. J. Respir. Crit. Care Med. 169, 816-821 (2004)
5. Bahreini, R. et al. Gasoline emissions dominate over diesel in formation of secondary organic aerosol mass. Geophys. Res. Lett. 39(6), L06805 (2012)
6. Jimenez, J. L. et al. Evolution of organic aerosols in the atmosphere. Science 326, 1525-1529 (2009)
7. Huang, R.-J. et al. High secondary aerosol contribution to particulate pollution during haze events in China. Nature 514(7521), 218-222 (2014)
8. Hayes, P. L. et al. Organic aerosol composition and sources in Pasadena, California, during the 2010 CalNex campaign. J. Geophys. Res. 118, 9233-9257 (2013)
9. Delfino, R. J. et al. Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohort. Epidemiology 21(6), 892-902 (2010)
10. Rager, J. E. et al. A toxicogenomic comparison of primary and photochemically altered air pollutant mixtures. Environ. Health Perspect. 119(11), 1583-1589 (2011)
11. Könzi, L. et al. Responses of lung cells to realistic exposure of primary and aged carbonaceous aerosols. Atmos. Environ. 68, 143-150 (2013)
12. Diaz, E. A. et al. Effects of fresh and aged vehicular exhaust emissions on breathing pattern and cellular responses-pilot single vehicle study. Inhal. Toxicol. 24(5), 288-295 (2012)
13. Van Dingenen, R. et al. A European aerosol phenomenology-1: physical characteristics of particulate matter at kerbside, urban, rural and background sites in Europe. Atmos. Environ. 38, 2561-2577 (2004)
14. Cao, J. J. Pollution status and control strategies of PM2.5 in China. J. Earth Environ. 3, 1030-1036 (2012)
15. Sardar, S. B., Fine, P. M., Mayo, P. R., & Sioutas, C. Size-fractionated measurements of ambient ultrafine particle chemical composition in Los Angeles using the NanoMOUDI. Environ. Sci. Technol. 39(4), 932-944 (2005)
16. Wang, D., Kam, W., Cheung, K., Pakbin, P. & Sioutas, C. Development of a two-stage virtual impactor system for high concentration enrichment of ultrafine, PM2.5, and coarse particulate matter. Aerosol Sci. Technol. 47, 231-238 (2012)
17. EC Air quality Directive 2008/50/EC (2008). Available at: http://ec.europa.eu/environment/air/quality/standards.htm (Date of access:14/05/2015)
18. Mertes, P. et al. A compact and portable deposition chamber to study nanoparticles in air-exposed tissue. J. Aerosol Med. Pulm. Drug Deliv. 26, 228-235 (2013)
19. WHO-World Health Organization: Review of Evidence on Health Aspects of Air Pollution - the REVIHAAP project. Final technical report (2013). Available at: http://www.euro.who.int/-data/assets/pdf-file/0004/193108/REVIHAAP-Final-technical-reportfinal- version.pdf (Date of access:14/05/2015)
20. Lichtveld, K. M. et al. In vitro exposures in diesel exhaust atmospheres: resuspension of PM from filters versus direct deposition of PM from air. Environ. Sci. Technol. 46, 9062-9070 (2012)
21. Volckens, J., Dailey, L., Walters, G. & Devlin, R. B. Direct particle-to-cell deposition of coarse ambient particulate matter increases the production of inflammatory mediators from cultured human airway epithelial cells. Environ. Sci. Technol. 43, 4595-4599 (2009)
22. BéruBé, K. et al. In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. ATLA-Altern. Lab. Anim. 37, 89-141 (2009)
23. Paulsen, D. et al. Secondary organic aerosol formation by irradiation of 1, 3, 5-trimethylbenzene- NOx- H2O in a new reaction chamber for atmospheric chemistry and physics. Environ. Sci. Technol. 39, 2668-2678 (2005)
24. Sullivan, A. P. et al. A method for on-line measurement of water-soluble organic carbon in ambient aerosol particles: results from an urban site. Geophys. Res. Lett. 31, L13105 (2004)
25. Fulcher, M. L., Gabriel, S., Burns, K. A., Yankaskas, J. R. & Randell, S. H. Well-differentiated human airway epithelial cell cultures. Method Mol. Med. 107, 183-206 (2005)
26. Bernacki, S. H. et al. Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced. Am. J. Respir. Cell Mol. Biol. 20, 595-604 (1999)
27. Jeannet, N. et al. Effects of silver and carbon nanoaerosols on normal and cystic fibrosis human bronchial epithelial cells. Nanotoxicology in press doi: 10.3109/17435390.2015.1049233 (2015)
28. DeCarlo, P. F. et al. Field-employable, high-resolution, time-of-flight aerosol mass spectrometer. Anal. Chem. 78, 8281-8289 (2006)
29. Drinovec, L. et al. The "dual-spot" aethalometer: an improved measurement of aerosol black carbon with real-time loading compensation. Atmos. Meas. Tech. 8, 1965-1979 (2015)
30. Ryan, T. P. in Modern regression methods (ed. Ryan, T. P.) John Wiley & Sons (1997)
31. Mann, H. B. & Whitney D. On a test of whether one of two random variables is stochastically larger than the other. Ann. Math. Stat. 18, 50-60 (1947)