메뉴 건너뛰기




Volumn 6, Issue 17, 2015, Pages 14913-14925

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

Author keywords

FTY720; Non small cell lung cancer; PP2A; SET oncoprotein

Indexed keywords

CHAPERONE; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FINGOLIMOD; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN KINASE B; SET PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 84934282103     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3818     Document Type: Article
Times cited : (81)

References (44)
  • 2
    • 84910037773 scopus 로고    scopus 로고
    • Overexpression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) is associated with tumour aggressiveness and poor prognosis in human non-small cell lung cancer
    • Ke Z, He W, Lai Y, Guo X, Chen S, Li S, Wang Y and Wang L. Overexpression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) is associated with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. Oncotarget. 2014; 5:9410.
    • (2014) Oncotarget , vol.5 , pp. 9410
    • Ke, Z.1    He, W.2    Lai, Y.3    Guo, X.4    Chen, S.5    Li, S.6    Wang, Y.7    Wang, L.8
  • 5
    • 84867283479 scopus 로고    scopus 로고
    • Targeting protein-tyrosine phosphatases in breast cancer
    • Aceto N and Bentires-Alj M. Targeting protein-tyrosine phosphatases in breast cancer. Oncotarget. 2012; 3:514-515.
    • (2012) Oncotarget , vol.3 , pp. 514-515
    • Aceto, N.1    Bentires-Alj, M.2
  • 6
    • 84866604619 scopus 로고    scopus 로고
    • Phosphatases: the new brakes for cancer development?
    • Zhang Q and Claret FX. Phosphatases: the new brakes for cancer development? Enzyme Res. 2012; 2012:659649.
    • (2012) Enzyme Res , vol.2012
    • Zhang, Q.1    Claret, F.X.2
  • 7
    • 84876990097 scopus 로고    scopus 로고
    • Protein phosphatase 2A: a target for anticancer therapy
    • Perrotti D and Neviani P. Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol. 2013; 14:e229-238.
    • (2013) Lancet Oncol , vol.14 , pp. e229-e238
    • Perrotti, D.1    Neviani, P.2
  • 10
    • 80755153598 scopus 로고    scopus 로고
    • Low expression of PP2A regulatory subunit B55a is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients
    • Ruvolo PP, Qui Y, Coombes KR, Zhang N, Ruvolo VR, Borthakur G, Konopleva M, Andreeff M and Kornblau SM. Low expression of PP2A regulatory subunit B55a is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients. Leukemia. 2011; 25:1711-1717.
    • (2011) Leukemia , vol.25 , pp. 1711-1717
    • Ruvolo, P.P.1    Qui, Y.2    Coombes, K.R.3    Zhang, N.4    Ruvolo, V.R.5    Borthakur, G.6    Konopleva, M.7    Andreeff, M.8    Kornblau, S.M.9
  • 11
    • 38349190654 scopus 로고    scopus 로고
    • Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
    • Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY and Chiang CW. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem. 2008; 283:1882-1892.
    • (2008) J Biol Chem , vol.283 , pp. 1882-1892
    • Kuo, Y.C.1    Huang, K.Y.2    Yang, C.H.3    Yang, Y.S.4    Lee, W.Y.5    Chiang, C.W.6
  • 12
    • 27744512550 scopus 로고    scopus 로고
    • Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
    • Van Kanegan MJ, Adams DG, Wadzinski BE and Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem. 2005; 280:36029-36036.
    • (2005) J Biol Chem , vol.280 , pp. 36029-36036
    • Van Kanegan, M.J.1    Adams, D.G.2    Wadzinski, B.E.3    Strack, S.4
  • 13
    • 33644524383 scopus 로고    scopus 로고
    • B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK
    • Letourneux C, Rocher G and Porteu F. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. Embo J. 2006; 25:727-738.
    • (2006) Embo J , vol.25 , pp. 727-738
    • Letourneux, C.1    Rocher, G.2    Porteu, F.3
  • 15
    • 43049121301 scopus 로고    scopus 로고
    • A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins
    • Arnold HK and Sears RC. A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev. 2008; 27(2):147-158.
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.2 , pp. 147-158
    • Arnold, H.K.1    Sears, R.C.2
  • 17
    • 0035840446 scopus 로고    scopus 로고
    • Role of serine/threonine protein phosphatase 2A in cancer
    • Schonthal AH. Role of serine/threonine protein phosphatase 2A in cancer. Cancer Lett. 2001; 170(1):1-13.
    • (2001) Cancer Lett , vol.170 , Issue.1 , pp. 1-13
    • Schonthal, A.H.1
  • 18
    • 84907485878 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair
    • Lv P, Wang Y, Ma J, Wang Z, Li JL, Hong CS, Zhuang Z and Zeng YX. Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair. Oncotarget. 2014; 5:7512-7524.
    • (2014) Oncotarget , vol.5 , pp. 7512-7524
    • Lv, P.1    Wang, Y.2    Ma, J.3    Wang, Z.4    Li, J.L.5    Hong, C.S.6    Zhuang, Z.7    Zeng, Y.X.8
  • 19
    • 0029889342 scopus 로고    scopus 로고
    • The myeloid leukemiaassociated protein SET is a potent inhibitor of protein phosphatase 2A
    • Li M, Makkinje A and Damuni Z. The myeloid leukemiaassociated protein SET is a potent inhibitor of protein phosphatase 2A. Journal of Biological Chemistry. 1996; 271:11059-11062.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 11059-11062
    • Li, M.1    Makkinje, A.2    Damuni, Z.3
  • 20
    • 80052259754 scopus 로고    scopus 로고
    • Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET
    • Arnaud L, Chen S, Liu F, Li B, Khatoon S, Grundke-Iqbal I and Iqbal K. Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET. FEBS Lett. 2011; 585:2653-2659.
    • (2011) FEBS Lett , vol.585 , pp. 2653-2659
    • Arnaud, L.1    Chen, S.2    Liu, F.3    Li, B.4    Khatoon, S.5    Grundke-Iqbal, I.6    Iqbal, K.7
  • 21
    • 0037067661 scopus 로고    scopus 로고
    • The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing
    • Cervoni N, Detich N, Seo SB, Chakravarti D and Szyf M. The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. J Biol Chem. 2002; 277:25026-25031.
    • (2002) J Biol Chem , vol.277 , pp. 25026-25031
    • Cervoni, N.1    Detich, N.2    Seo, S.B.3    Chakravarti, D.4    Szyf, M.5
  • 22
    • 1242329866 scopus 로고    scopus 로고
    • Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937
    • Kandilci A, Mientjes E and Grosveld G. Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937. Leukemia. 2004; 18:337-340.
    • (2004) Leukemia , vol.18 , pp. 337-340
    • Kandilci, A.1    Mientjes, E.2    Grosveld, G.3
  • 23
    • 84896733638 scopus 로고    scopus 로고
    • Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation
    • Almeida LO, Garcia CB, Matos-Silva FA, Curti C and Leopoldino AM. Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochem Biophys Res Commun. 2014; 445:196-202.
    • (2014) Biochem Biophys Res Commun , vol.445 , pp. 196-202
    • Almeida, L.O.1    Garcia, C.B.2    Matos-Silva, F.A.3    Curti, C.4    Leopoldino, A.M.5
  • 24
    • 84873840846 scopus 로고    scopus 로고
    • SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells
    • Avet C, Garrel G, Denoyelle C, Laverriere JN, Counis R, Cohen-Tannoudji J and Simon V. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells. J Biol Chem. 2013; 288:2641-2654.
    • (2013) J Biol Chem , vol.288 , pp. 2641-2654
    • Avet, C.1    Garrel, G.2    Denoyelle, C.3    Laverriere, J.N.4    Counis, R.5    Cohen-Tannoudji, J.6    Simon, V.7
  • 25
    • 84921059747 scopus 로고    scopus 로고
    • Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer
    • Cristobal I, Rincon R, Manso R, Carames C, Zazo S, Madoz-Gurpide J, Rojo F and Garcia-Foncillas J. Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer. Clin Cancer Res. 2015; 21:347-356.
    • (2015) Clin Cancer Res , vol.21 , pp. 347-356
    • Cristobal, I.1    Rincon, R.2    Manso, R.3    Carames, C.4    Zazo, S.5    Madoz-Gurpide, J.6    Rojo, F.7    Garcia-Foncillas, J.8
  • 26
    • 84859449771 scopus 로고    scopus 로고
    • Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia
    • Cristóbal I, Garcia-Orti L, Cirauqui C, Cortes-Lavaud X, García-Sánchez MA, Calasanz MJ and Odero MD. Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia. Haematologica. 2012; 97:543-550.
    • (2012) Haematologica , vol.97 , pp. 543-550
    • Cristóbal, I.1    Garcia-Orti, L.2    Cirauqui, C.3    Cortes-Lavaud, X.4    García-Sánchez, M.A.5    Calasanz, M.J.6    Odero, M.D.7
  • 29
    • 84907609978 scopus 로고    scopus 로고
    • SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell
    • Liu H, Gu Y, Yin J, Zheng G, Wang C, Zhang Z, Deng M, Liu J, Jia X and He Z. SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell. Cell Signal. 2014; 26:2710-2720.
    • (2014) Cell Signal , vol.26 , pp. 2710-2720
    • Liu, H.1    Gu, Y.2    Yin, J.3    Zheng, G.4    Wang, C.5    Zhang, Z.6    Deng, M.7    Liu, J.8    Jia, X.9    He, Z.10
  • 30
    • 84896720465 scopus 로고    scopus 로고
    • Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models
    • Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C and Leopoldino AM. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer. 2014; 13:32.
    • (2014) Mol Cancer , vol.13 , pp. 32
    • Sobral, L.M.1    Sousa, L.O.2    Coletta, R.D.3    Cabral, H.4    Greene, L.J.5    Tajara, E.H.6    Gutkind, J.S.7    Curti, C.8    Leopoldino, A.M.9
  • 32
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, Mao H, Chang JS, Galietta A and Uttam A. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer cell. 2005; 8:355-368.
    • (2005) Cancer cell , vol.8 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3    Notari, M.4    Blaser, B.W.5    Liu, S.6    Mao, H.7    Chang, J.S.8    Galietta, A.9    Uttam, A.10
  • 35
    • 79957910918 scopus 로고    scopus 로고
    • Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy
    • Switzer CH, Cheng RY, Vitek TM, Christensen DJ, Wink DA and Vitek MP. Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. Oncogene. 2011; 30:2504-2513.
    • (2011) Oncogene , vol.30 , pp. 2504-2513
    • Switzer, C.H.1    Cheng, R.Y.2    Vitek, T.M.3    Christensen, D.J.4    Wink, D.A.5    Vitek, M.P.6
  • 37
    • 84878431342 scopus 로고    scopus 로고
    • Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
    • Seshacharyulu P, Pandey P, Datta K and Batra SK. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Lett. 2013; 335:9-18.
    • (2013) Cancer Lett , vol.335 , pp. 9-18
    • Seshacharyulu, P.1    Pandey, P.2    Datta, K.3    Batra, S.K.4
  • 39
    • 0035810043 scopus 로고    scopus 로고
    • Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene
    • Ruediger R, Pham HT and Walter G. Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene. 2001; 20:1892-1899.
    • (2001) Oncogene , vol.20 , pp. 1892-1899
    • Ruediger, R.1    Pham, H.T.2    Walter, G.3
  • 40
    • 80052590060 scopus 로고    scopus 로고
    • Human cancer-associated mutations in the Aalpha subunit of protein phosphatase 2A increase lung cancer incidence in Aalpha knock-in and knockout mice
    • Ruediger R, Ruiz J and Walter G. Human cancer-associated mutations in the Aalpha subunit of protein phosphatase 2A increase lung cancer incidence in Aalpha knock-in and knockout mice. Mol Cell Biol. 2011; 31:3832-3844.
    • (2011) Mol Cell Biol , vol.31 , pp. 3832-3844
    • Ruediger, R.1    Ruiz, J.2    Walter, G.3
  • 43
    • 84899000071 scopus 로고    scopus 로고
    • SETting OP449 into the PP2AActivating Drug Family
    • Neviani P and Perrotti D. SETting OP449 into the PP2AActivating Drug Family. Clin Cancer Res. 2014; 20:2026-2028.
    • (2014) Clin Cancer Res , vol.20 , pp. 2026-2028
    • Neviani, P.1    Perrotti, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.