Polypeptide from Chlamys farreri suppresses ultraviolet-B irradiation-induced apoptosis through restoring ER redox homeostasis, scavenging ROS generation, and suppressing the PERK-eIF2a-CHOP pathway in HaCaT cells

Journal of Photochemistry and Photobiology B: Biology

Volumn 151, Issue , 2015, Pages 10-16

  Zhong, Feng ^a   Xie, Jing ^a   Zhang, Di ^a   Han, Yantao ^a   Wang, Chunbo ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum (ER); HaCaT cells; PERK eIF2a CHOP pathway; Ultraviolet B (UVB) irradiation; Unfolded protein response (UPR)

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; CELL ENZYME; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; POLYPEPTIDE; PRK LIKE ENDOPLASMIC RETICULUM KINASE; RADIOPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; DDIT3 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PEPTIDE; PROTEIN KINASE R;

APOPTOSIS; ARTICLE; CELL VIABILITY; CHLAMYS FARRERI; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLOW CYTOMETRY; FREEZE THAWING; HOMEOSTASIS; HUMAN; HUMAN CELL; KERATINOCYTE; MTT ASSAY; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; ULTRAVIOLET B RADIATION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; OXIDATION REDUCTION REACTION; RADIATION RESPONSE; SCALLOP; ULTRAVIOLET RADIATION;

CHLAMYS FARRERI; ERO;

ANIMALS; APOPTOSIS; CELL SURVIVAL; EIF-2 KINASE; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HUMANS; KERATINOCYTES; METABOLIC NETWORKS AND PATHWAYS; OXIDATION-REDUCTION; PECTINIDAE; PEPTIDES; RADIATION-PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP; ULTRAVIOLET RAYS;

EID: 84934278085     PISSN: 10111344     EISSN: 18732682     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2015.06.016     Document Type: Article

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