Prodromal dementia with Lewy bodies

Geriatrics and Gerontology International

Volumn 15, Issue 7, 2015, Pages 817-826

  Fujishiro, Hiroshige ^a   Nakamura, Shinichiro ^b   Sato, Kiyoshi ^c   Iseki, Eizo ^c  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Koshigaya Municipal Hospital   (Japan)

^c JUNTENDO TOKYO KOTO GERIATRIC MEDICAL CENTER   (Japan)

Author keywords

Alzheimer's disease; Lewy body disease; Mild cognitive impairment; Neurocognitive disorder; Parkinson's disease

Indexed keywords

(3 IODOBENZYL)GUANIDINE; DOPAMINE TRANSPORTER;

AUTONOMIC DYSFUNCTION; BRAIN METABOLISM; BRAIN PERFUSION; CLINICAL FEATURE; CONCEPTUAL FRAMEWORK; DIFFUSE LEWY BODY DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; HEART SCINTISCANNING; HUMAN; MENTAL DISEASE; NEUROPSYCHOLOGY; OCCIPITAL LOBE; PARASOMNIA; PARKINSON DISEASE; PARKINSONISM; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PRODROMAL SYMPTOM; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMELLING DISORDER; SYMPTOM ASSESSMENT; COMPLICATION; DEMENTIA; DISEASE COURSE; LEWY BODY DISEASE;

DEMENTIA; DISEASE PROGRESSION; HUMANS; LEWY BODY DISEASE; PRODROMAL SYMPTOMS;

EID: 84933673889     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/ggi.12466     Document Type: Review

References (100)

1. Albert MS, DeKosky ST, Dickson D etal. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroup. Alzheimers Dement 2011; 7: 270-279.
2. McKhann GM, Knopman DS, Chertkow H etal. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 263-269.
3. McKeith IG, Dickson DW, Lowe J etal. Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863-1872.
4. Molano J, Boeve B, Ferman T etal. Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain 2010; 133: 540-556.
5. Jicha GA, Schmitt FA, Abner E etal. Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease. Neurobiol Aging 2010; 31: 1805-1813.
6. Boeve BF. Mild cognitive impairment associated with underlying Alzheimer's disease and versus Lewy body disease. Parkinsonism Relat Disord 2012; 18 (Suppl 1): 41-44.
7. Fujishiro H, Iseki E, Nakamura S etal. Dementia with Lewy bodies: early diagnostic challenges. Psychogeriatrics 2013; 13: 128-138.
8. Chiba Y, Fujishiro H, Iseki E etal. Retrospective survey of prodromal symptoms in dementia with Lewy bodies: comparison with Alzheimer's disease. Dement Geriatr Cogn Disord 2012; 33: 273-281.
9. American Psychiatric Association. Diagnostic and Statistical Manual Disorders, 5th edn. Arlington: American Psychiatric Publishing, 2013.
10. Halliday GH, Holton JL, Revesz T, Dickson DW. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 2011; 122: 187-204.
11. Savica R, Rocca WA, Ahlskog JE. When does Parkinson disease start? Arch Neurol 2010; 67: 798-801.
12. Gaenslen A, Swid I, Liepelt-Scarfone I, Godau J, Berg D. The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease. Mov Disord 2011; 26: 653-658.
13. Ross GW, Abbott RD, Petrovitch H etal. Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 2006; 21: 2062-2067.
14. Tsopelas C, Stewart R, Savva GM etal. Neuropathological correlates of late-life depression in older people. Br J Psychiatry 2011; 198: 109-114.
15. Uchiyama M, Isse K, Tanaka K etal. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 1995; 45: 709-712.
16. Boeve BF, Dickson DW, Olson EJ, Shepard JW, Silber MH, Ferman TJ. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med 2007; 8: 60-64.
17. Abbott RD, Ross GW, Petrovitch H, Tanner CM, White LR. Bowel movement frequency in late-life and incidental Lewy bodies. Mov Disord 2007; 22: 1581-1586.
18. Bloch A, Probst A, Bissig H, Adams H, Tolnay M. Alphasynuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 2006; 32: 284-295.
19. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988; 51: 745-752.
20. Frigerio R, Fujishiro H, Ahn TB etal. Incidental Lewy body disease: do some cases represent preclinical dementia with Lewy bodies? Neurobiol Aging 2011; 32: 857-863.
21. Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 4: 197-211.
22. Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG. Patterns and stages of alpha-synucleiopathy: relevance in a population-based-cohort. Neurology 2008; 70: 1042-1048.
23. Fujishiro H, Ferman TJ, Boeve BF etal. Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases. J Neuropathol Exp Neurol 2008; 67: 649-656.
24. Fujimi K, Sasaki K, Noda K etal. Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study. Brain Pathol 2008; 18: 317-325.
25. Dickson DW. Dementia with Lewy bodies: neuropathology. J Geriatr Psychiatry Neurol 2002; 15: 210-216.
26. Halliday GM, McCann H. The progression of pathology in Parkinson's disease. Ann N Y Acad Sci 2010; 16: 653-661.
27. Ballard C, Ziabreva I, Perry R etal. Differences in neuropathologic characteristics across the Lewy body dementia spectrum. Neurology 2006; 67: 1931-1934.
28. Fujishiro H, Iseki E, Higashi S etal. Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia. Neurosci Lett 2010; 486: 19-23.
29. Gomperts SN, Locascio JJ, Minafra B etal. Brain amyloid and cognition in Lewy body diseases. Mov Disord 2012; 27: 965-973.
30. Gomperts SN. Imaging the role of amyloid in PD dementia and Dementia with Lewy bodies. Curr Neurol Neurosci Rep 2014; 14: 472.
31. Kanemaru K, Kameda N, Yamanouchi H. Decreased CSF amyloid β42 and normal tau levels in dementia with Lewy bodies. Neurology 2000; 54: 1875-1876.
32. Parnetti L, Tiraboschi P, Lanari A etal. Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies. Biol Psychiatry 2008; 64: 850-855.
33. Hall S, Öhrfelt A, Constantinescu R etal. Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders. Arch Neurol 2012; 69: 1445-1452.
34. Greffard S, Verny M, Bonnet AM etal. Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra. Arch Neurol 2006; 63: 584-588.
35. Pletnikova O, West N, Lee MK etal. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol Aging 2005; 26: 1183-1192.
36. Masliah E, Rockenstein E, Veinbergs I etal. Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci U S A 2001; 98: 12245-12250.
37. Lashley T, Holton JL, Gray E etal. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathol 2008; 115: 417-425.
38. Obi K, Akiyama H, Kondo H etal. Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 2008; 210: 409-420.
39. Colom-Cadena M, Gelpi E, Charif S etal. Confluence of α-Synuclein, Tau, and β-Amyloid pathogies in dementia with Lewy bodies. J Neuropathol Exp Neurol 2013; 72: 1203-1212.
40. Braak H, Rüb U, Jansen Steur EN, Del Tredici K, de Vos RA. Cognitive status correlates with neuropathologic stage in Parkinson's disease. Neurology 2005; 64: 1404-1410.
41. Hurtig HI, Trojanowski JQ, Galvin J etal. Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Neurology 2000; 54: 1916-1921.
42. Boeve BF. REM sleep behavior disorder: updated review of the core features, the RBD-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010; 1184: 15-54.
43. Boeve BF, Silber MH, Ferman TJ etal. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med 2013; 14: 754-762.
44. Ferman TJ, Boeve BF, Smith GE etal. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology 2011; 77: 875-882.
45. Dugger BN, Boeve BF, Murray ME etal. Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Mov Disord 2012; 27: 72-78.
46. Schenck CH, Bundile SR, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996; 46: 388-393.
47. Iranzo A, Molinuevo JL, Santamaría J etal. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol 2006; 5: 572-577.
48. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009; 72: 1296-1300.
49. Fantini ML, Farini E, Ortelli P etal. Longitudinal study of cognitive function in idiopathic REM sleep behaviour disorder. Sleep 2011; 34: 619-625.
50. Iranzo A, Valldeoriola F, Lomeña F etal. Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol 2011; 10: 797-805.
51. Postuma RB, Bertrand J-A, Montplaisir J etal. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: a prospective study. Mov Disord 2012; 27: 720-726.
52. Boot BP, Boeve BF, Roberts RO etal. Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study. Ann Neurol 2012; 71: 49-56.
53. Wing YK, Li SX, Mok V etal. Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease. J Neurol Neurosurg Psychiatry 2012; 83: 470-472.
54. Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder: a 16-year update on a previously reported series. Sleep Med 2013; 14: 744-748.
55. Iranzo A, Tolosa E, Gelpi E etal. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol 2013; 12: 443-453.
56. Nomura T, Inoue Y, Kaginuma T, Nakashima K. Clinical significance of REM sleep behavior disorder in Parkinson's disease. Sleep Med 2013; 14: 131-135.
57. Bliwise DL, Trotti LM, Greer SA, Juncos JJ, Rye DB. Phasic muscle activity in sleep and clinical features of Parkinson disease. Ann Neurol 2010; 68: 353-359.
58. Postuma RB, Gagnon JF. Symmetry of Parkinson's disease and REM sleep: one piece of the puzzle. Ann Neurol 2011; 69: 905.
59. Postuma RB, Gagnon JF, Vendette M, Montplaisir JY. Markers of neurodeneration in idiopathic rapid eye movement behavior disorder and Parkinson's disease. Brain 2009; 132: 3298-3307.
60. Williams SS, Williams J, Combrinck M, Christie S, Smith AD, McShane R. Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease. J Neurol Neurosurg Psychiatry 2009; 80: 667-670.
61. Miyamoto T, Miyamoto M, Iwanami M etal. Olfactory dysfunction in idiopathic REM sleep behavior disorder. Sleep Med 2010; 11: 458-461.
62. Postuma RB, Gagnon JF, Vendette M, Desjardins C, Montplaisir JY. Olfaction and color vision identify impending neurodegeneration in rapid eye movement behavior disorder. Ann Neurol 2011; 69: 811-818.
63. Yamanaka Y, Asahina M, Hiraga A, Sakakibara R, Oka H, Hattori T. Over 10 years of isolated autonomic failure preceding dementia and parkinsonism in 2 patients with Lewy body disease. Mov Disord 2007; 22: 595-597.
64. Kaufmann H, Nahm K, Purohit D, Wolfe D. Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 2004; 63: 1093-1095.
65. Kosaka K. Diffuse Lewy body disease in Japan. J Neurol 1990; 237: 197-204.
66. Postuma RB, Gagnon JF, Pelletier A, Montplaisir J. Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies. Mov Disord 2013; 28: 597-604.
67. Iida N, Shibata K, Nagahara Y etal. Case of dementia with Lewy bodies that progressed from schizoaffective disorder. Psychiatry Clin Neurosci 2013; 67: 281-282.
68. Ballard C, Holmes C, McKeith I etal. Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer's disease. Am J Psychiatry 1999; 156: 1039-1045.
69. Poewe W, Wenning GK. Atypical parkinsonism. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C, eds. Neurological Disorders: Course and Treatment. San Diego, IL: Academic Press, 2003; 1081-1098.
70. Takahashi S, Mizukami K, Yasuno F, Asada T. Depression associated with dementia with Lewy bodies (DLB) and the effect of somatotherapy. Psychogeriatrics 2009; 9: 56-61.
71. Onofrj M, Bonanni L, Manzoli L, Thomas A. Cohort study on somatoform disorders in Parkinson disease and dementia with Lewy bodies. Neurology 2010; 74: 1598-1606.
72. Louis ED, Bennett DA. Mild Parkinsonian signs: an overview of an emerging concept. Mov Disord 2007; 22: 1681-1688.
73. Louis ED, Schupf N, Manly J, Marder K, Tang MX, Mayeux R. Association between mild parkinsonian signs and mild cognitive impairment in a community. Neurology 2005; 64: 1157-1161.
74. Bennett DA, Beckett LA, Murray AM etal. Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med 1996; 334: 71-76.
75. Kaye JA, Oken BS, Howieson J, Holm LA, Dennison K. Neurologic evaluation of the optimally healthy oldest old. Arch Neurol 1994; 51: 1205-1211.
76. Haaxma CA, Bloem BR, Borm GF, Horstink MW. Comparison of a timed motor test battery to the Unified Parkinson's Disease Rating Scale-III in Parkinson's disease. Mov Disord 2008; 23: 1707-1717.
77. Postuma RB, Lang AE, Gagnon JF, Pelletier A, Montplaisir JY. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behavior disorder. Brain 2012; 135: 1860-1870.
78. Hughes AJ, Daniel SE, Kilford L etal. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-184.
79. Ferman TJ, Smith GE, Kantarci K etal. Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies. Neurology 2013; 81: 2032-2038.
80. Tiraboschi P, Salmon DP, Hansen LA etal. What best differentiates Lewy body from Alzheimer's disease in early-stage dementia? Brain 2006; 129: 729-735.
81. Hamilton JM, Salmon DP, Galasko D etal. Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies. Neuropsychology 2008; 22: 729-737.
82. Hamilton JM, Landy KM, Salmon DP, Hansen LA, Masliah E, Galasko D. Early visuospatial deficits predict the occurrence of visual hallucinations in autopsy-confirmed dementia with Lewy bodies. Am J Geriatr Psychiatry 2012; 20: 773-781.
83. Yoshita M, Taki J, Yokoyama K etal. Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Neurology 2006; 66: 1850-1854.
84. Sinha N, Firbank M, O'Brien JT. Biomarkers in dementia with Lewy bodies: a review. Int J Geriatr Psychiatry 2012; 27: 443-453.
85. 123I-MIBG Cardiac Scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder. Sleep 2008; 31: 717-723.
86. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Follow-up study of cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Eur J Neurol 2011; 18: 1275-1278.
87. Sakakibara R, Ogata T, Haruta M etal. Amnestic mild cognitive impairment with low myocardial metaiodobenzylguanidine uptake. Am J Neurodegener Dis 2012; 1: 146-151.
88. 123I-MIBG cardiac scintigraphy. J Neurol Sci 2012; 315: 115-119.
89. Fujishiro H, Iseki E, Kasanuki K etal. Glucose hypometabolism in primary visual cortex is commonly associated with clinical features of dementia with Lewy bodies regardless of cognitive conditions. Int J Geriatr Psychiatry 2012; 27: 1138-1146.
90. Orimo S, Uchihara T, Nakamura A etal. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008; 131: 642-650.
91. Fujishiro H, Frigerio R, Burnett M etal. Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease. Mov Disord 2008; 23: 1085-1092.
92. Walker Z, Jaros E, Walker RW etal. Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry 2007; 78: 1176-1181.
93. McKeith I, O'Brien J, Walker Z etal. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol 2007; 6: 305-313.
94. Fearnley JM, Lees AJ. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991; 114: 2283-2301.
95. Ross GW, Petrovitch H, Abbott RD etal. Parkinsonian signs and substantia nigra neuron density in descendents elders without PD. Ann Neurol 2004; 56: 532-539.
96. Siepel FJ, Rongve A, Buter TC etal. (123I)FP-CIT SPECT in suspected dementia with Lewy bodies: a longitudinal case study. BMJ Open 2013; 3: e002642.
97. Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhi DE. Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 2001; 50: 358-365.
98. 18F]-FDG PET scans in patients with idiopathic REM sleep behavior disorder: prodromal dementia with Lewy bodies? Psychogeriatrics 2010; 10: 144-152.
99. Fujishiro H, Iseki E, Kasanuki K etal. A follow up study of non-demented patients with primary visual cortical hypometabolism: prodromal dementia with Lewy bodies. J Neurol Sci 2013; 334: 48-54.
100. Kantarci K, Lowe VJ, Boeve BF etal. Multimodality imaging characteristics of dementia with Lewy bodies. Neurobiol Aging 2012; 33: 2091-2105.