Putative physiological mechanisms underlying tDCS analgesic effects

Frontiers in Human Neuroscience

Volumn , Issue SEP, 2013, Pages

  Knotkova, Helena ^a,b   Nitsche, Michael A ^c   Cruciani, Ricardo A ^a,b  

^a BETH ISRAEL MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Analgesia; Mechanisms; Neuromodulation; Pain; Transcranial direct current stimulation (tDCS)

Indexed keywords

EID: 84933670978     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00628     Document Type: Review

References (47)

1. Antal, A., Brepohl, N., Poreisz, C., Boros, K., Csifcsak, G., and Paulus, W. (2008). Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception. Clin. J. Pain 24, 56-63. doi: 10.1097/ajp.0b013e318157233b
2. Antal, A., Terney, D., Kuhnl, S., and Paulus, W. (2010). Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition. J. Pain Symptom Manage. 39, 890-903. doi: 10.1016/j.jpainsymman.2009.09.023
3. Batsikadze, G., Moliadze, V., Paulus, W., Kuo, M. F., and Nitsche, M. A. (2013). Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans. J. Physiol. 591, 1987-2000. doi: 10.1113/jphysiol.2012.249730
4. Boggio, P. S., Zaghi, S., Lopes, M., and Fregni, F. (2008). Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers. Eur. J. Neurol. 15, 1124-1130. doi: 10.1111/j.1468-1331.2008.02270.x
5. Borckardt, J. J., Romagnuolo, J., Reeves, S. T., Madan, A., Frohman, H., Beam, W., et al. (2011). Feasibility, safety, and effectiveness of transcranial direct current stimulation for decreasing post-ERCP pain: a randomized, sham-controlled, pilot study. Gastrointest. Endosc. 73, 1158-1164. doi: 10.1016/j.gie.2011.01.050
6. Catafu, A. M., Perez, V., Gironell, A., Martin, J. C., Kulisevsky, J., Estorch, M., et al. (2001). SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic stimulation in depressed patients. Psychiatry Res. 106, 151-160. doi: 10.1016/s0925-4927(01)00079-8
7. Chiou, R. J., Lee, H. Y., Chang, C. W., Lin, K. H., and Kuo, C. C. (2012). Epidural motor cortex stimulation suppresses somatosensory evoked potentials in the primary somatosensory cortex of the rat. Brain Res. 1463, 42-50. doi: 10.1016/j.brainres.2012.04.027
8. Choi, J., and Callaway, E. M. (2011). Monosynaptic inputs to ErbB4-expressing inhibitory neurons in mouse primary somatosensory cortex. J. Comp. Neurol. 519, 3402-3414. doi: 10.1002/cne.22680
9. DaSilva, A. F., Granziera, C., Snyder, J., and Hadjikhani, N. (2007). Thickening in the somatosensory cortex of patients with migraine. Neurology 69, 1990-1995. doi: 10.1212/01.wnl.0000291618.32247.2d
10. DaSilva, A. F., Mendonca, M. E., Zaghi, S., Lopes, M., DosSantos, M. F., Spierings, E. L., et al. (2012). tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache 52, 1283-1295. doi: 10.1111/j.1526-4610.2012.02141.x
11. DosSantos, M. F., Love, T. M., Martikainen, I. K., Nascimento, T. D., Fregni, F., Cummiford, C., et al. (2012). Immediate effects of tDCS on the mu-opioid system of a chronic patient. Front. Psychiatry 3:93. doi: 10.3389/fpsyt.2012.00093
12. Fenton, B., Fanning, J., Boggio, P., and Fregni, F. (2008). A pilot efficacy trial of tDCS for the treatment of refractory chronic pelvic pain. Brain Stimul. 1, 260. doi: 10.1016/j.brs.2008.06.044
13. Fenton, B. W., Palmieri, P. A., Boggio, P., Fanning, J., and Fregni, F. (2009). A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain. Brain Stimul. 2, 103-107. doi: 10.1016/j.brs.2008.09.009
14. Fregni, F., Boggio, P. S., Lima, M. C., Ferreira, M. J., Wagner, T., and Rigonatti, S. P. (2006a). A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain 122, 197-209. doi: 10.1016/j.pain.2006.02.023
15. Fregni, F., Gimenes, R., Valle, A. S., Ferreira, M. J., Rocha, R. R., Natalle, L., et al. (2006b). A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum. 54, 3988-3998.
16. Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., and Cohen, L. G. (2010). Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 66, 198-204. doi: 10.1016/j.neuron.2010.03.035
17. Garcia-Larrea, L., and Peyron, R. (2007). Motor cortex stimulation for neuropathic pain: from phenomenology to mechanisms. Neuroimage 37, S71-S79. doi: 10.1016/j.neuroimage.2007.05.062
18. Garcia-Larrea, L., Peyron, R., Mentens, P., Gregoire, M. C., Lavenne, F., Le Bars, D., et al. (1999). Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. Pain 259-273. doi: 10.1016/s0304-3959(99)00114-1
19. Hsieh, J. C., Belfrage, M., Stone-Elander, M., Hansson, P., and Ingvar, M. (1995). Central representation of chronic ongoing neuropathic pain studies by positron emission tomography. Pain 63, 225-236. doi: 10.1016/0304-3959(95)00048-w
20. Knotkova, H., Homel, P., and Cruciani, R. A. (2009). Cathodal tDCS over the somatosensory cortex relieved chronic neuropathic pain in a patient with complex regional pain syndrome (CRPS/RSD). Case Report. J. Pain Manag. 2, 365-368. doi: 10.1016/j.jpain.2009.01.164
21. Knotkova, H., Leuschner, Z., Soto, E., Greenberg, A., and Cruciani, R. A. (2013). Evaluation of outcomes from Transcranial Direct Current Stimulation (tDCS) for the treatment of chronic pain. J. Pain 14, S64.
22. Kuhnl, S., Terney, D., Paulus, W., and Antal, A. (2008). The effect of daily sessions of anodal tDCS on chronic pain. Brain Stimul. 1, 281. doi: 10.1016/j.brs.2008.06.249
23. Kuo, M. F., Grosch, J., Fregni, F., Paulus, W., and Nitsche, M. A. (2007). Focusing effect of acetylcholine on neuroplasticity in the human motor cortex. J. Neurosci. 27, 14442-14447. doi: 10.1523/jneurosci.4104-07.2007
24. Monte-Silva, K., Kuo, M. F., Hessenthaler, S., Fresnoza, S., Liebetanz, D., Paulus, W., et al. (2013). Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation. Brain Stimul. 6, 424-432. doi: 10.1016/j.brs.2012.04.011
25. Moisset, X., and Bouhassira, D. (2007). Brain imaging of neuropathic pain. Neuroimage 37(Suppl. 1), S80-S88. doi: 10.1016/j.neuroimage.2007.03.054
26. Mori, F., Codeca, C., Kusayanagi, H., Monteleone, F., Buttari, F., Fiore, S., et al. (2010). Effects of anodal transcranial direct current stimulation on chronic neuropathic pain in patients with multiple sclerosis. J. Pain 11, 436-442. doi: 10.1016/j.jpain.2009.08.011
27. Mottaghy, F. M., Krause, B. J., Kemna, L. J., Topper, R., Tellmann, L., and Beu, M. (2000). Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation. Neurosci. Lett. 280, 167-170. doi: 10.1016/s0304-3940(00)00798-9
28. Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., et al. (2008). Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 1, 206-223. doi: 10.1016/j.brs.2008.06.004
29. Nitsche, M. A., Doemkes, S., Karakose, T., Antal, A., Liebetanz, D., Lang, N., et al. (2007). Shaping the effects of transcranial direct current stimulation of the human motor cortex. J. Neurophysiol. 97, 3109-3117. doi: 10.1152/jn.01312.2006
30. Nitsche, M. A., Fricke, K., Henschke, U., Schlitterlau, A., Liebetanz, D., Lang, N., et al. (2003). Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J. Physiol. 553, 293-301. doi: 10.1113/jphysiol.2003.049916
31. Nitsche, M. A., Grundey, J., Liebetanz, D., Lang, N., Tergau, F., and Paulus, W. (2004a). Catecholaminergic consolidation of motor cortical neuroplasticity in humans. Cereb. Cortex 14, 1240-1245. doi: 10.1093/cercor/bhh085
32. Nitsche, M. A., Jaussi, W., Liebetanz, D., Lang, N., Tergau, F., and Paulus, W. (2004b). Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology 29, 1573-1578. doi: 10.1038/sj.npp.1300517
33. Nitsche, M. A., Kuo, M. F., Karrasch, R., Wächter, B., Liebetanz, D., and Paulus, W. (2009). Serotonin affects transcranial direct current-induced neuroplasticity in humans. Biol. Psychiatry 66, 503-508. doi: 10.1055/s-0029-1238466
34. Nitsche, M. A., Lampe, C., Antal, A., Liebetanz, D., Lang, N., Tergau, F., et al. (2006). Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex. Eur. J. Neurosci. 23, 1651-1657. doi: 10.1111/j.1460-9568.2006.04676.x
35. Nitsche, M. A., Liebetanz, D., Antal, A., Lang, N., Tergau, F., and Paulus, W. (2003). Modulation of cortical excitability by weak direct current stimulation-technical, safety and functional aspects. Suppl. Clin. Neurophysiol. 56, 255-276. doi: 10.1016/S1567-424X(09)70230-2
36. Nitsche, M. A., Liebetanz, D., Schlitterlau, A., Henschke, U., Fricke, K., Frommann, K., et al. (2004c). GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans. Eur. J. Neurosci. 19, 2720-2726. doi: 10.1111/j.0953-816X.2004.03398.x
37. Nitsche, M. A., and Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J. Physiol. 527, 633-639. doi: 10.1111/j.1469-7793.2000.t01-1-00633.x
38. Nitsche, M. A., and Paulus, W. (2001). Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 57, 1899-1901. doi: 10.1212/wnl.57.10.1899
39. O'Connell, N. E., Wand, B. M., Marston, L., Spencer, S., and Desouza, L. H. (2011). Non-invasive brain stimulation techniques for chronic pain. A report of a Cochrane systematic review and meta-analysis. Eur. J. Phys. Rehabil. Med. 47, 309-326.
40. Pagano, R. L., Fonoff, E. T., Dale, C. S., Ballester, G., Teixeira, M. J., and Britto, L. R. (2012). Motor cortex stimulation inhibits thalamic sensory neurons and enhances activity of PAG neurons: possible pathways for antinociception. Pain 153, 2359-2369. doi: 10.1016/j.pain.2012.08.002
41. Peyron, R., Garcia-Larrea, L., Deiber, M. P., Cinotti, L., Convers, P., Sindou, M., et al. (1995). Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study. Pain 62, 275-286. doi: 10.1016/0304-3959(94)00211-v
42. Polania, R., Paulus, W., and Nitsche, M. A. (2011). Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation. Hum. Brain Mapp. 33, 2499-2508. doi: 10.1002/hbm.21380
43. Riberto, M., Marcon Alfieri, F., Monteiro de Benedetto Pacheco, K., Dini Leite, V., Nemoto Kaihami, H., Fregni, F., et al. (2011). Efficacy of transcranial direct current stimulation coupled with a multidisciplinary rehabilitation program for the treatment of fibromyalgia. Open Rheumatol. J. 5, 45-50. doi: 10.2174/1874312901105010045
44. Stefani, L. C., Torres, I. L., de Souza, I. C., Rozisky, J. R., Fregni, F., and Caumo, W. (2012). BDNF as an effect modifier for gender effects on pain thresholds in healthy subjects. Neurosci. Lett. 514, 62-66. doi: 10.1016/j.neulet.2012.02.057
45. Terney, D., Bergmann, I., Poreisz, C., Chaieb, L., Boros, K., Nitsche, M. A., et al. (2008). Pergolide increases the efficacy of cathodal direct current stimulation to reduce the amplitude of laser-evoked potentials in humans. J. Pain Symptom Manage. 36, 79-91. doi: 10.1016/j.jpainsymman.2007.08.014
46. Valle, A., Roizenblatt, S., Botte, S., Zaghi, S., Riberto, M., Tufik, S., et al. (2009). Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: results of a randomized, sham-controlled longitudinal clinical trial. J. Pain Manag. 2, 353-361.
47. Zaghi, S., Heine, N., and Fregni, F. (2009). Brain stimulation for the treatment of pain: a review of costs, clinical effects, and mechanisms of treatment for three different central neuromodulatory approaches. J. Pain Manag. 2, 339-352.