Phosphatidylinositol Induces Caspase-Independent Apoptosis of Malignant Pleural Mesothelioma Cells by Accumulating AIF in the Nucleus

Cellular Physiology and Biochemistry

Volumn 36, Issue 3, 2015, Pages 1037-1048

  Kanemura, Shingo ^a   Tsuchiya, Ayako ^a   Kanno, Takeshi ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

AIF; Bid; Caspase independent apoptosis; Malignant pleural mesothelioma; Phosphatidylinositol

Indexed keywords

1,2 DIOLEOYL SN GLYCERO 3 PHOSPHO(1' MYOINOSITOL); 1,2 DIPALMITOYL SN GLYCERO 3 PHOSPHO(1' MYO INOSITOL); APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 4; CASPASE 8; CASPASE 9; PHOSPHATIDYLINOSITOL; UNCLASSIFIED DRUG; AIFM1 PROTEIN, HUMAN; BID PROTEIN, HUMAN; CASPASE; PROTEIN BID; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MESOTHELIOMA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; AGONISTS; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; PLEURA; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUNEL ASSAY;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHATIDYLINOSITOLS; PLEURA; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84933566354     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430277     Document Type: Article

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