Steady-state tilt has no effect on cerebrovascular CO2 reactivity in anterior and posterior cerebral circulations

Experimental Physiology

Volumn 100, Issue 7, 2015, Pages 839-851

  Tymko, Michael M ^a,b   Skow, Rachel J ^b,c   Mackay, Christina M ^b,c   Day, Trevor A ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MOUNT ROYAL UNIVERSITY   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE;

ADULT; ANTERIOR CEREBRAL ARTERY; ARTICLE; AUTOREGULATION; BLOOD FLOW VELOCITY; BODY POSITION; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN VASCULAR RESISTANCE; CEREBRAL AUTOREGULATION; CEREBROVASCULAR CARBON DIOXIDE REACTIVITY; FEMALE; HEAD TILTING; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; POSTERIOR CEREBRAL ARTERY; QUANTITATIVE ANALYSIS; REBREATHING; STEADY STATE; BLOOD PRESSURE; BODY POSTURE; BRAIN; HEART RATE; METABOLISM; MIDDLE CEREBRAL ARTERY; PHYSIOLOGY; VASCULARIZATION;

ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE CEREBRAL ARTERY; POSTURE;

EID: 84933526647     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/EP085084     Document Type: Article

References (54)

1. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 296, R1473-1495.
2. Ainslie PN & Hoiland RL (2014). Transcranial Doppler ultrasound: valid, invalid, or both? J Appl Physiol 117, 1081-1083.
3. Battisti-Charbonney A, Fisher JA & Duffin J (2011). Respiratory, cerebrovascular and cardiovascular responses to isocapnic hypoxia. Respir Physiol Neurobiol 179, 259-268.
4. Bellapart J & Fraser JF (2009). Transcranial Doppler assessment of cerebral autoregulation. Ultrasound Med Biol 35, 883-893.
5. Bundgaard-Nielsen M, Sørensen H, Dalsgaard M, Rasmussen P & Secher NH (2009). Relationship between stroke volume, cardiac output and filling of the heart during tilt. Acta Anaesthesiol Scand 53, 1324-1328.
6. Cassaglia PA, Griffiths RI & Walker AM (2009). Cerebral sympathetic nerve activity has a major regulatory role in the cerebral circulation in REM sleep. J Appl Physiol 106, 1050-1056.
7. Claassen JA, Levine BD & Zhang R (2009). Dynamic cerebral autoregulation during repeated squat-stand maneuvers. J Appl Physiol 106, 153-160.
8. Coverdale NS, Gati JS, Opalevych O, Perrotta A & Shoemaker JK (2014). Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia. J Appl Physiol 117, 1090-1096.
9. Dineen NE, Brodie FG, Robinson TG & Panerai RB (2010). Continuous estimates of dynamic cerebral autoregulation during transient hypocapnia and hypercapnia. J Appl Physiol 108, 604-613.
10. Duffin J (2011). Measuring the respiratory chemoreflexes in humans. Respir Physiol Neurobiol 177, 71-79.
11. 2 responsiveness with changes in arterial PCO2. Am J Physiol Regul Integr Comp Physiol 287, R627-R632.
12. Edwards MR, Shoemaker JK & Hughson RL (2002). Dynamic modulation of cerebrovascular resistance as an index of autoregulation under tilt and controlled PetCO2. Am J Physiol Regul Integr Comp Physiol 283, R653-R662.
13. Fierstra J, Sobczyk O, Battisti-Charbonney A, Mandell DM, Poublanc J, Crawley AP, Mikulis DJ, Duffin J & Fisher JA (2013). Measuring cerebrovascular reactivity: what stimulus to use? J Physiol 591, 5809-5821.
14. Gelinas JC, Marsden KR, Tzeng YC, Smirl JD, Willie CK, Lewis NC, Binsted G, Bailey DM, Bakker A, Day TA & Ainslie PN (2012). Influence of posture on the regulation of cerebral perfusion. Aviat Space Environ Med 83, 751-757.
15. Haykowsky MJ, Eves ND, Warburton DER & Findlay MJ (2003). Resistance exercise, the Valsalva maneuver, and cerebrovascular transmural pressure. Med Sci Sports Exerc 35, 65-68.
16. Hetzel A, Braune S, Guschlbauer B, Dohms K, Prasse A & Lücking CH (1999). Multimodality monitoring during passive tilt and Valsalva maneuver under hypercapnia. J Neuroimaging 9, 108-112.
17. Hoiland R, Ainslie PN, Wilfong K, Smith K, Willie CK, Bain A, Foster G, Monteleone B & Day TA (2015). Indomethacin-induced impairment of regional cerebrovascular reactivity: implications for respiratory control. J Physiol 593, 1291-1306.
18. Hughes JM & Bund SJ (2002). Arterial myogenic properties of the spontaneously hypertensive rat. Exp Physiol 87, 527-534.
19. Jordan J, Shannon JR, Diedrich A, Black B, Costa F, Robertson D & Biaggioni I (2000). Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension 36, 383-388.
20. Kety SS & Schmidt CF (1948). The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 27, 484-492.
21. Kuo TB, Chern CM, Sheng WY, Wong WJ & Hu HH (1998). Frequency domain analysis of cerebral blood flow velocity and its correlation with arterial blood pressure. J Cereb Blood Flow Metab 18, 311-318.
22. Lassen NA (1959). Cerebral blood flow and oxygen consumption in man. Physiol Rev 39, 183-238.
23. Lewis NC, Messinger L, Monteleone B & Ainslie PN (2014). Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity. J Appl Physiol 116, 1189-1196.
24. Lucas SJ, Lewis NC, Sikken EL, Thomas KN & Ainslie PN (2013). Slow breathing as a means to improve orthostatic tolerance: a randomized sham-controlled trial. J Appl Physiol 115, 202-211.
25. Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S & Ainslie PN (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55, 698-705.
26. Mahony PJ, Panerai RB, Deverson ST, Hayes PD & Evans DH (2000). Assessment of the thigh cuff technique for measurement of dynamic cerebral autoregulation. Stroke 31, 476-480.
27. Murrell CJ, Cotter JD, George K, Shave R, Wilson L, Thomas K, Williams MJ & Ainslie PN (2011). Syncope is unrelated to supine and postural hypotension following prolonged exercise. Eur J Appl Physiol 111, 469-476.
28. Ogoh S, Brothers M, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A & Raven PB (2005). The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J Physiol 592, 697-704.
29. Panerai RB (1998). Assessment of cerebral pressure autoregulation in humans - a review of measurement methods. Physiol Meas 19, 305-338.
30. Peebles KC, Ball OG, MacRae BA, Horsman HM & Tzeng YC (2012). Sympathetic regulation of the human cerebrovascular response to carbon dioxide. J Appl Physiol 113, 700-706.
31. Perry BG, Lucas SJ, Thomas KN, Cochrane DJ & Mundel T (2014). The effect of hypercapnia on static cerebral autoregulation. Physiol Rep 2, 10.14814/phy2.12059.
32. Perry BG, Schlader ZJ, Raman A, Cochrane DJ, Lucas SJ & Mündel T (2013). Middle cerebral artery blood flow velocity in response to lower body positive pressure. Clin Physiol Funct Imaging 33, 483-488.
33. Piechnik SK, Czosnyka M, Richards HK, Whitfield PC & Pickard JD (2001). Cerebral venous blood outflow: a theoretical model based on laboratory simulation. Neurosurgery 49, 1214-22.
34. 2 in humans. J Appl Physiol 81, 1084-1095.
35. Rickards CA, Cohen KD, Bergeron LL, Burton BL, Khatri PJ, Lee CT, Ryan KL, Cooke WH, Doerr DF & Convertino VA (2007). Cerebral blood flow response and its association with symptoms during orthostatic hypotension. Aviat Space Environ Med 78, 653-658.
36. Sato K, Fisher JP, Seifert T, Overgaard M, Secher NH & Ogoh S (2012a). Blood flow in internal carotid and vertebral arteries during orthostatic stress. Exp Physiol 97, 1272-1280.
37. 2 in human internal and external carotid and vertebral arteries. J Physiol 590, 3277-3290.
38. Serrador JM, Picot PA, Rutt BK, Shoemaker JK & Bondar RL (2000). MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31, 1672-1678.
39. 2 reactivity in anterior and posterior cerebral circulations. Respir Physiol Neurobiol 189, 76-86.
40. Skow RJ, Tymko MM, MacKay CM, Steinback CD & Day TA (2014). The effects of head-up and head-down tilt on central respiratory chemoreflex loop gain tested by hyperoxic rebreathing. Prog Brain Res 212, 149-172.
41. Smirl JD, Tzeng YC, Monteleone BJ & Ainslie PN (2014). Influence of cerebrovascular resistance on the dynamic relationship between blood pressure and cerebral blood flow in humans. J Appl Physiol 116, 1614-1622.
42. Smith KJ, MacLeod D, Willie CK, Lewis NC, Hoiland RL, Ikeda K, Tymko MM, Donelly J, Day TA, MacLeod N, Lucas SJ & Ainslie PN (2014). Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery. J Physiol 592, 5507-5527.
43. Steinback CD & Poulin MJ (2008). Cardiovascular and cerebrovascular responses to acute isocapnic and poikilocapnic hypoxia in humans. J Appl Physiol 104, 482-489.
44. Tiecks FP, Lam AM, Aaslid R & Newell DW (1995). Comparison of static and dynamic cerebral autoregulation measurements. Stroke 26, 1014-1019.
45. Tzeng YC, Ainslie PN, Cooke WH, Peebles KC, Willie CK, MacRae BA, Smirl JD, Horsman HM & Rickards CA (2012). Assessment of cerebral autoregulation: the quandary of quantification. Am J Physiol Heart Circ Physiol 303, H658-H671.
46. Tzeng YC, MacRae BA, Ainslie PN & Chan GS (2014). Fundamental relationships between blood pressure and cerebral blood flow in humans. J Appl Physiol 117, 1037-1048.
47. Tzeng YC, Willie CK, Atkinson G, Lucas SJ, Wong A & Ainslie PN (2010). Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension 56, 268-273.
48. Verbree J, Bronzwaer AS, Ghariq E, Versluis MJ, Daemen MJ, vanBuchem MA, Dahan A, vanLieshout JJ & vanOsch MJ (2014). Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra-high-field MRI. J Appl Physiol 117, 1084-1089.
49. Wehrwein EA & Joyner MJ (2013). Regulation of blood pressure by the arterial baroreflex and autonomic nervous system. Handb Clin Neurol 117, 89-102.
50. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ, Smirl JD, Day TA, Lucas SJ, Eller LK & Ainslie PN (2011). Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 196, 221-237.
51. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA & Ainslie PN (2012). Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590, 3261-3275.
52. Willie CK, Tzeng YC, Fisher JA & Ainslie PN (2014). Integrative regulation of human brain blood flow. J Physiol 592, 841-859.
53. Wolff HG, Lennox WG & Allen M (1930). Cerebral circulation: Xii. The effect on pial vessels of variations in the oxygen and carbon dioxide content of the blood. Archives of Neurology & Psychiatry 23, 1097-1120.
54. Yang J, Clark JW Jr, Bryan RM & Robertson C (2003). The myogenic response in isolated rat cerebrovascular arteries: smooth muscle cell model. Med Eng Phys 25, 691-709.