Indomethacin-induced impairment of regional cerebrovascular reactivity: Implications for respiratory control

Journal of Physiology

Volumn 593, Issue 5, 2015, Pages 1291-1306

  Hoiland, Ryan L ^a   Ainslie, Philip N ^a   Wildfong, Kevin W ^a   Smith, Kurt J ^a   Bain, Anthony R ^a   Willie, Chris K ^a   Foster, Glen ^a   Monteleone, Brad ^a   Day, Trevor A ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MOUNT ROYAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; INDOMETACIN; OXYGEN; CARDIOVASCULAR AGENT;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; CHEMORECEPTOR REFLEX; END TIDAL CARBON DIOXIDE TENSION; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPEROXIA; HYPOXIA; LUNG GAS EXCHANGE; LUNG VENTILATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATION CONTROL; STEADY STATE; VOLUNTEER; BLOOD; BRAIN CIRCULATION; BRAIN CORTEX; BREATHING; DRUG EFFECTS; PHYSIOLOGY; REFLEX; VASCULARIZATION;

ADULT; CARBON DIOXIDE; CARDIOVASCULAR AGENTS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; INDOMETHACIN; MALE; OXYGEN; REFLEX; RESPIRATION;

EID: 84923582009     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.284521     Document Type: Article

References (58)

1. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 296, R1473-R1495.
2. Ainslie PN & Hoiland RL (2014). Transcranial Doppler ultrasound: valid, invalid, or both? J Appl Physiol 117, 1081-1083.
3. Ainslie PN, Shaw AD, Smith KJ, Willie CK, Ikeda K, Graham J & Macleod DB (2014). Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia. Clin Sci (Lond) 126, 661-670.
4. Black MA, Cable NT, Thijssen DHJ & Green DJ (2008). Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51, 203-210.
5. Burgess K, Lucas S, Sheperd K, Dawson A, Swart M, Thomas K, Lucas R, Donnelly P, Peebles K, Basnyat R & Ainslie P (2014a). Influence of cerebral blood flow on central sleep apnea at high altitude. Sleep 37, 1679-1687.
6. Burgess KR, Fan J, Peebles K, Thomas K, Lucas S, Lucas R, Dawson A, Swart M, Shepherd K & Ainslie P (2014b). Exacerbation of obstructive sleep apnea by oral indomethacin. Chest 137, 707-710.
7. Chapman RW, Santiago TV & Edelman NH (1979). Effects of graded reduction of brain blood flow on chemical control of breathing. J Appl Physiol 47, 1289-1294.
8. Coverdale NS, Gati JS, Opalevych O, Perrotta A & Shoemaker JK (2014). Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia. J Appl Physiol 117, 1090-1096.
9. 2 below eupnoea as a determinant of ventilatory stability in sleep. J Physiol 560, 1-11.
10. Dempsey JA & Strakud JB (1986). Sleep-induced apnoeic threshold and its consequences. Am Rev Respir Dis 133, 1163-1170.
11. Dempsey JA, Veasey SC, Morgan BJ & O'Donnell CP (2010). Pathophysiology of sleep apnea. Physiol Rev 90, 47-112.
12. Evans D (1985). On the measurement of the mean velocity of blood flow over the cardiac cycle using Doppler ultrasound. Ultrasound Med Biol 11, 735-741.
13. 2 and breathing stability: the influence of PCO2 gradients. Am J Physiol Regul Integr Comp Physiol 298, R1648-R1658.
14. Fan JL, Burgess KR, Thomas KN, Peebles KC, Lucas SJE, Lucas RAI, Cotter JD & Ainslie PN (2010b). Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia. Eur J Appl Physiol 111, 601-610.
15. Fencl V (1986). Acid-base balance in cerebral fluids. Compr Physiol 115-140, doi: 10.1002/cphy.cp030204.
16. Fierstra J, Sobczyk O, Battisti-Charbonney A, Mandell DM, Poublanc J, Crawley AP, Mikulis DJ, Duffin J & Fisher JA (2013). Measuring cerebrovascular reactivity: what stimulus to use? J Physiol 591, 5809-5821.
17. Foster GE, Ainslie PN, Stembridge M, Day TA, Bakker A, Lucas SJE, Lewis NCS, MacLeod DB & Lovering AT (2014). Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas. J Physiol 592, 1397-1409.
18. Giller C (2003). The emperor has no clothes: velocity, flow, and the use of TCD. J Neuroimaging 13, 97-98.
19. Green RS, Leffler CW, Busija DW, Fletcher a M & Beasley DG (1987). Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet. Pediatr Res 21, 534-537.
20. Guyenet PG, Stornetta RL & Bayliss DA (2010). Central respiratory chemoreception. J Comp Neurol 518, 3883-3906.
21. Honda Y, Kimura H & Tanaka M (1997). Role of carotid body activity responsible for hypoxic ventilatory decline in awake humans. J Appl Physiol 82, 371.
22. Javaheri S & Dempsey JA (2013). Central sleep apnea. Compr Physiol 3, 141-163.
23. Kety SS & Schmidt CF (1948). The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 27, 484-492.
24. Kraaier V, Huffelen AC Van, Wieneke GH, Van Der Worp HB & Bär PR (1992). Quantitative EEG changes due to cerebral vasoconstriction. Indomethacin versus hyperventilation-induced reduction in cerebral blood flow in normal subjects. Electroencephalogr Clin Neurophysiol 82, 208-212.
25. 2 at three levels of carotid chemoreceptor stimulation. Respir Physiol 25, 319-333.
26. Lewis NCS, Messinger L, Monteleone B & Ainslie PN (2014). Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity. J Appl Physiol 116, 1189-1196.
27. Mahamed S & Duffin J (2001). Repeated hypoxic exposures change respiratory chemoreflex control in humans. J Physiol 534, 595-603.
28. Melton JE, Yu QP, Neubauer JA & Edelman NH (1992). Modulation of respiratory responses to carotid sinus nerve stimulation by brain hypoxia. J Appl Physiol 73, 2166-2171.
29. Mitchell R & Loeschcke H (1963). Respiratory responses mediated through superficial chemosensitive areas on the medulla. J Appl Physiol 18, 523-533.
30. Morgan BJ, Reichmuth KJ, Peppard PE, Finn L, Barczi SR, Young T & Nieto FJ (2010). Effects of sleep-disordered breathing on cerebrovascular regulation: A population-based study. Am J Respir Crit Care Med 182, 1445-1452.
31. Neubauer J, Santiago T, Posner M & Edelman N (1985). Ventral medullary pH and ventilatory responses to hyperperfusion and hypoxia. J Appl Physiol 58, 1659-1668.
32. Ogoh S, Sato K, Nakahara H, Okazaki K, Subudhi AW & Miyamoto T (2013). Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries. Exp Physiol 98, 692-698.
33. 2 reactivity to end-tidal, arterial and internal jugular vein PCO2. J Physiol 584, 347-357.
34. Poulin MJ & Robbins PA (1998). Influence of cerebral blood flow on the ventilatory response to hypoxia in humans. Exp Physiol 83, 95-106.
35. Powell FL, Milsom WK & Mitchell GS (1998). Time domains of the hypoxic ventilatory response. Respir Physiol 112, 123-134.
36. Querido JS, Ainslie PN, Foster GE, Henderson WR, Halliwill JR, Ayas NT & Sheel AW (2013). Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide. J Appl Physiol 114, 1183-1190.
37. Read DJ & Leigh J (1967). Blood-brain tissue PCO2 relationships and ventilation during rebreathing. J Appl Physiol 23, 53-70.
38. Regan RE, Fisher JA & Duffin J (2014). Factors affecting the determination of cerebrovascular reactivity. Brain Behav 4, 775-788.
39. Robbins P (1995). Hypoxic ventilatory decline: Site of action. J Appl Physiol 79, 373-374.
40. Sato M, Severinghaus JW, Powell FL, Xu F & Spellman M (1992). Augmented hypoxic ventilatory in men at altitude. J Appl Physiol 73, 101-107.
41. 2 dissociation computations. J Appl Physiol 46, 599-602.
42. 2 reactivity in anterior and posterior cerebral circulations. Respir Physiol Neurobiol 189, 76-86.
43. Solin P, Roebuck T, Johns DP, Walters EH & Naughton MT (2000). Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. Am J Respir Crit Care Med 162, 2194-2200.
44. Staessen J, Cattaert AN, Fagard R, Lijnen P, Moerman E, De Schaepdryver A & Amery A (1984). Hemodynamic and humoral effects of prostaglandin inhibition in exercising humans. J Appl Physiol 56, 39-45.
45. Steinback CD & Poulin MJ (2007). Ventilatory responses to isocapnic and poikilocapnic hypoxia in humans. Respir Physiol Neurobiol 155, 104-113.
46. Suzuki A, Nishimura M, Yamamoto H, Miyamoto K, Kishi F & Kawakami Y (1989). No effect of brain blood flow on ventilatory depression during sustained hypoxia. J Appl Physiol 66, 1674-1678.
47. 2 in congestive heart failure patients with and without central sleep apnea. J Appl Physiol 91, 408-416.
48. Verbree J, Bronzwaer AGT, Ghariq E, Versluis MJ, Daeman MJAP, van Buchem MA, Dahan A, van Lieshout JJ & van Osch MJP (2014). Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra high-field MRI. J Appl Physiol 117, 1084-1089.
49. Wennmalm A, Carlsson I, Edlund A, Eriksson S, Kaijser L & Nowak J (1984). Central and peripheral haemodynamic effects of non-steroidal anti-inflammatory drugs in man. Arch Toxicol Suppl 7, 350-359.
50. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ et al. (2011). Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 196, 221-237.
51. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA & Ainslie PN (2012). Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590, 3261-3275.
52. Willie CK, Smith KJ, Day TA, Ray LA, Lewis NCS, Bakker A, Macleod DB & Ainslie PN (2013). Regional cerebral blood flow in humans at high altitude: Gradual ascent and two weeks at 5050 m. J Appl Physiol 116, 905-910.
53. Wilson MH, Edsell MEG, Davagnanam I, Hirani SP, Martin DS, Levett DZH, Thornton JS, Golay X, Strycharczuk L, Newman SP et al. (2011). Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia - an ultrasound and MRI study. J Cereb Blood Flow Metab 31, 2019-2029.
54. Wolff HG & Lennox WG (1930). Cerebral circulation: XII. The effect on pial vessels of variations in the oxygen and carbon dioxide content of the blood. Arch Neurol Psychiatry 23, 1097.
55. Xie A, Rutherford R, Rankin F, Wong B & Bradley TD (1995). Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea. Am J Respir Crit Care Med 152, 1950-1955.
56. Xie A, Skatrud JB, Barczi SR, Reichmuth K, Morgan BJ, Mont S & Dempsey JA (2009). Influence of cerebral blood flow on breathing stability. J Appl Physiol 106, 850-856.
57. Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B & Russell D (2005). Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med 172, 371-378.
58. Xie A, Skatrud JB, Morgan B, Chenuel B, Khayat R, Reichmuth K, Lin J & Dempsey JA (2006). Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol 577, 319-329.