The effect of hypercapnia on static cerebral autoregulation

Physiological Reports

Volumn 2, Issue 6, 2014, Pages

  Perry, Blake G ^a   Lucas, Samuel J E ^b,c   Thomas, Kate N ^c   Cochrane, Darryl J ^a   Mündel, Toby ^a  

^a MASSEY UNIVERSITY   (New Zealand)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cerebral blood flow; Hypercapnia; Lower body positive pressure; Static cerebral autoregulation

Indexed keywords

CARBON DIOXIDE;

ADULT; ARTICLE; AUTOREGULATION; BLOOD FLOW VELOCITY; BLOOD PRESSURE MONITORING; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART OUTPUT; HEART RATE; HUMAN; HYPERCAPNIA; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; PHOTOELECTRIC PLETHYSMOGRAPHY; RANDOMIZED CONTROLLED TRIAL; REST; STATIC CEREBRAL AUTOREGULATION; STEADY STATE;

EID: 85003454613     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12059     Document Type: Article

References (44)

1. Aaslid, R., K. F. Lindegaard, W. Sorteberg, and H. Nornes. 1989. Cerebral autoregulation dynamics in humans. Stroke 20:45-52.
2. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296:R1473-R1495.
3. 2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J. Physiol. 566:613-624.
4. Battisti-Charbonney, A., J. Fisher, and J. Duffin. 2011. The cerebrovascular response to carbon dioxide in humans. J. Physiol. 589:3039-3048.
5. Bill, A., and J. Linder. 1976. Sympathetic control of cerebral blood flow in acute arterial hypertension. Acta Physiol. Scand. 96:114-121.
6. Busija, D., and D. Heistad. 1984. Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits. J. Physiol. 347:35-45.
7. Busija, D. W., D. D. Heistad, and M. L. Marcus. 1980. Effects of sympathetic nerves on cerebral vessels during acute, moderate increases in arterial pressure in dogs and cats. Circ. Res. 46:696-702.
8. Cassaglia, P. A., R. I. Griffiths, and A. M. Walker. 2008. Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:1255-1261.
9. Claassen, J. A. H. R., R. Zhang, Q. Fu, S. Witkowski, and B. D. Levine. 2007. Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing. J. Appl. Physiol. 102:870-877.
10. Claassen, J. A. H. R., B. D. Levine, and R. Zhang. 2009. Dynamic cerebral autoregulation during repeated squat-stand maneuvers. J. Appl. Physiol. 106:153-160.
11. Edwards, M. R., D. H. Martin, and R. L. Hughson. 2002. Cerebral hemodynamics and resistance exercise. Med. Sci. Sports Exerc. 34:1207-1211.
12. Fu, Q., Y. Sugiyama, A. Kamiya, A. Shamsuzzaman, and T. Mano. 1998. Responses of muscle sympathetic nerve activity to lower body positive pressure. Am. J. Physiol. Heart Circ. Physiol. 275:1254-1259.
13. Giller, C. A., G. Bowman, H. Dyer, L. Mootz, and W. Krippner. 1993. Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32:737-742.
14. Hamner, J., C. O. Tan, K. Lee, M. A. Cohen, and J. A. Taylor. 2010. Sympathetic control of the cerebral vasculature in humans. Stroke 41:102-109.
15. Iadecola, C., and F. Zhang. 1996. Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine. Am. J. Physiol. Regul. Integr. Comp. Physiol. 271:R990-R1001.
16. 2 in the hypocapnic-hypercapnic range in humans. J. Appl. Physiol. 95:129-137.
17. Jordan, J., J. R. Shannon, A. Diedrich, B. Black, F. Costa, D. Robertson, et al. 2000. Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension 36: 383-388.
18. Kety, S. S., and C. F. Schmidt. 1948. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J. Clin. Invest. 27:484-492.
19. Lassen, N. A. 1959. Cerebral blood flow and oxygen consumption in man. Physiol. Rev. 39:183-238.
20. 2 responsiveness in humans. J. Physiol. 551:609-616.
21. Liu, J., Y.-S. Zhu, C. Hill, K. Armstrong, T. Tarumi, T. Hodics, et al. 2013. Cerebral autoregulation of blood velocity and volumetric flow during steady-state changes in arterial pressure. Hypertension 62:973-979. doi: 10.1161/HYPERTENSIONAHA.1113.01867.
22. Lucas, S. J. E., Y. C. Tzeng, S. D. Galvin, K. N. Thomas, S. Ogoh, and P. N. Ainslie. 2010. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55:698-705.
23. Maggio, P., A. S. Salinet, R. B. Panerai, and T. G. Robinson. 2013. Does hypercapnia-induced impairment of cerebral autoregulation affect neurovascular coupling? A functional TCD study. J. Appl. Physiol. 115:491-497. doi:10.1152/japplphysiol.00327.02013.
24. Morgan, B. J., D. C. Crabtree, M. Palta, and J. B. Skatrud. 1995. Combined hypoxia and hypercapnia evokes long-lasting sympathetic activation in humans. J. Appl. Physiol. 79:205-213.
25. Ogoh, S., and P. N. Ainslie. 2009. Cerebral blood flow during exercise: mechanisms of regulation. J. Appl. Physiol. 107:1370-1380.
26. Ogoh, S., R. M. Brothers, Q. Barnes, W. L. Eubank, M. N. Hawkins, and S. Purkayastha. 2005. The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J. Physiol. 569:697-704.
27. Ogoh, S., K. Sato, J. P. Fisher, T. Seifert, M. Overgaard, and N. H. Secher. 2011. The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects. Clin. Physiol. Funct. Imaging 31:445-451.
28. Peebles, K. C., A. M. Richards, L. Celi, K. McGrattan, C. J. Murrell, and P. N. Ainslie. 2008. Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. J. Appl. Physiol. 105:1060-1068.
29. Peebles, K. C., O. G. Ball, B. A. MacRae, H. M. Horsman, and Y.-C. Tzeng. 2012. Sympathetic regulation of the human cerebrovascular response to carbon dioxide. J. Appl. Physiol. 113:700-706.
30. Perry, B. G., Z. J. Schlader, A. Raman, D. J. Cochrane, S. J. Lucas, and T. Mündel. 2013. Middle cerebral artery blood flow velocity in response to lower body positive pressure. Clin. Physiol. Funct. Imaging 33:483-488. doi:10.1111/cpf.12046.
31. Przybylowski, T., M. F. Bangash, K. Reichmuth, B. J. Morgan, J. B. Skatrud, and J. A. Dempsey. 2003. Mechanisms of the cerebrovascular response to apnoea in humans. J. Physiol. 548:323-332.
32. 2 in human internal and external carotid and vertebral arteries. J. Physiol. 590:3277-3290.
33. Shi, X., B. H. Foresman, and P. B. Raven. 1997. Interaction of central venous pressure, intramuscular pressure, and carotid baroreflex function. Am. J. Physiol. Heart Circ. Physiol. 272:1359-1363.
34. Tiecks, F. P., A. M. Lam, R. Aaslid, and D. W. Newell. 1995a. Comparison of static and dynamic cerebral autoregulation measurements. Stroke 26:1014-1019.
35. Tiecks, F. P., A. M. Lam, B. F. Matta, S. Strebel, C. Douville, and D. W. Newell. 1995b. Effects of the Valsalva maneuver on cerebral circulation in healthy adults: a transcranial Doppler study. Stroke 26:1386-1392.
36. Tzeng, Y.-C., and P. N. Ainslie. 2013. Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges. Eur. J. Appl. Physiol. 114:545-559.
37. Tzeng, Y. C., C. K. Willie, G. Atkinson, S. J. E. Lucas, A. Wong, and P. N. Ainslie. 2010. Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension 56:268-273.
38. Valdueza, J. M., J. O. Balzer, A. Villringer, T. J. Vogl, R. Kutter, and K. Einh. 1997. Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography. Am. J. Neuroradiol. 18: 1929-1934.
39. Van Lieshout, J. J., and N. H. Secher. 2008. Point: counterpoint: sympathetic activity does/does not influence cerebral blood flow. J. Appl. Physiol. 105:1364-1366.
40. Wesseling, K., J. Jansen, J. Settels, and J. Schreuder. 1993. Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J. Appl. Physiol. 74:2566-2573.
41. Willie, C. K., D. B. Macleod, A. D. Shaw, K. J. Smith, Y. C. Tzeng, N. D. Eves, et al. 2012. Regional brain blood flow in man during acute changes in arterial blood gases. J. Physiol. 590:3261-3275.
42. Zhang, R., J. H. Zuckerman, C. A. Giller, and B. D. Levine. 1998. Transfer function analysis of dynamic cerebral autoregulation in humans. Am. J. Physiol. Heart Circ. Physiol. 274:233-241.
43. Zhang, R., J. H. Zuckerman, and B. D. Levine. 2000. Spontaneous fluctuations in cerebral blood flow: insights from extended-duration recordings in humans. Am. J. Physiol. Heart Circ. Physiol. 278:H1848-H1855.
44. Zhang, R., J. H. Zuckerman, K. Iwasaki, T. E. Wilson, C. G. Crandall, and B. D. Levine. 2002. Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 106:1814-1820.