메뉴 건너뛰기




Volumn 10, Issue , 2015, Pages 3921-3935

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: Preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Author keywords

Bioavailability; Biodistribution; Nanoparticles; Pharmacokinetics; Poly (n butylcyanoacrylate); Quercetin

Indexed keywords

NANOPARTICLE; POLY(N BUTYLCYANOACRYLATE)NANOPARTICLE; POLYSORBATE 80; QUERCITRIN; UNCLASSIFIED DRUG; BIOCOMPATIBLE COATED MATERIAL; DRUG CARRIER; ENBUCRILATE; POLYSORBATE; QUERCETIN;

EID: 84933525096     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S80706     Document Type: Article
Times cited : (99)

References (51)
  • 2
    • 10044246299 scopus 로고    scopus 로고
    • Review of the favonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology
    • Erlund I. Review of the favonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res. 2004;24(10):851–874.
    • (2004) Nutr Res , vol.24 , Issue.10 , pp. 851-874
    • Erlund, I.1
  • 3
    • 69149085268 scopus 로고    scopus 로고
    • Protective mechanism of quercetin and rutin using glutathione metabolism on H2O2-induced oxidative stress in HepG2 cells
    • Kim GN, Jang HD. Protective mechanism of quercetin and rutin using glutathione metabolism on H2O2-induced oxidative stress in HepG2 cells. Ann N Y Acad Sci. 2009;1171:530–537.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 530-537
    • Kim, G.N.1    Jang, H.D.2
  • 4
    • 0029610477 scopus 로고
    • Review of the biology of quercetin and related biofavonoid
    • Formica JV, Regelson W. Review of the biology of quercetin and related biofavonoid. Food Chem Toxicol. 1995;33(12):1061–1080.
    • (1995) Food Chem Toxicol , vol.33 , Issue.12 , pp. 1061-1080
    • Formica, J.V.1    Regelson, W.2
  • 6
    • 77649274804 scopus 로고    scopus 로고
    • Effect of dietary quercetin on brain quercetin levels and the expression of antioxidant and Alzheimer’s disease relevant genes in mice
    • Huebbe P, Wagner AE, Boesch-Saadatmandi C, Sellmer F, Wolffram S, Rimbach G. Effect of dietary quercetin on brain quercetin levels and the expression of antioxidant and Alzheimer’s disease relevant genes in mice. Pharmacol Res. 2010;61(3):242–246.
    • (2010) Pharmacol Res , vol.61 , Issue.3 , pp. 242-246
    • Huebbe, P.1    Wagner, A.E.2    Boesch-Saadatmandi, C.3    Sellmer, F.4    Wolffram, S.5    Rimbach, G.6
  • 8
    • 79952229207 scopus 로고    scopus 로고
    • Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery
    • Dhawan S, Kapil R, Singh B. Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery. J Pharm Pharmacol. 2011;63(3):342–351.
    • (2011) J Pharm Pharmacol , vol.63 , Issue.3 , pp. 342-351
    • Dhawan, S.1    Kapil, R.2    Singh, B.3
  • 9
    • 32244438967 scopus 로고    scopus 로고
    • Design of estradiol loaded PLGA nanoparticulate formulations: A potential oral delivery system for hormone therapy
    • Hariharan S, Bhardwaj V, Bala I, Sitterberg J, Bakowsky U, Ravi Kumar MNV. Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy. Pharm Res. 2006;23(1):184–195.
    • (2006) Pharm Res , vol.23 , Issue.1 , pp. 184-195
    • Hariharan, S.1    Bhardwaj, V.2    Bala, I.3    Sitterberg, J.4    Bakowsky, U.5    Ravi Kumar, M.6
  • 10
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of nanoparticles
    • LI SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm. 2008;5(4):496–504.
    • (2008) Mol Pharm , vol.5 , Issue.4 , pp. 496-504
    • Li, S.D.1    Huang, L.2
  • 11
    • 79958251735 scopus 로고    scopus 로고
    • Lecithin based novel cationic nanocarriers (LeciPlex) II: Improving therapeutic efficacy of quercetin on oral administration
    • Date AA, Nagarsenker MS, Patere S, et al. Lecithin based novel cationic nanocarriers (LeciPlex) II: improving therapeutic efficacy of quercetin on oral administration. Mol Pharm. 2011;8(3):716–726.
    • (2011) Mol Pharm , vol.8 , Issue.3 , pp. 716-726
    • Date, A.A.1    Nagarsenker, M.S.2    Patere, S.3
  • 12
    • 36949029575 scopus 로고    scopus 로고
    • Physicochemical characterization and antioxidant activity of quercetin-loaded chitosan nanoparticles
    • Zhang Y, Yang Y, Tang K, Hu X, Zou G. Physicochemical characterization and antioxidant activity of quercetin-loaded chitosan nanoparticles. J Appl Polym Sci. 2008;107(2):891–897.
    • (2008) J Appl Polym Sci , vol.107 , Issue.2 , pp. 891-897
    • Zhang, Y.1    Yang, Y.2    Tang, K.3    Hu, X.4    Zou, G.5
  • 13
    • 84862091669 scopus 로고    scopus 로고
    • Liposomal quercetin: Evaluating drug delivery in vitro and biodistribution in vivo
    • Gang W, Jie WJ, Ping ZL, et al. Liposomal quercetin: evaluating drug delivery in vitro and biodistribution in vivo. Expert Opin Drug Deliv. 2012;9(6):599–613.
    • (2012) Expert Opin Drug Deliv , vol.9 , Issue.6 , pp. 599-613
    • Gang, W.1    Jie, W.J.2    Ping, Z.L.3
  • 14
    • 84867028105 scopus 로고    scopus 로고
    • Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles
    • Pool H, Quintanar D, Figueroa JD, et al. Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles. J Nanomat. 2012: Article ID 145380: 1–12.
    • J Nanomat , vol.145-380 , pp. 1-12
    • Pool, H.1    Quintanar, D.2    Figueroa, J.D.3
  • 15
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev. 2001;47(1):65–81.
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.1 , pp. 65-81
    • Kreuter, J.1
  • 16
    • 84874735141 scopus 로고    scopus 로고
    • Poly(alkyl cyanoacrylate) nanoparticles as drug carriers: 33 years later
    • Yordanov G. Poly(alkyl cyanoacrylate) nanoparticles as drug carriers: 33 years later. Bulg J Chem. 2012;1:61–73.
    • (2012) Bulg J Chem , vol.1 , pp. 61-73
    • Yordanov, G.1
  • 17
    • 78649909357 scopus 로고    scopus 로고
    • Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticles
    • Sun M, Gao Y, Guo C, et al. Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticles. J Nanopart Res. 2010;12:3111–3122.
    • (2010) J Nanopart Res , vol.12 , pp. 3111-3122
    • Sun, M.1    Gao, Y.2    Guo, C.3
  • 18
    • 81555201186 scopus 로고    scopus 로고
    • Enhancement of oral bioavailability of puer-arin by polybutylcyanoacrylate nanoparticles
    • Zhao L, Liu A, Sun M, et al. Enhancement of oral bioavailability of puer-arin by polybutylcyanoacrylate nanoparticles. J Nanomater. 2011:1–8.
    • (2011) J Nanomater , pp. 1-8
    • Zhao, L.1    Liu, A.2    Sun, M.3
  • 19
    • 40849097322 scopus 로고    scopus 로고
    • Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of Rivastigmine into the brain to treat Alzheimer’s disease
    • Wilson B, Samanta MK, Santhi K, Sampath Kumar KP, Paramakrishnan N, Suresh B. Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of Rivastigmine into the brain to treat Alzheimer’s disease. Brain Res. 2008;1200:159–168.
    • (2008) Brain Res , vol.1200 , pp. 159-168
    • Wilson, B.1    Samanta, M.K.2    Santhi, K.3    Sampath Kumar, K.P.4    Paramakrishnan, N.5    Suresh, B.6
  • 20
    • 0032712180 scopus 로고    scopus 로고
    • Significant transport of doxorubicin into the brain with polysor-bate 80-coated nanoparticles
    • Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J. Significant transport of doxorubicin into the brain with polysor-bate 80-coated nanoparticles. Pharm Res. 1999;16(10):1564–1569.
    • (1999) Pharm Res , vol.16 , Issue.10 , pp. 1564-1569
    • Gulyaev, A.E.1    Gelperina, S.E.2    Skidan, I.N.3    Antropov, A.S.4    Kivman, G.Y.5    Kreuter, J.6
  • 21
    • 84867102456 scopus 로고    scopus 로고
    • Influence of the preparation method on the physi-cochemical properties of econazole-loaded poly(butyl cyanoacrylate) colloidal nanoparticles
    • Yordanov G. Influence of the preparation method on the physi-cochemical properties of econazole-loaded poly(butyl cyanoacrylate) colloidal nanoparticles. Colloids Surf A Physicochem Eng Asp. 2012; 413:260–265.
    • (2012) Colloids Surf a Physicochem Eng Asp , vol.413 , pp. 260-265
    • Yordanov, G.1
  • 22
    • 0028911362 scopus 로고
    • Passage of pep-tides through the blood–brain barrier with colloidal polymer particles (nanoparticles)
    • Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA. Passage of pep-tides through the blood–brain barrier with colloidal polymer particles (nanoparticles). Brain Res. 1995;674(1):171–174.
    • (1995) Brain Res , vol.674 , Issue.1 , pp. 171-174
    • Kreuter, J.1    Alyautdin, R.N.2    Kharkevich, D.A.3    Ivanov, A.A.4
  • 23
    • 0033993565 scopus 로고    scopus 로고
    • Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system
    • Friese A, Seiller E, Quack G, Lorenz B, Kreuter J. Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system. Eur J Pharm Biopharm. 2000;49(2):103–109.
    • (2000) Eur J Pharm Biopharm , vol.49 , Issue.2 , pp. 103-109
    • Friese, A.1    Seiller, E.2    Quack, G.3    Lorenz, B.4    Kreuter, J.5
  • 24
    • 0032484038 scopus 로고    scopus 로고
    • Development of ciprofloxacin-loaded nanopar-ticles: Physicochemical study of the drug carrier
    • Page-Clisson ME, Pinto-Alphandary H, Ourevitch M, Andremont A, Couvreur P. Development of ciprofloxacin-loaded nanopar-ticles: physicochemical study of the drug carrier. J Control Release. 1998;56(1–3):23–32.
    • (1998) J Control Release , vol.56 , Issue.1-3 , pp. 23-32
    • Page-Clisson, M.E.1    Pinto-Alphandary, H.2    Ourevitch, M.3    Remont, A.4    Couvreur, P.5
  • 25
    • 0141764822 scopus 로고    scopus 로고
    • Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: In vitro release and in vivo skin penetration
    • Miyazaki S, Takahashi A, Kubo W, Bachynsky J, Loebenberg R. Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration. J Pharm Pharm Sci. 2003; 6(2):238–245.
    • (2003) J Pharm Pharm Sci , vol.6 , Issue.2 , pp. 238-245
    • Miyazaki, S.1    Takahashi, A.2    Kubo, W.3    Bachynsky, J.4    Loebenberg, R.5
  • 26
    • 33750512963 scopus 로고    scopus 로고
    • Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate–sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across thein vitroblood–brain barrier
    • Kuo YC, Chen HH. Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate–sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across thein vitroblood–brain barrier. Int J Pharm. 2006;327(1–2):160–169.
    • (2006) Int J Pharm , vol.327 , Issue.1-2 , pp. 160-169
    • Kuo, Y.C.1    Chen, H.H.2
  • 27
    • 79960901437 scopus 로고    scopus 로고
    • Kinetics of transport of doxorubicin bound to nanoparticles across the blood– brain barrier
    • Wohlfart S, Khalansky AS, Gelperina S, Begley D, Kreuter J. Kinetics of transport of doxorubicin bound to nanoparticles across the blood– brain barrier. J Control Release. 2011;154:103–107.
    • (2011) J Control Release , vol.154 , pp. 103-107
    • Wohlfart, S.1    Khalansky, A.S.2    Gelperina, S.3    Begley, D.4    Kreuter, J.5
  • 28
    • 33344460518 scopus 로고    scopus 로고
    • Infuence of particle size on transport of methotrexate across blood–brain barrier by polysorbate 80-coated polybutylcyano-acrylate nanoparticles
    • Gao K, Jiang X. Infuence of particle size on transport of methotrexate across blood–brain barrier by polysorbate 80-coated polybutylcyano-acrylate nanoparticles. Int J Pharm. 2006;310(1–2):213–219.
    • (2006) Int J Pharm , vol.310 , Issue.1-2 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 29
    • 77957260011 scopus 로고    scopus 로고
    • Rivastigmine-loaded PLGA and PBCA nanoparticles: Preparation, optimization, characterization, in vitro and pharmacodynamic studies
    • Joshi SA, Chavhan SS, Sawant KK. Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies. Eur J Pharm Biopharm. 2010; 76(2):189–189.
    • (2010) Eur J Pharm Biopharm , vol.76 , Issue.2 , pp. 189
    • Joshi, S.A.1    Chavhan, S.S.2    Sawant, K.K.3
  • 30
    • 50149094833 scopus 로고    scopus 로고
    • Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles
    • Wilson B, Sampath KP, Santhi K, Kumar KPS, Paramakrishnan N, Suresh B. Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles. Eur Pharm Bio-pharm. 2008;70:75–84.
    • (2008) Eur Pharm Bio-Pharm , vol.70 , pp. 75-84
    • Wilson, B.1    Sampath, K.P.2    Santhi, K.3    Kumar, K.4    Paramakrishnan, N.5    Suresh, B.6
  • 31
    • 84870321542 scopus 로고    scopus 로고
    • PLGA nanoparticles loaded with etoposide and quercetin dihydrate individually: In vitro cell line study to ensure advantage of combination therapy
    • Pimple S, Manjappa AS, Ukawala M, Murthy RSR. PLGA nanoparticles loaded with etoposide and quercetin dihydrate individually: in vitro cell line study to ensure advantage of combination therapy. Cancer Nanotechnol. 2012;3:25–36.
    • (2012) Cancer Nanotechnol , vol.3 , pp. 25-36
    • Pimple, S.1    Manjappa, A.S.2    Ukawala, M.3    Murthy, R.4
  • 32
    • 21344466290 scopus 로고    scopus 로고
    • Double-coated poly(butylcyanoacrylate) nanoparticulate delivery systems of brain targeting of dalargin via oral administration
    • Das D, Lin S. Double-coated poly(butylcyanoacrylate) nanoparticulate delivery systems of brain targeting of dalargin via oral administration. J Pharm Sci. 2005;94(6):1343–1353.
    • (2005) J Pharm Sci , vol.94 , Issue.6 , pp. 1343-1353
    • Das, D.1    Lin, S.2
  • 33
    • 84872108464 scopus 로고    scopus 로고
    • Formulation optimization and topical delivery of quercetin from solid lipid based nanosys-tems
    • Bose S, Duc Y, Takhistov P, Michniak-Kohn B. Formulation optimization and topical delivery of quercetin from solid lipid based nanosys-tems. Int J Pharm. 2013;441(1–2):56–66.
    • (2013) Int J Pharm , vol.441 , Issue.1-2 , pp. 56-66
    • Bose, S.1    Duc, Y.2    Takhistov, P.3    Michniak-Kohn, B.4
  • 34
    • 79960297652 scopus 로고    scopus 로고
    • Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
    • Tian X, Lin X, Wei F, et al. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. Int J Nanomedicine. 2011;6:445–452.
    • (2011) Int J Nanomedicine , vol.6 , pp. 445-452
    • Tian, X.1    Lin, X.2    Wei, F.3
  • 35
    • 84883596511 scopus 로고    scopus 로고
    • Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: Implications for drug-induced cardiotoxicity and nephrotoxicity
    • Jain S, Jain AK, Pohekar M, Thanki K. Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity. Free Radic Biol Med. 2013;65:117–130.
    • (2013) Free Radic Biol Med , vol.65 , pp. 117-130
    • Jain, S.1    Jain, A.K.2    Pohekar, M.3    Thanki, K.4
  • 36
    • 84872764574 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles
    • Bhandari R, Kaur IP. Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles. Int J Pharm. 2013;441(1–2):202–212.
    • (2013) Int J Pharm , vol.441 , Issue.1-2 , pp. 202-212
    • Bhandari, R.1    Kaur, I.P.2
  • 37
    • 3242733120 scopus 로고    scopus 로고
    • Infuence of polymerization technique and experimental variables on the particle properties and release kinetics of methotrexate from poly(butylcyanoacrylate) nanoparticles
    • Reddy LH, Murthy RR. Infuence of polymerization technique and experimental variables on the particle properties and release kinetics of methotrexate from poly(butylcyanoacrylate) nanoparticles. Acta Pharm. 2004;54:103–118.
    • (2004) Acta Pharm , vol.54 , pp. 103-118
    • Reddy, L.H.1    Murthy, R.R.2
  • 38
    • 23044521799 scopus 로고    scopus 로고
    • Mechanism of polymerization of butylcyano-acrylate in aqueous dispersions
    • Behan N, Birkinshaw C. Mechanism of polymerization of butylcyano-acrylate in aqueous dispersions. Macromol Rapid Commun. 2000;21: 884–886.
    • (2000) Macromol Rapid Commun , vol.21 , pp. 884-886
    • Behan, N.1    Birkinshaw, C.2
  • 39
    • 0035371978 scopus 로고    scopus 로고
    • Polyn-butyl cyanoacrylate nanopar-ticles: A mechanistic study of polymerisation and particle formation
    • Behan N, Birkinshaw C, Clarke N. Polyn-butyl cyanoacrylate nanopar-ticles: a mechanistic study of polymerisation and particle formation. Biomaterials. 2001;22(11):1335–1344.
    • (2001) Biomaterials , vol.22 , Issue.11 , pp. 1335-1344
    • Behan, N.1    Birkinshaw, C.2    Clarke, N.3
  • 40
    • 84864398910 scopus 로고    scopus 로고
    • Colloidal formulations of etoposide based on poly(butyl cyanoacrylate) nanoparticles: Preparation, physicochemical properties and cytotoxicity
    • Yordanov G, Skrobanska R, Evangelatov A. Colloidal formulations of etoposide based on poly(butyl cyanoacrylate) nanoparticles: preparation, physicochemical properties and cytotoxicity. Colloids Surf B Biointerfaces. 2013;101:215–222.
    • (2013) Colloids Surf B Biointerfaces , vol.101 , pp. 215-222
    • Yordanov, G.1    Skrobanska, R.2    Evangelatov, A.3
  • 41
    • 42649107490 scopus 로고    scopus 로고
    • Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism
    • Huang J, Si L, Jiang L, Fan Z, Qiu J, Li G. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. 2008;356:351–353.
    • (2008) Int J Pharm , vol.356 , pp. 351-353
    • Huang, J.1    Si, L.2    Jiang, L.3    Fan, Z.4    Qiu, J.5    Li, G.6
  • 42
    • 77957678756 scopus 로고    scopus 로고
    • Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles
    • Duan J, Zhang Y, Han S, et al. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm. 2010;400(1–2):211–220.
    • (2010) Int J Pharm , vol.400 , Issue.1-2 , pp. 211-220
    • Duan, J.1    Zhang, Y.2    Han, S.3
  • 43
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery-are view of the state of the art
    • Muller RH, Mader K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-are view of the state of the art. Eur J Pharm Biopharm. 2000;50:161–177.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 161-177
    • Muller, R.H.1    Mader, K.2    Gohla, S.3
  • 44
    • 36048934038 scopus 로고    scopus 로고
    • Preparation, physicochemi-cal characterization, and antioxidant effect of quercetin nanoparticles
    • Wu T, Ye n F, Lin L, Tsai T, Lin C, Cham T. Preparation, physicochemi-cal characterization, and antioxidant effect of quercetin nanoparticles. Int J Pharm. 2008;346(1–2):160–168.
    • (2008) Int J Pharm , vol.346 , Issue.1-2 , pp. 160-168
    • Wu, T.1    Ye N, F.2    Lin, L.3    Tsai, T.4    Lin, C.5    Cham, T.6
  • 46
    • 67349137064 scopus 로고    scopus 로고
    • Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study
    • Mulik R, Mahadik K, Paradkar A. Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: physicochemical characterization and stability study. Eur J Pharm Sci. 2009;37(3–4):395–404.
    • (2009) Eur J Pharm Sci , vol.37 , Issue.3-4 , pp. 395-404
    • Mulik, R.1    Mahadik, K.2    Paradkar, A.3
  • 47
    • 17744396286 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavail-ability of quercetin glycosides in humans
    • Graefe EU, Wittig J, Mueller S, et al. Pharmacokinetics and bioavail-ability of quercetin glycosides in humans. J Clin Pharmacol. 2001; 41(5):492–499.
    • (2001) J Clin Pharmacol , vol.41 , Issue.5 , pp. 492-499
    • Graefe, E.U.1    Wittig, J.2    Mueller, S.3
  • 48
    • 0033457965 scopus 로고    scopus 로고
    • Comparison of the bioavail-ability of quercetin and catechin in rats
    • Manach C, Texier O, Morand C, et al. Comparison of the bioavail-ability of quercetin and catechin in rats. Free Radic Biol Med. 1999; 27(11–12):1259–1266.
    • (1999) Free Radic Biol Med , vol.27 , Issue.11-12 , pp. 1259-1266
    • Manach, C.1    Texier, O.2    Morand, C.3
  • 49
    • 84883581837 scopus 로고    scopus 로고
    • Co-encapsulation of tamoxifen and quer-cetin in polymeric nanoparticles: Implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity
    • Jain AK, Thanki K, Jain S. Co-encapsulation of tamoxifen and quer-cetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Mol Pharm. 2013;10(9): 3459–3474.
    • (2013) Mol Pharm , vol.10 , Issue.9 , pp. 3459-3474
    • Jain, A.K.1    Thanki, K.2    Jain, S.3
  • 50
    • 58049191302 scopus 로고    scopus 로고
    • Nanoencapsula-tion of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats
    • Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. Nanoencapsula-tion of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci. 2009;84: 75–80.
    • (2009) Life Sci , vol.84 , pp. 75-80
    • Ghosh, A.1    Mandal, A.K.2    Sarkar, S.3    Panda, S.4    Das, N.5
  • 51
    • 0031962120 scopus 로고    scopus 로고
    • Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: An in situ brain perfusion study
    • Alyautdin RN, Tezikov EB, Ramge P, Kharkevich DA, Begley DJ, Kreuter J. Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study. J Microencapsul. 1998;15(1):67–74.
    • (1998) J Microencapsul , vol.15 , Issue.1 , pp. 67-74
    • Alyautdin, R.N.1    Tezikov, E.B.2    Ramge, P.3    Kharkevich, D.A.4    Begley, D.J.5    Kreuter, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.