Delayed Anaphylaxis Involving IgE to Galactose-alpha-1,3-galactose

Current Allergy and Asthma Reports

Volumn 15, Issue 4, 2015, Pages

  Platts Mills, Thomas A E ^a   Schuyler, Alexander J ^a   Hoyt, Alice E W ^a   Commins, Scott P ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Alpha gal; Food allergy; IgE; Mammalian meat

Indexed keywords

CETUXIMAB; GALACTOSYLGALACTOSE; IMMUNOGLOBULIN E ANTIBODY; VARICELLA ZOSTER VACCINE; ALLERGEN; DISACCHARIDE; EPITOPE; GALACTOSE; IMMUNOGLOBULIN E;

ALLERGY; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ANTIBODY SPECIFICITY; CHILDHOOD; DAIRY PRODUCT; DELAYED HYPERSENSITIVITY; DIAGNOSTIC ERROR; DIET RESTRICTION; DRUG HYPERSENSITIVITY; FOOD ALLERGY; GASTROINTESTINAL SYMPTOM; GLYCOSYLATION; HAND PALM; HEART VALVE PROSTHESIS; HUMAN; IMMUNOLOGICAL TOLERANCE; MEDICAL HISTORY; NONHUMAN; ONSET AGE; POSTOPERATIVE COMPLICATION; PRICK TEST; PRURITUS; RECURRENT DISEASE; RED MEAT; REVIEW; SYMPTOMATOLOGY; TICK BITE; URTICARIA; ANIMAL; IMMUNOLOGY;

ALLERGENS; ANAPHYLAXIS; ANIMALS; DISACCHARIDES; EPITOPES; FOOD HYPERSENSITIVITY; GALACTOSE; HUMANS; IMMUNOGLOBULIN E;

EID: 84933509980     PISSN: 15297322     EISSN: 15346315     Source Type: Journal    
DOI: 10.1007/s11882-015-0512-6     Document Type: Review

References (32)

1. Aalberse RC, van Ree R. Crossreactive carbohydrate determinants. Clin Rev Allergy Immunol. 1997;15:375–87.
2. van der Veen MJ, van Ree R, Aalberse RC, Akkerdaas J, Koppelman SJ, Jansen HM, et al. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J Allergy Clin Immunol. 1997;100:327–34.
3. van Ree R, Aalberse RC. Specific IgE without clinical allergy. J Allergy Clin Immunol. 1999;103:1000–1.
4. Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N Engl J Med. 2008;358:1109–17.
5. O’Neil BH, Allen R, Spigel DR, Stinchcombe TE, Moore DT, Berlin JD, et al. High incidence of cetuximab-related infusion reactions in Tennessee and North Carolina and the association with atopic history. J Clin Oncol. 2007;25:3644–8.
6. Qian J, Liu T, Yang L, Daus A, Crowley R, Zhou Q. Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion. Anal Biochem. 2007;364:8–18.
7. Ayoub D, Jabs W, Resemann A, Evers W, Evans C, Main L, et al. Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques. MAbs. 2013;5:699–710.
8. Koike C, Uddin M, Wildman DE, Gray EA, Trucco M, Starzl TE, et al. Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Proc Natl Acad Sci U S A. 2007;104:559–64.
9. Galili U. The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy. Immunol Cell Biol. 2005;83:674–86.
10. Maier S, Chung CH, Morse M, Platts-Mills T, Townes L, Mukhopadhyay P, et al. A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reactions. Cancer Med. 2014.
11. Commins SP, Satinover SM, Hosen J, Mozena J, Borish L, Lewis BD, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol. 2009;123:426–33.
12. Thall A, Galili U. Distribution of Gal alpha 1––3Gal beta 1––4GlcNAc residues on secreted mammalian glycoproteins (thyroglobulin, fibrinogen, and immunoglobulin G) as measured by a sensitive solid-phase radioimmunoassay. Biochemistry. 1990;29:3959–65.
13. Kennedy J, Stallings A, Platts-Mills T, Oliveira W, Workman L, James H, et al. Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children. Pediatrics. 2013;131:1–8.
14. Commins SP, James HR, Stevens W, Pochan SL, Land MH, King C, et al. Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose. J Allergy Clin Immunol. 2014;134:108–15.
15. Van Nunen SA, O’Connor KS, Clarke LR, Boyle RX, Fernando SL. An association between tick bite reactions and red meat allergy in humans. Med J Aust. 2009;190:510–1.
16. Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. J Allergy Clin Immunol. 2011;127:1286–1293.e1286.
17. Brown AF, Hamilton DL. Tick bite anaphylaxis in Australia. J Accid Emerg Med. 1998;15:111–3.
18. Gauci M, Loh RK, Stone BF, Thong YH. Allergic reactions to the Australian paralysis tick, Ixodes holocyclus: diagnostic evaluation by skin test and radioimmunoassay. Clin Exp Allergy. 1989;19:279–83.
19. Hamsten C, Starkhammar M, Tran TA, Johansson M, Bengtsson U, Ahlén G, et al. Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy. Allergy. 2013.
20. Mullins RJ, James H, Platts-Mills TA, Commins S. Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose. J Allergy Clin Immunol. 2012;129:1334–1342.e1331.
21. Morisset M, Richard C, Astier C, Jacquenet S, Croizier A, Beaudouin E, et al. Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose. Allergy. 2012;67:699–704.
22. Jacquenet S, Moneret-Vautrin DA, Bihain BE. Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab. J Allergy Clin Immunol. 2009;124:603–5.
23. Jappe U. [Update on meat allergy: α-Gal: a new epitope, a new entity?]. Hautarzt. 2012;63:299–306.
24. Fischer J, Hebsaker J, Caponetto P, Platts-Mills TA, Biedermann T. Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis. J Allergy Clin Immunol. 2014;134:755–759.e751. Interesting report of series of food challenges in European patients with delayed reactions to mammalian meat. The investigators used cofactors (exercise) and organ meats to demonstrate that timing can be influenced by both of these variables.
25. Hamsten C, Tran TA, Starkhammar M, Brauner A, Commins SP, Platts-Mills TA, et al. Red meat allergy in Sweden: association with tick sensitization and B-negative blood groups. J Allergy Clin Immunol. 2013.
26. Gonzalez-Quintela A, Dam Laursen AS, Vidal C, Skaaby T, Gude F, Linneberg A. IgE antibodies to alpha-gal in the general adult population: relationship with tick bites, atopy, and cat ownership. Clin Exp Allergy. 2014;44:1061–8. The prevalence of sIgE to alpha-gal has been a lingering question. The prevalence of alpha-gal sIgE antibodies in two general adult European populations (Denmark and Spain) was found to be 5.5% and 8.1%, respectively. The presence of alpha-gal sIgE antibodies was associated with a history of tick bites, atopy, and cat ownership.
27. Sekiya K, Fukutomi Y, Nakazawa T, Taniguchi M, Akiyama K. Delayed anaphylactic reaction to mammalian meat. J Investig Allergol Clin Immunol. 2012;22:446–7.
28. Lee JH, Kim JH, Kim TH, Kim SC. Delayed mammalian meat-induced anaphylaxis confirmed by skin test to cetuximab. J Dermatol. 2013;40:577–8.
29. Ebo DG, Faber M, Sabato V, Leysen J, Gadisseur A, Bridts CH, et al. Sensitization to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal): experience in a Flemish case series. Acta Clin Belg. 2013;68:206–9.
30. Commins SP, Kelly LA, Rönmark E, James HR, Pochan SL, Peters EJ, et al. Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma. Am J Respir Crit Care Med. 2012;185:723–30.
31. Mozzicato SM, Tripathi A, Posthumus JB, Platts-Mills TA, Commins SP. Porcine or bovine valve replacement in 3 patients with IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose. J Allergy Clin Immunol Pract. 2014;2:637–8.
32. Naso F, Gandaglia A, Bottio T, Tarzia V, Nottle MB, d’Apice AJ, et al. First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses. Xenotransplantation. 2013;20:252–61. The issue of whether the fixation process destroys alpha-gal moieties present on porcine and bovine valves has been the source of speculation and conflicting reports. This recent report demonstrates the presence of alpha-gal on valves and appears to end the discussion.