First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses

Xenotransplantation

Volumn 20, Issue 4, 2013, Pages 252-261

  Naso, Filippo ^a   Gandaglia, Alessandro ^a   Bottio, Tomaso ^a   Tarzia, Vincenzo ^a   Nottle, Mark B ^b   D'Apice, Anthony J F ^c,d   Cowan, Peter J ^c,d   Cozzi, Emmanuele ^a   Galli, Cesare ^e,f   Lagutina, Irina ^e   Lazzari, Giovanna ^e,f,g   Iop, Laura ^a   Spina, Michele ^a   Gerosa, Gino ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e Laboratory of Reproductive Technologies   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g Laboratorio di Tecnologie della Riproduzione   (Italy)

Author keywords

antibody antigen; biomaterials; heart valve bioprosthesis; immunology; xenograft

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; ANTIGEN; EPITOPE; GLUTARALDEHYDE; HETEROANTIGEN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CLINICAL ASSESSMENT; CLINICAL PRACTICE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HEART VALVE BIOPROSTHESIS; IMMUNOFLUORESCENCE TEST; LIMIT OF QUANTITATION; MOSAIC BIOPROSTHESIS; NONHUMAN; PERICARDIUM; PRIORITY JOURNAL; STENT; SWINE; VALVE;

ANTIBODY/ANTIGEN; BIOMATERIALS; HEART VALVE BIOPROSTHESIS; IMMUNOLOGY; XENOGRAFT;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIGENS; CATTLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; GLUTARAL; GRAFT REJECTION; HEART VALVE PROSTHESIS; HEART VALVES; HUMANS; MALE; MATERIALS TESTING; MODELS, ANIMAL; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84881126296     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12044     Document Type: Article

References (45)

1. Zilla P, Brink J, Human P, Bezuidenhout D,. Prosthetic heart valves: catering for the few. Biomaterials 2008; 29: 385-406.
2. Sacks MS, David Merryman W, Schmidt DE,. On the biomechanics of heart valve function. J Biomech 2009; 42: 1804-1824.
3. Gabbay S, Kadam P, Factor S, Cheung TK,. Do heart valve bioprostheses degenerate for metabolic or mechanical reasons? J Thorac Cardiovasc Surg 1988; 95: 208-215.
4. Park CS, Park SS, Choi SY, Yoon SH, Kim WH, Kim YJ,. Anti alpha-gal immune response following porcine bioprosthesis implantation in children. J Heart Valve Dis 2010; 19: 124-130.
5. Schoen FJ, Levy RJ,. Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann Thorac Surg 2005; 79: 1072-1080.
6. Shields KJ, Stolz D, Watkins SC, Ahearn JM,. Complement proteins C3 and C4 bind to collagen and elastin in the vascular wall: a potential role in vascular stiffness and atherosclerosis. Clin Transl Sci 2011; 4: 146-152.
7. Friebe VM, Mikulis B, Kole S, Ruffing CS, Sacks MS, Vyavahare NR,. Neomycin enhances extracellular matrix stability of glutaraldehyde crosslinked bioprosthetic heart valves. J Biomed Mater Res B Appl Biomater 2011; 99: 217-229.
8. Shah SR, Vyavahare NR,. The effect of glycosaminoglycan stabilization on tissue buckling in bioprosthetic heart valves. Biomaterials 2008; 29: 1645-1653.
9. Scott JE, Stockwell RA,. Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid: implications in osteoarthrosis. J Physiol 2006; 574: 643-650.
10. Perumal S, Antipova O, Orgel JP,. Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis. Proc Natl Acad Sci USA 2008; 105: 2824-2829.
11. Konakci KZ, Bohle B, Blumer R, et al. Alpha-Gal on bioprostheses: xenograft immune response in cardiac surgery. Eur J Clin Invest 2005; 35: 17-23.
12. Bloch O, Golde P, Dohmen PM, Posner S, Konertz W, Erdbrügger W,. Immune response in patients receiving a bioprosthetic heart valve: lack of response with decellularized valves. Tissue Eng Part A 2011; 17: 2399-2405.
13. Galili U,. The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy. Immunol Cell Biol 2005; 83: 674-686.
14. Mangold A, Szerafin T, Hoetzenecker K, et al. Alpha-Gal specific IgG immune response after implantation of bioprostheses. Thorac Cardiovasc Surg 2009; 57: 191-195.
15. Rieben R, Bovin NV, Korchagina EY, et al. Xenotransplantation: in vitro analysis of synthetic alpha-galactosyl inhibitors of human anti-Galalpha1- >3Gal IgM and IgG antibodies. Glycobiology 2000; 10: 141-148.
16. Human P, Zilla P,. Inflammatory and immune processes: the neglected villain of bioprosthetic degeneration? J Long Term Eff Med Implants 2001; 11: 199-220.
17. Levy RJ, Schoen FJ, Levy JT, Nelson AC, Howard SL, Oshry LJ,. Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats. Am J Pathol 1983; 113: 143-155.
18. Schoen FJ, Levy RJ, Nelson AC, et al. Onset and progression of experimental bioprosthetic heart valve calcification. Lab Invest 1985; 52: 523-532.
19. Schoen FJ, Levy RJ, Nelson AC, Bernhard WF, Nashef A, Hawley M,. Calcification of bovine pericardium used in cardiac valve bioprostheses. Implications for the mechanisms of bioprosthetic tissue mineralization. Am J Pathol 1986; 123: 134-145.
20. Bailey MT, Pillarisetti S, Xiao H, Vyavahare NR,. Role of elastin in pathologic calcification of xenograft heart valves. J Biomed Mater Res A 2003; 66: 93-102.
21. Naso F, Gandaglia A, Iop L, Spina M, Gerosa G,. First quantitative assay of alpha-Gal in soft tissues: presence and distribution of the epitope before and after cell removal from xenogeneic heart valves. Acta Biomater 2011; 7: 1728-1734.
22. Naso F, Gandaglia A, Iop L, Spina M, Gerosa G,. Alpha-Gal detectors in xenotransplantation research: a word of caution. Xenotransplantation 2012; 19: 215-220.
23. Galili U, Latemple DC, Radic MZ,. A sensitive assay for measuring alpha-Gal epitope expression on cells by a monoclonal anti-Gal antibody. Transplantation 1998; 65: 1129-1132.
24. Lagutina I, Lazzari G, Galli C,. Birth of clone pigs from zona-free nuclear transfer embryos developed in vitro to blastocyst before transfer. Cloning Stem Cells 2006; 8: 283-293.
25. Nottle MB, Beebe LF, Harrison SJ, et al. Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation 2007; 14: 339-344.
26. Harrison SJ, Guidolin A, Faast R, et al. Efficient generation of alpha(1,3) galactosyltransferase knockout porcine fetal fibroblasts for nuclear transfer. Transgenic Res 2002; 11: 143-150.
27. Stacchino C, Bona G, Bonetti F, Rinaldi S, Della CL, Grignani A,. Detoxification process for glutaraldehyde-treated bovine pericardium: biological, chemical and mechanical characterization. J Heart Valve Dis 1998; 7: 190-194.
28. Munnelly AE, Cochrane L, Leong J, Vyavahare NR,. Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves. Biomaterials 2012; 33: 1-8.
29. Weber K, Rathke PC, Osborn M,. Cytoplasmatic microtubular images in glutaraldehyde-fixed tissue culture cells by electron microscopy and by immunofluorescence microscopy. Proc Natl Acad Sci USA 1978; 75: 1820-1824.
30. Cande WZ, Lazarides E, McIntosh JR,. A comparison of the distribution of actin and tubulin in the mammalian mitotic spindle as seen by indirect immunofluorescence. J Cell Biol 1977; 72: 552-567.
31. Mével-Ninio M, Weiss MC,. Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids. J Cell Biol 1981; 90: 339-350.
32. Newman GR, Jasani B, Williams ED,. A simple post-embedding system for the rapid demonstration of tissue antigens under the electron microscope. Histochem J 1983; 15: 543-555.
33. Adams JC,. Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J Histochem Cytochem 1992; 40: 1457-1463.
34. Bubbers JE, Henney CS,. Studies on the synthetic capacity and antigenic expression of glutaraldehyde-fixed target cells. J Immunol 1975; 114: 1126-1131.
35. Ikegaki N, Kennett RH,. Glutaraldehyde fixation of the primary antibody-antigen complex on nitrocellulose paper increases the overall sensitivity of immunoblot assay. J Immunol Methods 1989; 124: 205-210.
36. Lila N, McGregor CG, Carpentier S, Rancic J, Byrne GW, Carpentier A,. Gal knockout pig pericardium: new source of material for heart valve bioprostheses. J Heart Lung Transplant 2010; 29: 538-543.
37. Valfrè C, Ius P, Minniti G, et al. The fate of Hancock II porcine valve recipients 25 years after implant. Eur J Cardiothorac Surg 2010; 38: 141-146.
38. Wiebe D, Megerman J, L'Italien GJ, Abbott WM,. Glutaraldehyde release from vascular prostheses of biologic origin. Surgery 1988; 104: 26-33.
39. Webb CL, Schoen FJ, Levy RJ,. Covalent binding of aminopropanehydroxydiphosphonate to glutaraldehyde residues in pericardial bioprosthetic tissue: stability and calcification inhibition studies. Exp Mol Pathol 1989; 50: 291-302.
40. Huang-Lee LL, Cheung DT, Nimni ME,. Biochemical changes and cytotoxicity associated with the degradation of polymeric glutaraldehyde derived crosslinks. J Biomed Mater Res 1990; 24: 1185-1201.
41. Peters K, Richards FM,. Chemical cross-linking reagents and problems in studies of membrane structure. Ann Rev Biochem 1977; 46: 523-551.
42. Lutz AJ, Li P, Estrada JL, Sidner RA, et al. Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation 2013; 20: 27-35.
43. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298.
44. Diaz SL, Padler-Karavani V, Ghaderi D, et al. Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS ONE 2009; 4: e4241.
45. Padler-Karavani V, Yu H, Cao H, Chokhawala H, et al. Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology 2008; 18: 818-830.