Are prophylactic antifungals in highly colonized patients safe and effective?

Intensive Care Medicine

Volumn 41, Issue 7, 2015, Pages 1336-1339

  Bassetti, Matteo ^a   Leon, Cristobal ^b   Timsit, Jean Francois ^c,d  

^a SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^b HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITÉ PARIS DIDEROT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANIDULAFUNGIN; ANTIFUNGAL AGENT; CASPOFUNGIN; FLUCONAZOLE; MICAFUNGIN;

APACHE; CANDIDEMIA; CRITICALLY ILL PATIENT; EDITORIAL; FUNGAL COLONIZATION; HUMAN; INFECTION RISK; INTENSIVE CARE UNIT; INTRAVASCULAR CATHETER; INVASIVE CANDIDIASIS; MORTALITY; OBSERVATIONAL STUDY; PARENTERAL NUTRITION; PATIENT SAFETY; PRACTICE GUIDELINE; PROPHYLAXIS; CANDIDA; CANDIDIASIS; CRITICAL ILLNESS; FEMALE; ISOLATION AND PURIFICATION; MALE;

ANTIFUNGAL AGENTS; CANDIDA; CANDIDIASIS; CRITICAL ILLNESS; FEMALE; FLUCONAZOLE; HUMANS; MALE;

EID: 84933280537     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-3888-9     Document Type: Editorial

References (18)

1. Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr et al (2009) Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 48:503–535
2. Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O et al (2012) ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect 18(Suppl 7):19–37
3. Zaoutis TE, Argon J, Chu J, Berlin JA, Walsh TJ, Feudtner C (2005) The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis 41:1232–1239
4. Leroy O, Gangneux JP, Montravers P, Mira JP, Gouin F, Sollet JP et al (2009) Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005–2006). Crit Care Med 37:1612–1618
5. Leon C, Ostrosky-Zeichner L, Schuster M (2014) What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients. Intensive Care Med 40:808–819
6. Bassetti M, Molinari MP, Mussap M, Viscoli C, Righi E (2013) Candidaemia in internal medicine departments: the burden of a rising problem. Clin Microbiol Infect 19:E281–E284
7. Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R (1994) Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg 220:751–758
8. Garbino J, Lew DP, Romand JA, Hugonnet S, Auckenthaler R, Pittet D (2002) Prevention of severe Candida infections in nonneutropenic, high-risk, critically ill patients: a randomized, double-blind, placebo-controlled trial in patients treated by selective digestive decontamination. Intensive Care Med 28:1708–1717
9. Shorr AF, Chung K, Jackson WL, Waterman PE, Kollef MH (2005) Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis. Crit Care Med 33:1928–1935
10. Albert M, Williamson D, Muscedere J, Lauzier F, Rotstein C, Kanji S, Jiang X, Hall M, Heyland D (2014) Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med 40:1313–1322
11. Ostrosky-Zeichner L, Shoham S, Vazquez J et al (2014) MSG-01: a randomized, double-blind, placebo-controlled trial of caspofungin prophylaxis followed by preemptive therapy for invasive candidiasis in high-risk adults in the critical care setting. Clin Infect Dis 58:1219–1226
12. Ferreira D, Grenouillet F, Blasco G, Samain E, Hénon T, Dussaucy A, Millon L, Mercier M, Pili-Floury S (2015) Outcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization. Intensive Care Med. doi:10.1007/s00134-015-3791-4
13. Fournier P, Schwebel C, Maubon D, Vesin A, Lebeau B, Foroni L, Hamidfar-Roy R, Cornet M, Timsit JF, Pelloux H (2011) Antifungal use influences Candida species distribution and susceptibility in the intensive care unit. J Antimicrob Chemother 66(12):2880–2886
14. Bassetti M, Righi E, Costa A, Fasce R, Molinari MP, Rosso R et al (2006) Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis 6:21
15. Morrell M, Fraser VJ, Kollef MH (2005) Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother 49:3640–3645
16. Bassetti M, Righi E, Ansaldi F, Merelli M, Trucchi C, De Pascale G, Diaz-Martin A, Luzzati R, Rosin C, Lagunes L et al (2014) A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med 40:839–845
17. Eggimann P, Bille J, Marchetti O (2011) Diagnosis of invasive candidiasis in the ICU. Ann Intensive Care 1:37
18. Clancy CL, Nguyen MH (2014) Undiagnosed invasive candidiasis: incorporating non-culture diagnostics into rational prophylactic and preemptive antifungal strategies. Expert Rev Anti Infect Therapy 12:731–734