Undiagnosed invasive candidiasis: Incorporating non-culture diagnostics into rational prophylactic and preemptive antifungal strategies

Expert Review of Anti-Infective Therapy

Volumn 12, Issue 7, 2014, Pages 731-734

  Clancy, Cornelius J ^a   Nguyen, Minh Hong ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Anti mannan antibody; Candida; Candidemia; Candidiasis; Deep seated candidiasis; Fungitell; Intra abdominal candidiasis; Mannan; D glucan

Indexed keywords

ANTIFUNGAL AGENT; BETA GLUCAN; MANNAN; MANNAN ANTIBODY; UNCLASSIFIED DRUG;

ANTIBIOTIC PROPHYLAXIS; BLOOD CULTURE; DIAGNOSTIC TEST; FUNGAL CELL WALL; FUNGAL DETECTION; FUNGUS CULTURE; HIGH RISK PATIENT; INFECTION RISK; INTENSIVE CARE UNIT; INTERMEDIATE RISK PATIENT; INTERMETHOD COMPARISON; INVASIVE CANDIDIASIS; LIMIT OF DETECTION; LOW RISK PATIENT; MICROBIOLOGY TEST; NONHUMAN; PREDICTIVE VALUE; REVIEW; SENSITIVITY AND SPECIFICITY; TREATMENT INDICATION; CANDIDIASIS, INVASIVE; HUMAN; MICROBIOLOGICAL EXAMINATION;

ANTIFUNGAL AGENTS; CANDIDIASIS, INVASIVE; HUMANS; MYCOLOGICAL TYPING TECHNIQUES; SENSITIVITY AND SPECIFICITY;

EID: 84902492774     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.2014.919853     Document Type: Review

References (22)

1. Andes DR, Safdar N, Baddley JW, et al. Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin Infect Dis 2012;54(8):1110-22
2. Clancy CJ, Nguyen MH. The end of an era in defining the optimal treatment of invasive candidiasis. Clin Infect Dis 2012; 54(8):1123-5
3. Clancy CJ, Nguyen MH. Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis 2013;56(9):1284-92
4. Ostrosky-Zeichner L, Shoham S, Vazquez J, et al. Msg-01: a randomized, double-blind, placebo-controlled trial of caspofungin prophylaxis followed by preemptive therapy for invasive candidiasis in high-risk adults in the critical care setting. Clin Infect Dis 2014;58(9):1219-26
5. Wheat LJ. Approach to the diagnosis of invasive aspergillosis and candidiasis. Clin Chest Med 2009;30(2):367-77.viii
6. Pfeiffer CD, Samsa GP, Schell WA, et al. Quantitation of Candida CFU in initial positive blood cultures. J Clin Microbiol 2011;49(8):2879-83
7. Schell WA, Benton JL, Smith PB, et al. Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood. Eur J Clin Microbiol Infect Dis 2012;31(9):2237-45
8. Ericson EL, Klingspor L, Ullberg M, et al. Clinical comparison of the bactec mycosis ic/f, bact/alert fa, and bact/alert fn blood culture vials for the detection of candidemia. Diagn Microbiol Infect Dis 2012;73(2):153-6
9. Karageorgopoulos DE, Vouloumanou EK, Ntziora F, et al. Beta-d-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis. Clin Infect Dis 2011;52(6): 750-70
10. Lu Y, Chen YQ, Guo YL, et al. Diagnosis of invasive fungal disease using serum (1-3)-beta-d-glucan: a bivariate meta-analysis. Intern Med 2011;50(22):2783-91
11. Mikulska M, Calandra T, Sanguinetti M, et al. The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on infections in leukemia. Crit Care 2010; 14(6):R222
12. Kasai M, Francesconi A, Petraitiene R, et al. Use of quantitative real-time PCR to study the kinetics of extracellular DNA released from Candida albicans, with implications for diagnosis of invasive candidiasis. J Clin Microbiol 2006;44(1):143-50
13. Nguyen MH, Wissel MC, Shields RK, et al. Performance of Candida real-time polymerase chain reaction, beta-d-glucan assay, and blood cultures in the diagnosis of invasive candidiasis. Clin infect dis 2012; 54(9):1240-8
14. Tissot F, Lamoth F, Hauser PM, et al. Beta-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Am J Respir Crit Care Med 2013;188(9):1100-9
15. Ostrosky-Zeichner L, Sable C, Sobel J, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis 2007;26(4):271-6
16. Kett DH, Azoulay E, Echeverria PM, et al. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med 2011;39(4):665-70
17. Playford EG, Webster AC, Sorrell TC, et al. Antifungal agents for preventing fungal infections in non-neutropenic critically ill and surgical patients: systematic review and meta-analysis of randomized clinical trials. J Antimicrob Chemother 2006;57(4):628-38
18. Shorr AF, Chung K, Jackson WL, et al. Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis. Crit Care Med 2005;33(9):1928-35.quiz 1936
19. Eggimann P, Francioli P, Bille J, et al. Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients. Crit Care Med 1999; 27(6):1066-72
20. Garbino J, Lew DP, Romand JA, et al. Prevention of severe Candida infections in nonneutropenic, high-risk, critically ill patients: a randomized, double-blind, placebo-controlled trial in patients treated by selective digestive decontamination. Intensive Care Med 2002;28(12):1708-17
21. Pelz RK, Hendrix CW, Swoboda SM, et al. Double-blind placebo-controlled trial of fluconazole to prevent Candidal infections in critically ill surgical patients. Ann Surg 2001;233(4):542-8
22. Bassetti M, Marchetti M, Chakrabarti A, et al. A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med 2013;39(12):2092-106