IFT46 plays an essential role in cilia development

Developmental Biology

Volumn 400, Issue 2, 2015, Pages 248-257

  Lee, Mi Sun ^a   Hwang, Kyu Seok ^a   Oh, Hyun Woo ^b   Ji Ae, Kim ^b   Kim, Hyun Taek ^a   Cho, Hyun Soo ^b   Lee, Jeong Ju ^b   Yeong Ko, Je ^c   Choi, Jung Hwa ^a   Jeong, Yun Mi ^a   You, Kwan Hee ^a   Kim, Joon ^d   Park, Doo Sang ^b   Nam, Ki Hoan ^b   Aizawa, Shinichi ^e   Kiyonari, Hiroshi ^e   Shioi, Go ^e   Park, Jong Hoon ^c   Zhou, Weibin ^f   Kim, Nam Soon ^b   Kim, Cheol Hee ^a   more..

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Sookmyung Women's University   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^e RIKEN Center for Biosystems Dynamics Research   (Japan)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cilia; Ciliopathy; IFT; IFT46; Intraflagellar transport; KO mouse; L R defect; Zebrafish

Indexed keywords

MEMBRANE PROTEIN; PROTEIN IFT46; UNCLASSIFIED DRUG; IFT46 PROTEIN, MOUSE; IFT46 PROTEIN, ZEBRAFISH; SIGNAL PEPTIDE; ZEBRAFISH PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; CELL VACUOLE; CILIATED EPITHELIUM CELL; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; EXPRESSED SEQUENCE TAG; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENE SILENCING; IFT46 GENE; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; ZEBRA FISH; AMINO ACID SEQUENCE; ANIMAL; EMBRYOLOGY; EUKARYOTIC FLAGELLUM; GENETICS; HUMAN; KINETOSOME; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

DANIO RERIO; MUS; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; BASAL BODIES; CILIA; GENE EXPRESSION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84933182187     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2015.02.009     Document Type: Article

References (47)

1. Badano J., Mitsuma N., Beales P., Katsanis N. The ciliopathies: an emerging class of human genetic disorders. Annu. Rev. Genomics Hum. Genet. 2006, 7:125-148.
2. Ben J., Elworthy S., Ng A.S., van Eeden F., Ingham P.W. Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development 2011, 138:4969-4978.
3. Cho S., Kim S., Kim J., Kim J.-S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 2013, 31:230-232.
4. Cole D., Snell W. SnapShot: intraflagellar transport. Cell 2009, 137. 784-784.e1.
5. Delaval B., Bright A., Lawson N., Doxsey S. The cilia protein IFT88 is required for spindle orientation in mitosis. Nat. Cell Biol. 2011, 13:461-468.
6. Eggenschwiler J., Anderson K. Cilia and developmental signaling. Annu. Rev. Cell Dev. Biol. 2007, 23:345-373.
7. Essner J., Amack J., Nyholm M., Harris E., Yost H. Kupffer[U+05F3]s vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 2005, 132:1247-1260.
8. Fliegauf M., Benzing T., Omran H. When cilia go bad: cilia defects and ciliopathies. Nat. Rev. Mol. Cell Biol. 2007, 8:880-893.
9. Follit J.A., Xu F., Keady B.T., Pazour G.J. Characterization of mouse IFT complex B. Cell Motil. Cytoskelet. 2009, 66:457-468.
10. Gerdes J., Davis E., Katsanis N. The vertebrate primary cilium in development, homeostasis, and disease. Cell 2009, 137:32-45.
11. Goetz S., Anderson K. The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet. 2010, 11:331-344.
12. Gorivodsky M., Mukhopadhyay M., Wilsch-Braeuninger M., Phillips M., Teufel A., Kim C., Malik N., Huttner W., Westphal H. Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev. Biol. 2009, 325:24-32.
13. Gouttenoire J., Valcourt U., Bougault C., Aubert-Foucher E., Arnaud E., Giraud L., Mallein-Gerin F. Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. J. Biol. Chem. 2007, 282:30960-30973.
14. Hamada H., Meno C., Watanabe D., Saijoh Y. Establishment of vertebrate left-right asymmetry. Nat. Rev. Genet. 2002, 3:103-113.
15. Hildebrandt F., Otto E. Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?. Nat. Rev. Genet. 2005, 6:928-940.
16. Hirokawa N., Tanaka Y., Okada Y. Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow. Cold Spring Harb. Perspect. Biol. 2009, 1:a000802.
17. Hou Y., Qin H., Follit J., Pazour G., Rosenbaum J., Witman G. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. J. Cell Biol. 2007, 176:653-665.
18. Huang P, Schier AF. Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 2009, 136:3089-3098.
19. Houde C., Dickinson R., Houtzager V., Cullum R., Montpetit R., Metzler M., Simpson E., Roy S., Hayden M., Hoodless P., Nicholson D. Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev. Biol. 2006, 300:523-533.
20. Kishimoto N., Cao Y., Park A., Sun Z. Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 2008, 14:954-961.
21. Kramer-Zucker A., Olale F., Haycraft C., Yoder B., Schier A., Drummond I. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer[U+05F3]s vesicle is required for normal organogenesis. Development 2005, 132:1907-1921.
22. Kreiling J., Williams G., Creton R. Analysis of Kupffer[U+05F3]s vesicle in zebrafish embryos using a cave automated virtual environment. Dev. Dyn. 2007, 236:1963-1969.
23. Kunitomo H., Iino Y. Caenorhabditis elegans DYF-11, an orthologue of mammalian Traf3ip1/MIP-T3, is required for sensory cilia formation. Genes Cells 2008, 13:13-25.
24. Lenhart K., Lin S.-Y., Titus T., Postlethwait J., Burdine R. Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 2011, 138:4405-4410.
25. Lucker B., Miller M., Dziedzic S., Blackmarr P., Cole D. Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46. J. Biol. Chem. 2010, 285:21508-21518.
26. Lunt S.C., Haynes T., Perkins B.D. Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Dev. Dyn. 2009, 238:1744-1759.
27. Murcia N., Richards W., Yoder B., Mucenski M., Dunlap J., Woychik R. The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 2000, 127:2347-2355.
28. Nigg E., Raff J. Centrioles, centrosomes, and cilia in health and disease. Cell 2009, 139:663-678.
29. Novarino G., Akizu N., Gleeson J. Modeling human disease in humans: the ciliopathies. Cell 2011, 147:70-79.
30. Oteíza P., Köppen M., Concha M., Heisenberg C.-P. Origin and shaping of the laterality organ in zebrafish. Development 2008, 135:2807-2813.
31. Pazour G., Rosenbaum J. Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol. 2002, 12:551-555.
32. Pazour G. Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J. Am. Soc. Nephrol. 2004, 15:2528-2536.
33. Raya A., Izpisúa, Belmonte J. Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nat. Rev. Genet. 2006, 7:283-293.
34. Richey E., Qin H. Dissecting the sequential assembly and localization of intraflagellar transport particle complex B in Chlamydomonas. PLoS One 2012, 7:e43118.
35. Robert A., Margall-Ducos G., Guidotti J.E., Brégerie O., Celati C., Bréchot C., Desdouets C. The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells. J. Cell Sci. 2007, 120:628-637.
36. Rosenbaum J., Witman G. Intraflagellar transport. Nat. Rev. Mol. Cell Biol. 2002, 3:813-825.
37. Silverman M., Leroux M. Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Trends Cell Biol. 2009, 19:306-316.
38. Scholey J. Intraflagellar transport. Annu. Rev. Cell Dev. Biol. 2003, 19:423-443.
39. Stooke-Vaughan G., Huang P., Hammond K., Schier A., Whitfield T. The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development 2012, 139:1777-1787.
40. Sukumaran S., Perkins B. Early defects in photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 Intraflagellar Transport mutants. Vis. Res. 2009, 49:479-489.
41. Sullivan-Brown J., Schottenfeld J., Okabe N., Hostetter C., Serluca F., Thiberge S., Burdine R. Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. Dev. Biol. 2008, 314:261-275.
42. Sung Y., Kim J., Kim H.-T., Lee J., Jeon J., Jin Y., Choi J-H., Ban Y., Ha S.-J., Kim C.-H., Lee H.-W., Kim J.-S. Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome Res. 2014, 24:125-131.
43. Taulman P., Haycraft C., Balkovetz D., Yoder B. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol. Biol. Cell 2001, 12:589-599.
44. Tsujikawa M., Malicki J. Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron 2004, 42:703-716.
45. Wood C., Wang Z., Diener D., Zones J., Rosenbaum J., Umen J. IFT proteins accumulate during cell division and localize to the cleavage furrow in Chlamydomonas. PLoS One 2012, 7:e30729.
46. Zariwala M., Knowles M., Omran H. Genetic defects in ciliary structure and function. Annu. Rev. Physiol. 2007, 69:423-450.
47. Zhao C., Malicki J. Genetic defects of pronephric cilia in zebrafish. Mech. Dev. 2007, 124:605-616.