Changes in cytokines and aggrecan ARGS neoepitope in synovial fluid and serum and in C-terminal crosslinking telopeptide of type II collagen and N-terminal crosslinking telopeptide of type i collagen in urine over five years after anterior cruciate ligament rupture: An exploratory analysis in the knee anterior cruciate ligament, nonsurgical versus surgical treatment trial

Arthritis and Rheumatology

Volumn 67, Issue 7, 2015, Pages 1816-1825

  Struglics, André ^a   Larsson, Staffan ^a   Kumahashi, Nobuyuki ^a,b   Frobell, Richard ^a   Lohmander, L Stefan ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AMINO TERMINAL TELOPEPTIDE; ARGININE; BIOLOGICAL MARKER; CARBOXY TERMINAL CROSSLINKING TELOPEPTIDE OF TYPE II COLLAGEN; CARBOXY TERMINAL TELOPEPTIDE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; C-TERMINAL CROSS-LINKING TELOPEPTIDE OF TYPE II COLLAGEN, HUMAN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; EPITOPE; PEPTIDE; PEPTIDE FRAGMENT;

ADULT; ANTERIOR CRUCIATE LIGAMENT RUPTURE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPLORATORY RESEARCH; FEMALE; HUMAN; KIDNEY CONCENTRATING CAPACITY; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); STATISTICAL SIGNIFICANCE; SYNOVIAL FLUID; URINALYSIS; ANTERIOR CRUCIATE LIGAMENT; CASE CONTROL STUDY; HOMEOSTASIS; INJURIES; LONGITUDINAL STUDY; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PHYSIOLOGY; RISK FACTOR; RUPTURE; SYNOVIUM; TIME; URINE;

ADULT; AGGRECANS; ANTERIOR CRUCIATE LIGAMENT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COLLAGEN TYPE I; COLLAGEN TYPE II; CYTOKINES; EPITOPES; FEMALE; HOMEOSTASIS; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PEPTIDE FRAGMENTS; PEPTIDES; PROSPECTIVE STUDIES; RISK FACTORS; RUPTURE; SYNOVIAL MEMBRANE; TIME FACTORS;

EID: 84933073422     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39146     Document Type: Article

References (50)

1. Lohmander LS, Englund PM, Dahl LL, Roos EM., The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 2007; 35: 1756-69.
2. Sandy JD, Flannery CR, Neame PJ, Lohmander LS., The structure of aggrecan fragments in human synovial fluid: evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J Clin Invest 1992; 89: 1512-6.
3. Lohmander LS, Hoerrner LA, Lark MW., Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis. Arthritis Rheum 1993; 36: 181-9.
4. Lohmander LS, Atley LM, Pietka TA, Eyre DR., The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 2003; 48: 3130-9.
5. Goldring MB., The role of the chondrocyte in osteoarthritis [review]. Arthritis Rheum 2000; 43: 1916-26.
6. Lohmander LS, Dahlberg L, Ryd L, Heinegard D. Increased levels of proteoglycan fragments in knee joint fluid after injury. Arthritis Rheum 1989; 32: 1434-42.
7. Lohmander LS, Hoerrner LA, Dahlberg L, Roos H, Bjornsson S, Lark MW., Stromelysin, tissue inhibitor of metalloproteinases and proteoglycan fragments in human knee joint fluid after injury. J Rheumatol 1993; 20: 1362-8.
8. Cameron M, Buchgraber A, Passler H, Vogt M, Thonar E, Fu F, et al., The natural history of the anterior cruciate ligament-deficient knee: changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med 1997; 25: 751-4.
9. Lohmander LS, Ionescu M, Jugessur H, Poole AR., Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum 1999; 42: 534-44.
10. Irie K, Uchiyama E, Iwaso H., Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee. Knee 2003; 10: 93-6.
11. Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, et al., Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 2008; 58: 1707-15.
12. Larsson S, Lohmander LS, Struglics A., Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study. Arthritis Res Ther 2009; 11: R92.
13. Struglics A, Hansson M, Lohmander LS., Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains. Osteoarthritis Cartilage 2011; 19: 1047-57.
14. Sward P, Frobell R, Englund M, Roos H, Struglics A., Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis): a cross-sectional analysis. Osteoarthritis Cartilage 2012; 20: 1302-8.
15. Dahlberg L, Friden T, Roos H, Lark MW, Lohmander LS., A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture: synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1. Br J Rheumatol 1994; 33: 1107-11.
16. Larsson S, Englund M, Struglics A, Lohmander LS., The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study. Osteoarthritis Cartilage 2012; 20: 388-95.
17. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E., Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 2001; 60: 619-26.
18. Reijman M, Hazes JM, Bierma-Zeinstra SM, Koes BW, Christgau S, Christiansen C, et al., A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 2004; 50: 2471-8.
19. Jordan KM, Syddall HE, Garnero P, Gineyts E, Dennison EM, Sayer AA, et al., Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men. Ann Rheum Dis 2006; 65: 871-7.
20. Ishijima M, Watari T, Naito K, Kaneko H, Futami I, Yoshimura-Ishida K, et al., Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 2011; 13: R22.
21. Chmielewski TL, Trumble TN, Joseph AM, Shuster J, Indelicato PA, Moser MW, et al., Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction. Osteoarthritis Cartilage 2012; 20: 1294-301.
22. Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al., Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 2011; 19: 515-42.
23. Frobell RB, Roos EM, Roos HP, Ranstam J, Lohmander LS., A randomized trial of treatment for acute anterior cruciate ligament tears. N Engl J Med 2010; 363: 331-42.
24. Frobell RB, Roos HP, Roos EM, Roemer FW, Ranstam J, Lohmander LS., Treatment for acute anterior cruciate ligament tear: five year outcome of randomised trial. BMJ 2013; 346: f232.
25. Larsson S, Lohmander LS, Struglics A., An ARGS-aggrecan assay for analysis in blood and synovial fluid. Osteoarthritis Cartilage 2014; 22: 242-9.
26. Pratta MA, Su JL, Leesnitzer MA, Struglics A, Larsson S, Lohmander LS, et al., Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments. Osteoarthritis Cartilage 2006; 14: 702-13.
27. Higuchi H, Shirakura K, Kimura M, Terauchi M, Shinozaki T, Watanabe H, et al., Changes in biochemical parameters after anterior cruciate ligament injury. Int Orthop 2006; 30: 43-7.
28. Bigoni M, Sacerdote P, Turati M, Franchi S, Gandolla M, Gaddi D, et al., Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury. J Orthop Res 2013; 31: 315-21.
29. Beekhuizen M, Gierman LM, van Spil WE, Van Osch GJ, Huizinga TW, Saris DB, et al., An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid. Osteoarthritis Cartilage 2013; 21: 918-22.
30. Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, et al., Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum 2013; 65: 1547-60.
31. Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan M, Ferguson C, et al., Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. PLoS One 2013; 8: e54633.
32. Hellio Le Graverand MP, Eggerer J, Sciore P, Reno C, Vignon E, Otterness I, et al., Matrix metalloproteinase-13 expression in rabbit knee joint connective tissues: influence of maturation and response to injury. Matrix Biol 2000; 19: 431-41.
33. Lee JH, Fitzgerald JB, Dimicco MA, Cheng DM, Flannery CR, Sandy JD, et al., Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. Arch Biochem Biophys 2009; 489: 118-26.
34. Stevens AL, Wishnok JS, White FM, Grodzinsky AJ, Tannenbaum SR., Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Proteomics 2009; 8: 1475-89.
35. Van Spil WE, Drossaers-Bakker KW, Lafeber FP., Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis. Ann Rheum Dis 2013; 72: 29-36.
36. Mouritzen U, Christgau S, Lehmann HJ, Tanko LB, Christiansen C., Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 2003; 62: 332-6.
37. Sone T, Miyake M, Takeda N, Fukunaga M., Urinary excretion of type I collagen crosslinked N-telopeptides in healthy Japanese adults: age- and sex-related changes and reference limits. Bone 1995; 17: 335-9.
38. Schulze-Tanzil G, Zreiqat H, Sabat R, Kohl B, Halder A, Muller RD, et al., Interleukin-10 and articular cartilage: experimental therapeutical approaches in cartilage disorders. Curr Gene Ther 2009; 9: 306-15.
39. Dingle JT, Page Thomas DP, King B, Bard DR., In vivo studies of articular tissue damage mediated by catabolin/interleukin 1. Ann Rheum Dis 1987; 46: 527-33.
40. Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, et al., Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther 2012; 14: R7.
41. Wassilew GI, Lehnigk U, Duda GN, Taylor WR, Matziolis G, Dynybil C., The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy 2010; 26: 1096-104.
42. Marks PH, Donaldson ML., Inflammatory cytokine profiles associated with chondral damage in the anterior cruciate ligament-deficient knee. Arthroscopy 2005; 21: 1342-7.
43. Sward P, Struglics A, Englund M, Roos HP, Frobell RB., Soft tissue knee injury with concomitant osteochondral fracture is associated with higher degree of acute joint inflammation. Am J Sports Med 2014; 42: 1096-102.
44. Elsaid KA, Machan JT, Waller K, Fleming BC, Jay GD., The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor α on chondroprotection in an animal model. Arthritis Rheum 2009; 60: 2997-3006.
45. Kraus VB, Birmingham J, Stabler TV, Feng S, Taylor DC, Moorman CT III, et al., Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthritis Cartilage 2012; 20: 271-8.
46. Simkin PA., Assessing biomarkers in synovial fluid: consider the kinetics of clearance. Osteoarthritis Cartilage 2013; 21: 7-9.
47. Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA, et al., Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res 2011; 29: 802-9.
48. Chubinskaya S, Wimmer MA., Key pathways to prevent posttraumatic arthritis for future molecule-based therapy. Cartilage 2013; 4 Suppl 3: 13S-21S.
49. Eckstein F, Wirth W, Lohmander LS, Hudelmaier MI, Frobell RB., Five-year followup of knee joint cartilage thickness changes after acute rupture of the anterior cruciate ligament. Arthritis Rheumatol 2015; 67: 152-61.
50. Hunter DJ, Lohmander LS, Makovey J, Tamez-Pena J, Totterman S, Schreyer E, et al., The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial. Osteoarthritis Cartilage 2014; 22: 959-68.