Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction

Osteoarthritis and Cartilage

Volumn 20, Issue 11, 2012, Pages 1294-1301

  Chmielewski, T L ^a   Trumble, T N ^b   Joseph, A M ^a   Shuster, J ^a   Indelicato, P A ^c   Moser, M W ^a   Cicuttini, F M ^d   Leeuwenburgh, C ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Anterior cruciate ligament; Biomarker; Knee; Pain; Rehabilitation

Indexed keywords

COLLAGEN TYPE 2;

ADULT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTERNATIONAL KNEE DOCUMENTATION COMMITTEE SUBJECTIVE KNEE FORM; KNEE FUNCTION; KNEE OSTEOARTHRITIS; KNEE PAIN; MALE; NUMERIC PAIN RATING SCALE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN URINE LEVEL; RATING SCALE; STATISTICAL SIGNIFICANCE; URINALYSIS;

ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; COLLAGEN TYPE II; FEMALE; HUMANS; KNEE INJURIES; KNEE JOINT; MALE; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; PEPTIDE FRAGMENTS; POSTOPERATIVE COMPLICATIONS; RECOVERY OF FUNCTION; YOUNG ADULT;

EID: 84866454231     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.07.014     Document Type: Article

References (40)

1. Griffin L.Y., Agel J., Albohm M.J., Arendt E.A., Dick R.W., Garrett W.E., et al. Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies. J Am Acad Orthop Surg 2000, 8:141-150.
2. Beynnon B.D., Johnson R.J., Abate J.A., Fleming B.C., Nichols C.E. Treatment of anterior cruciate ligament injuries, part I. Am J Sports Med 2005, 33:1579-1602.
3. Bradley J.P., Klimkiewicz J.J., Rytel M.J., Powell J.W. Anterior cruciate ligament injuries in the National Football League: epidemiology and current treatment trends among team physicians. Arthroscopy 2002, 18:502-509.
4. Lohmander L.S., Ostenberg A., Englund M., Roos H. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum 2004, 50:3145-3152.
5. Kessler M.A., Behrend H., Henz S., Stutz G., Rukavina A., Kuster M.S. Function, osteoarthritis and activity after ACL-rupture: 11 years follow-up results of conservative versus reconstructive treatment. Knee Surg Sports Traumatol Arthrosc 2008, 16:442-448.
6. Hui C., Salmon L.J., Kok A., Maeno S., Linklater J., Pinczewski L.A. Fifteen-year outcome of endoscopic anterior cruciate ligament reconstruction with patellar tendon autograft for "isolated" anterior cruciate ligament tear. Am J Sports Med 2011, 39:89-98.
7. Meunier A., Odensten M., Good L. Long-term results after primary repair or non-surgical treatment of anterior cruciate ligament rupture: a randomized study with a 15-year follow-up. Scand J Med Sci Sports 2007, 17:230-237.
8. Andersson D., Samuelsson K., Karlsson J. Treatment of anterior cruciate ligament injuries with special reference to surgical technique and rehabilitation: an assessment of randomized controlled trials. Arthroscopy 2009, 25:653-685.
9. Oiestad B.E., Holm I., Aune A.K., Gunderson R., Myklebust G., Engebretsen L., et al. Knee function and prevalence of knee osteoarthritis after anterior cruciate ligament reconstruction: a prospective study with 10 to 15 years of follow-up. Am J Sports Med 2010, 38:2201-2210.
10. Hurd W.J., Axe M.J., Snyder-Mackler L. A 10-year prospective trial of a patient management algorithm and screening examination for highly active individuals with anterior cruciate ligament injury: part 1, outcomes. Am J Sports Med 2008, 36:40-47.
11. Oiestad B.E., Holm I., Engebretsen L., Risberg M.A. The association between radiographic knee osteoarthritis and knee symptoms, function and quality of life 10-15 years after anterior cruciate ligament reconstruction. Br J Sports Med 2011, 45:583-588.
12. Goldring M.B., Goldring S.R. Osteoarthritis. J Cell Physiol 2007, 213:626-634.
13. De Ceuninck F., Sabatini M., Pastoureau P. Recent progress toward biomarker identification in osteoarthritis. Drug Discov Today 2011, 16:443-449.
14. Garnero P., Piperno M., Gineyts E., Christgau S., Delmas P.D., Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 2001, 60:619-626.
15. Dam E.B., Byrjalsen I., Karsdal M.A., Qvist P., Christiansen C. Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI. Osteoarthritis Cartilage 2009, 17:384-389.
16. Garnero P., Ayral X., Rousseau J.C., Christgau S., Sandell L.J., Dougados M., et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum 2002, 46:2613-2624.
17. Cibere J., Zhang H., Garnero P., Poole A.R., Lobanok T., Saxne T., et al. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum 2009, 60:1372-1380.
18. Jordan K.M., Syddall H.E., Garnero P., Gineyts E., Dennison E.M., Sayer A.A., et al. Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men. Ann Rheum Dis 2006, 65:871-877.
19. Karsdal M.A., Byrjalsen I., Bay-Jensen A.C., Henriksen K., Riis B.J., Christiansen C. Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation. BMC Musculoskelet Disord 2010, 11:125.
20. Tanishi N., Yamagiwa H., Hayami T., Mera H., Koga Y., Omori G., et al. Relationship between radiological knee osteoarthritis and biochemical markers of cartilage and bone degradation (urine CTX-II and NTX-I): the Matsudai Knee Osteoarthritis Survey. J Bone Miner Metab 2009, 27:605-612.
21. Bruyere O., Collette J., Kothari M., Zaim S., White D., Genant H., et al. Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study. Ann Rheum Dis 2006, 65:1050-1054.
22. Sharif M., Kirwan J., Charni N., Sandell L.J., Whittles C., Garnero P. A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis - association with disease progression. Rheumatology (Oxford) 2007, 46:938-943.
23. Sowers M.F., Karvonen-Gutierrez C.A., Yosef M., Jannausch M., Jiang Y., Garnero P., et al. Longitudinal changes of serum COMP and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women. Osteoarthritis Cartilage 2009, 17:1609-1614.
24. Garnero P., Aronstein W.S., Cohen S.B., Conaghan P.G., Cline G.A., Christiansen C., et al. Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the knee osteoarthritis structural arthritis randomized clinical trial. Osteoarthritis Cartilage 2008, 16:660-666.
25. Ishijima M., Watari T., Naito K., Kaneko H., Futami I., Yoshimura-Ishida K., et al. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 2011, 13:R22.
26. Lohmander L.S., Atley L.M., Pietka T.A., Eyre D.R. The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 2003, 48:3130-3139.
27. Daniel D.M., Stone M.L., Dobson B.E., Fithian D.C., Rossman D.J., Kaufman K.R. Fate of the ACL-injured patient. A prospective outcome study. Am J Sports Med 1994, 22:632-644.
28. O'Kane J.W., Hutchinson E., Atley L.M., Eyre D.R. Sport-related differences in biomarkers of bone resorption and cartilage degradation in endurance athletes. Osteoarthritis Cartilage 2006, 14:71-76.
29. Niehoff A., Muller M., Bruggemann L., Savage T., Zaucke F., Eckstein F., et al. Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing. Osteoarthritis Cartilage 2011, 19:1003-1010.
30. Kong S.Y., Stabler T.V., Criscione L.G., Elliott A.L., Jordan J.M., Kraus V.B. Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. Arthritis Rheum 2006, 54:2496-2504.
31. Williamson A., Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs 2005, 14:798-804.
32. Hjermstad M.J., Fayers P.M., Haugen D.F., Caraceni A., Hanks G.W., Loge J.H., et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manage 2011, 41:1073-1093.
33. Irrgang J.J., Anderson A.F., Boland A.L., Harner C.D., Kurosaka M., Neyret P., et al. Development and validation of the international knee documentation committee subjective knee form. Am J Sports Med 2001, 29:600-613.
34. Irrgang J.J., Anderson A.F., Boland A.L., Harner C.D., Neyret P., Richmond J.C., et al. Responsiveness of the international knee documentation committee subjective knee form. Am J Sports Med 2006, 34:1567-1573.
35. Anderson A.F., Irrgang J.J., Kocher M.S., Mann B.J., Harrast J.J. The international knee documentation committee subjective knee evaluation form: normative data. Am J Sports Med 2006, 34:128-135.
36. Jung M., Christgau S., Lukoschek M., Henriksen D., Richter W. Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis. Pathobiology 2004, 71:70-76.
37. Mouritzen U., Christgau S., Lehmann H.J., Tanko L.B., Christiansen C. Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 2003, 62:332-336.
38. Nelson F., Billinghurst R.C., Pidoux I., Reiner A., Langworthy M., McDermott M., et al. Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthritis Cartilage 2006, 14:114-119.
39. Dahlberg L., Friden T., Roos H., Lark M.W., Lohmander L.S. A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture - synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1. Br J Rheumatol 1994, 33:1107-1111.
40. Chmielewski T.L. Asymmetrical lower extremity loading after ACL reconstruction: more than meets the eye. J Orthop Sports Phys Ther 2011, 41:374-376.