The role of whole blood impedance aggregometry and its utilisation in the diagnosis and prognosis of patients with systemic inflammatory response syndrome and sepsis in acute critical illness

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Davies, Gareth R ^b   Mills, Gavin M ^a   Lawrence, Matthew ^a,b   Battle, Ceri ^a,c   Morris, Keith ^a,d   Hawkins, Karl ^a,b   Williams, Phylip Rhodri ^e   Davidson, Simon ^f   Thomas, Dafydd ^a,c   Evans, ^a,b  

^a MORRISTON HOSPITAL   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c ABERTAWE BRO MORGANNWG UNIVERSITY HEALTH BOARD   (United Kingdom)

^d CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^e SWANSEA UNIVERSITY   (United Kingdom)

^f ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; COLLAGEN; HEMOGLOBIN; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BLOOD EXAMINATION; CONTROLLED STUDY; CRITICAL ILLNESS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HEMATOCRIT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; PROGNOSIS; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; WHOLE BLOOD IMPEDANCE AGGREGOMETRY; BLOOD; BLOOD CLOTTING TIME; DIAGNOSTIC USE; IMPEDANCE; INTENSIVE CARE UNIT; LEUKOCYTE COUNT; METABOLISM; MIDDLE AGED; PATHOLOGY; SURVIVAL; THROMBOCYTE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ARACHIDONIC ACID; BIOLOGICAL MARKERS; BLOOD PLATELETS; COLLAGEN; CRITICAL ILLNESS; ELECTRIC IMPEDANCE; FEMALE; HEMATOCRIT; HUMANS; INTENSIVE CARE UNITS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET COUNT; PROGNOSIS; PROSPECTIVE STUDIES; SEPSIS; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WHOLE BLOOD COAGULATION TIME;

EID: 84933037396     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108589     Document Type: Article

References (33)

1. Vincent J-L, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, et al. (2006) Sepsis in European intensive care units: Results of the SOAP study. Grit Care Med 34:344-353.
2. Bone R, Balk R, Cerra F, Dellinger R, Fein A, et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101: 1644-1655.
3. Brun-Buisson C (2000) The epidemiology of the systemic inflammatory response. Intensive Care Med 26 Suppl 1: S64- S74.
4. Mavrommatis AC, Theodoridis T, Orfanidou A, Roussos C, ChristopoulouKokkinou V, et al. (2000) Coagulation system and platelets are fully activated in uncomplicated sepsis. Grit Care Med 28: 451-457.
5. Gando S, Nanzaki S, Sasaki S, Aoi K, Kemmotsu O (1998) Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock. Grit Care Med 26: 2005-2009.
6. Dempfle C-E (2004) Coagulopathy of sepsis. Thromb Haemost 91: 213-224.
7. Thiolliere F, Serre-Sapin AF, Reignier J, Benedit M, Constantin JM, et al. (2013) Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study. Intensive Care Med 39: 1460-1468.
8. Gafter-Gvili A, Mansur N, Bivas A, Zemer-Wassercug N, Bishara J, et al. (2011) Thrombocytopenia in Staphylococcus aureus bacteremia: risk factors and prognostic importance. Mayo Clin Proc 86: 389-396.
9. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, et al. (2012) Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. 122: 2661-2671.
10. Sharron M, Hoptay CE, Wiles AA, Garvin LM, Geha M, et al. (2012) Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade. PLoS One 7: e41549.
11. Aslam R, Speck ER, Kim M, Crow AR, Bang KW, et al. (2006) Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood 107: 637-641.
12. Salat A, Murabito M, Boehm D, Bodingbauer G, Pulaki S, et al. (1999) Endotoxin enhances in vitro platelet aggregability in whole blood. Thromb Res 93: 145-148.
13. Zhang G, Han J, Welch EJ, Ye RD, Voyno-Yasenetskaya TA, et al. (2009) Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol 182: 7997-8004.
14. Woth G, Varga A, Ghosh S, Krupp M, Kiss T, et al. (2011) Platelet aggregation in severe sepsis. J Thromb Thrombolysis 31: 6-12.
15. Adamzik M, GörEnger K, Peters J, Hartmann M (2012) Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis. Grit Care 16: R204.
16. Brenner T, Schmidt K, Belang M, Mehrabi a, Bruckner T, et al. (2012) Viscoelastic and aggregometric point-of-care testing in patients with septic shock - cross-links between inflammation and haemostasis. Acta Anaesthesiol Scand 56: 1277-1290.
17. Würtz M, Hvas AM, Kristensen SD, Grove EL (2012) Platelet aggregation is dependent on platelet count in patients with coronary artery disease. Thromb Res 129: 56-61.
18. Hanke AA, Roberg K, Monaca E, Sellmann T, Weber CF, et al. (2010) Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate). Eur J Med Res 15: 214-219.
19. Stissing T, Dridi NP, Ostrowski SR, Bochsen L, Johansson PI (2011) The influence of low platelet count on whole blood aggregometry assessed by Multiplate. Clin Appl Thromb Hemost 17: E211-7.
20. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, et al. (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Grit Care Med 31: 1250-1256.
21. Vincent J, Moreno R, Takala J, Willatts S, de Mendonca A, et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive care Med 22: 707-710.
22. Akobeng AK (2007) Understanding diagnostic tests 3: Receiver operating characteristic curves. Acta Paediatr 96: 644-647.
23. Garraud O, Hamzeh-Cognasse H, Pozetto B, CavaillonJM, Cognasse F (2013) Bench to bedside review: platelets and active immune functions - new clues for immunopathology? Grit Care 17: 236.
24. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, et al. (1998) C40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391: 591-594.
25. Fitzgerald JR, Foster TJ, Cox D (2006) The interactions of bacterial pathogens with platelets. Nat Rev Microbiol 4: 445 157.
26. Ter Avest E, de Jong M, Brümmer I, Wietasch GJ, Ter Maaten JC (2013) Outcome predictors of uncomplicated sepsis. Int J Emerg Med 6: 9.
27. Winning J, Neumann J, Kohl M, Claus RA, Reinhart K, et al. (2010) Antiplatelet drugs and outcome in mixed admissions to an intensive care unit. Grit Care Med 38: 32-37.
28. Winning J, Reichel J, Eisenhut Y, Hamacher J, Kohl M, et al. (2009) Antiplatelet drugs and outcome in severe infection: clinical impact and underlying mechanisms. Platelets 20: 50-57.
29. Baurand A, Eckly A, Bari N, Léon C, Hechler B, et al. (2000) Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors. Thromb Haemost 84: 484-191.
30. Lundahl TH, Petersson J, Fagerberg IH, Berg S, Lindahl TL (1998) Impaired platelet function correlates with multi-organ dysfunction. A study of patients with sepsis. Platelets 9: 223-225.
31. Reggiori G, Occhipinti G, De Gasperi A, Vincent J-L, Piagnerelli M (2009) Early alterations of red blood cell rheology in critically ill patients. Grit Care Med 37: 3041-3046.
32. Kempe DS, Akel A, Lang PA, Hermle T, Biswas R, et al. (2007) Suicidal erythrocyte death in sepsis. J Mol Med (Berl) 85: 273-281.
33. Chiarla C, Giovannini I, Giuliante F, Vellone M, Ardito F, et al. (2010) Significance of hemoglobin concentration in determining blood C02 binding capacity in critical illness. Respir Physiol Neurobiol 172: 32-36.