Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 3, 2015, Pages 2994-3000

  Sun, Xiao Hui ^a   Yang, Li Bin ^a   Geng, Xiao Lin ^a   Wang, Ran ^a   Zhang, Zhi Chang ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

HULC; Long non coding RNAs; Osteosarcoma; Overall survival

Indexed keywords

HULC LONG NON-CODING RNA, HUMAN; LONG UNTRANSLATED RNA; SMALL INTERFERING RNA;

ADOLESCENT; ADULT; BIOSYNTHESIS; BONE TUMOR; CHILD; FEMALE; GENETIC TRANSFECTION; GENETICS; HUMAN; KAPLAN MEIER METHOD; MALE; METASTASIS; MORTALITY; OSTEOSARCOMA; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR INVASION; YOUNG ADULT;

ADOLESCENT; ADULT; BONE NEOPLASMS; CHILD; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; OSTEOSARCOMA; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, LONG NONCODING; RNA, SMALL INTERFERING; TRANSFECTION; YOUNG ADULT;

EID: 84933035304     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Mirabello L, Troisi RJ and Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer 2009; 115: 1531-1543.
2. Hayden JB and Hoang BH. Osteosarcoma: basic science and clinical implications. Orthop Clin North Am 2006; 37: 1-7.
3. Marina N, Gebhardt M, Teot L and Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 2004; 9: 422-441.
4. Kansara M and Thomas DM. Molecular pathogenesis of osteosarcoma. DNA Cell Biol 2007; 26: 1-18.
5. Mattick JS and Makunin IV. Non-coding RNA. Hum Mol Genet 2006; 15 Spec No 1: R17-29.
6. Harries LW. Long non-coding RNAs and human disease. Biochem Soc Trans 2012; 40: 902-906.
7. Mercer TR, Dinger ME and Mattick JS. Long non-coding RNAs: insights into functions. Nature Reviews Genetics 2009; 10: 155-159.
8. Gibb EA, Brown CJ and Lam WL. The functional role of long non-coding RNA in human carcinomas. Mol Cancer 2011; 10: 38.
9. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, Wang Y, Brzoska P, Kong B, Li R, West RB, van de Vijver MJ, Sukumar S and Chang HY. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464: 1071-1076.
10. Zhang EB, Kong R, Yin DD, You LH, Sun M, Han L, Xu TP, Xia R, Yang JS, De W and Chen J. Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget 2014; 5: 2276-2292.
11. Shi X, Sun M, Liu H, Yao Y, Kong R, Chen F and Song Y. A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer. Mol Carcinog 2013; [Epub ahead of print].
12. Hammerle M, Gutschner T, Uckelmann H, Ozgur S, Fiskin E, Gross M, Skawran B, Geffers R, Longerich T, Breuhahn K, Schirmacher P, Stoecklin G and Diederichs S. Posttran scriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). Hepatology 2013; 58: 1703-1712.
13. Prensner JR and Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov 2011; 1: 391-407.
14. Evan GI and Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342-348.
15. Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M and Zatloukal K. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology 2007; 132: 330-342.
16. Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y, Chen N, Sun F and Fan Q. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 2010; 38: 5366-5383.
17. Du Y, Kong G, You X, Zhang S, Zhang T, Gao Y, Ye L and Zhang X. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem 2012; 287: 26302-26311.
18. Zhao Y, Guo Q, Chen J, Hu J, Wang S and Sun Y. Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: a clinical and in vitro investigation. Oncol Rep 2014; 31: 358-364.
19. Peng W, Gao W and Feng J. Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer. Med Oncol 2014; 31: 346.