Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease

Brain Research

Volumn 1605, Issue 1, 2015, Pages 49-58

  Kanamaru, Takuya ^a   Kamimura, Naomi ^a   Yokota, Takashi ^a   Nishimaki, Kiyomi ^a   Iuchi, Katsuya ^a   Lee, Hyunjin ^a   Takami, Shinya ^b   Akashiba, Hiroki ^b   Shitaka, Yoshitsugu ^b   Ueda, Masayuki ^a   Katsura, Ken Ichiro ^a   Kimura, Kazumi ^a   Ohta, Shigeo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; Intravenous transplantation; Mononuclear cell; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MONONUCLEAR CELL; COGNITION; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING; MALE; MEMORY DISORDER; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; TRANSGENIC MOUSE; AMYLOID PLAQUE; ANIMAL; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; COGNITION DISORDERS; DISEASE MODEL; FEMALE; MAZE TEST; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PROCEDURES; PSYCHOLOGY; TRANSPLANTATION;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FEMALE; LEUKOCYTES, MONONUCLEAR; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; PLAQUE, AMYLOID;

EID: 84932610170     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.02.011     Document Type: Article

References (37)

1. Alexander, G., Hanna, A., Serna, V., Younkin, L., Younkin, S., Janus, C., 2011. Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease. Behav. Brain Res. 216, 77-83.
2. Bae, J. S., Jin, H. K., Lee, J. K., Richardson, J. C., Carter, J. E., 2013. Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-beta deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer's disease. Curr. Alzheimer Res. 10, 524-531.
3. Chen, C. H., Ferreira, J. C., Gross, E. R., Mochly-Rosen, D., 2014. Targeting aldehyde dehydrogenase 2: New therapeutic opportunities. Physiol. Rev. 94, 1-34.
4. Conrad, C. D., Lupien, S. J., Thanasoulis, L. C., McEwen, B. S., 1997. The effects of type I and type II corticosteroid receptor agonists on exploratory behavior and spatial memory in the Y-maze. Brain Res. 759, 76-83.
5. Duyckaerts, C., Delatour, B., Potier, M. C., 2009. Classification and basic pathology of Alzheimer disease. Acta Neuropathol. 118, 5-36.
6. Endo, J., Sano, M., Katayama, T., Hishiki, T., Shinmura, K., Morizane, S., Matsuhashi, T., Katsumata, Y., Zhang, Y., Ito, H., Nagahata, Y., Marchitti, S., Nishimaki, K., Wolf, A. M., Nakanishi, H., Hattori, F., Vasiliou, V., Adachi, T., Ohsawa, I., Taguchi, R., Hirabayashi, Y., Ohta, S., Suematsu, M., Ogawa, S., Fukuda, K., 2009. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ. Res. 105, 1118-1127.
7. Hardy, J., Selkoe, D. J., 2002. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
8. Honmou, O., Onodera, R., Sasaki, M., Waxman, S. G., Kocsis, J. D., 2012. Mesenchymal stem cells: therapeutic outlook for stroke. Trends Mol. Med. 18, 292-297.
9. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., Cole, G., 1996. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102.
10. Kamiya, F., Ueda, M., Nito, C., Kamiya, N., Inaba, T., Suda, S., Saito, T., Muraga, K., Katayama, Y., 2014. Effect of repeated allogeneic bone marrow mononuclear cell transplantation on brain injury following transient focal cerebral ischemia in rats. Life Sci. 95, 22-28.
11. Kamiya, N., Ueda, M., Igarashi, H., Nishiyama, Y., Suda, S., Inaba, T., Katayama, Y., 2008. Intra-arterial transplantation of bone marrow mononuclear cells immediately after reperfusion decreases brain injury after focal ischemia in rats. Life Sci. 83, 433-437.
12. Kamiya, N., Ueda, M., Igarashi, H., Nishiyama, Y., Suda, S., Okubo, S., Inaba, T., Katayama, Y., 2013. In vivo monitoring of arterially transplanted bone marrow mononuclear cells in a rat transient focal brain ischemia model using magnetic resonance imaging. Neurol. Res. 35, 573-579.
13. Kim, J. Y., Kim, D. H., Kim, J. H., Lee, D., Jeon, H. B., Kwon, S. J., Kim, S. M., Yoo, Y. J., Lee, E. H., Choi, S. J., Seo, S. W., Lee, J. I., Na, D. L., Yang, Y. S., Oh, W., Chang, J. W., 2012. Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-beta plaques. Cell Death Differ. 19, 680-691.
14. Krafft, G. A., Klein, W. L., 2010. ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology 59, 230-242.
15. Lee, H. J., Lee, J. K., Lee, H., Carter, J. E., Chang, J. W., Oh, W., Yang, Y. S., Suh, J. G., Lee, B. H., Jin, H. K., Bae, J. S., 2012. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol. Aging 33, 588-602.
16. Lee, J. K., Jin, H. K., Endo, S., Schuchman, E. H., Carter, J. E., Bae, J. S., 2010. Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses. Stem Cells 28, 329-343.
17. Lee, S. T., Chu, K., Jung, K. H., Kim, S. J., Kim, D. H., Kang, K. M., Hong, N. H., Kim, J. H., Ban, J. J., Park, H. K., Kim, S. U., Park, C. G., Lee, S. K., Kim, M., Roh, J. K., 2008. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131, 616-629.
18. Ma, T., Gong, K., Ao, Q., Yan, Y., Song, B., Huang, H., Zhang, X., Gong, Y., 2013. Intracerebral transplantation of adiposederived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice. Cell Transplant. 22(Suppl. 1), S113-126.
19. Magga, J., Savchenko, E., Malm, T., Rolova, T., Pollari, E., Valonen, P., Lehtonen, S., Jantunen, E., Aarnio, J., Lehenkari, P., Koistinaho, M., Muona, A., Koistinaho, J., 2012. Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease. J. Cell. Mol. Med. 16, 1060-1073.
20. Moniche, F., Gonzalez, A., Gonzalez-Marcos, J. R., Carmona, M., Pinero, P., Espigado, I., Garcia-Solis, D., Cayuela, A., Montaner, J., Boada, C., Rosell, A., Jimenez, M. D., Mayol, A., Gil-Peralta, A., 2012. Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial. Stroke 43, 2242-2244.
21. Njie, E. G., Kantorovich, S., Astary, G. W., Green, C., Zheng, T., Semple-Rowland, S. L., Steindler, D. A., Sarntinoranont, M., Streit, W. J., Borchelt, D. R., 2012. A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. PLoS One 7, e34097.
22. Ohsawa, I., Nishimaki, K., Murakami, Y., Suzuki, Y., Ishikawa, M., Ohta, S., 2008. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J. Neurosci. 28, 6239-6249.
23. Ohta, S., Ohsawa, I., 2006. Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. J. Alzheimers Dis. 9, 155-166.
24. Orkin, S. H., 2000. Diversification of hematopoietic stem cells to specific lineages. Nat. Rev. Genet. 1, 57-64.
25. Panoskaltsis-Mortari, A., Price, A., Hermanson, J. R., Taras, E., Lees, C., Serody, J. S., Blazar, B. R., 2004. In vivo imaging of graft versus host disease in mice. Blood 103, 3590-3598.
26. Parr, A. M., Tator, C. H., Keating, A., 2007. Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant. 40, 609-619.
27. Pozueta, J., Lefort, R., Shelanski, M. L., 2013. Synaptic changes in Alzheimer's disease and its models. Neuroscience 22, 51-65.
28. Sarnyai, Z., Sibille, E. L., Pavlides, C., Fenster, R. J., McEwen, B. S., Toth, M., 2000. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin (1A) receptors. Proc. Natl. Acad. Sci. U. S. A. 97, 14731-14736.
29. Strauer, B. E., Ran, K. S., 2003. Stem cell therapy in perspective. Circulation 107, 929-934.
30. Suzuki, J., Sasaki, M., Harada, K., Bando, M., Kataoka, Y., Onodera, R., Mikami, T., Wanibuchi, M., Mikuni, N., Kocsis, J. D., Honmou, O., 2013. Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Res. 1497, 15-22.
31. Weissman, I. L., Anderson, D. J., Gage, F., 2001. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403.
32. Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., Ashe, K. H., 2002. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 22, 1858-1867.
33. Xue, S., Chen, C., Dong, W., Hui, G., Liu, T., Guo, L., 2012. Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1DeltaE9-deleted genes. Sci. China Life Sci. 55, 132-140.
34. Yang, B., Migliati, E., Parsha, K., Schaar, K., Xi, X., Aronowski, J., Savitz, S. I., 2013a. Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke. Stroke 44, 3463-3472.
35. Yang, H., Xie, Z., Wei, L., Yang, S., Zhu, Z., Wang, P., Zhao, C., Bi, J., 2013b. Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloidbeta deposition in an AbetaPP/PS1 transgenic mouse model. Stem Cell Res. Ther. 4, 76.
36. Zhang, Y., Yasumizu, R., Sugiura, K., Hashimoto, F., Amoh, Y., Lian, Z., Cherry, Nishio, N., 1994. Fate of allogeneic or syngeneic cells in intravenous or portal vein injection: possible explanation for the mechanism of tolerance induction by portal vein injection. Eur. J. Immunol. 24, 1558-1565.
37. Zilka, N., Zilkova, M., Kazmerova, Z., Sarissky, M., Cigankova, V., Novak, M., 2011. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience 193, 330-337.