Genetic background and risk of postpartum haemorrhage: Results from an Italian cohort of 3219 women

Haemophilia

Volumn 20, Issue 6, 2014, Pages e377-e383

  Biguzzi, Eugenia ^a   Franchi, F ^a   Acaia, B ^a   Ossola, W ^a   Nava, U ^a   Paraboschi, E M ^a   Asselta, Rosanna ^a   Peyvandi, F ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Gene mutations; Haemostasis; Postpartum haemorrhage; Pregnancy

Indexed keywords

ADENINE; BLOOD CLOTTING FACTOR 5; DIPEPTIDYL CARBOXYPEPTIDASE; GLYCOPROTEIN IB ALPHA; GUANINE; PROTHROMBIN; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR; VERY LATE ACTIVATION ANTIGEN 2;

ACE GENE; ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; F2 GENE; F3 GENE; F5 GENE; FEMALE; GENETIC POLYMORPHISM; GP1BA GENE; HEREDITY; HUMAN; ITALIAN (CITIZEN); ITGA2 GENE; MAJOR CLINICAL STUDY; PLACENTA; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; TFPI GENE; VAGINAL DELIVERY; CASE CONTROL STUDY; COHORT ANALYSIS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; ITALY; PHENOTYPE; PREGNANCY; QUANTITATIVE TRAIT LOCUS; RETROSPECTIVE STUDY; RISK;

ADULT; ALLELES; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ITALY; ODDS RATIO; PHENOTYPE; POLYMORPHISM, GENETIC; POSTPARTUM HEMORRHAGE; PREGNANCY; QUANTITATIVE TRAIT LOCI; RETROSPECTIVE STUDIES; RISK;

EID: 84932150951     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/hae.12514     Document Type: Article

References (34)

1. Oyelese Y, Ananth CV. Postpartum hemorrhage: epidemiology, risk factors, and causes. Clin Obstet Gynecol 2010; 53: 147-56.
2. Kominiarek MA, Kilpatrick SJ. Postpartum hemorrhage: a recurring pregnancy complication. Semin Perinatol 2007; 31: 159-66.
3. Ohkuchi A, Onagawa T, Usui R et al. Effect of maternal age on blood loss during parturition: a retrospective multivariate analysis of 10, 053 cases. J Perinat Med 2003; 31: 209-15.
4. Magann EF, Evans S, Hutchinson M, Collins R, Howard BC, Morrison JC. Postpartum haemorrhage after vaginal birth: an analysis of risk factors. South Med J 2005; 98: 419-22.
5. Combs CA, Murphy EL, Laros RK Jr. Factor associated with postpartum hemorrhage with vaginal birth. Obstet Gynecol 1991; 77: 69-76.
6. Usha Kiran TS, Hemmadi S, Bethel J, Evans J. Outcome of pregnancy in a woman with an increased body mass index. BJOG 2005; 112: 768-72.
7. Malkiel A, Pnina M, Aloni H, Gdansky E, Grisaru-Granovsky S. Primiparity: a traditional intrapartum obstetric risk reconfirmed. IMAJ 2008; 10: 508-11.
8. SosaCG, AlthabeF, Belizán J, Buekens P. Risk factors for postpartum hemorrage in vaginal deliveries in a Latin-American population. Obstet Gynecol 2009; 113: 1313-9.
9. Economides DL, Kadir RA, Lee CA. Inherited bleeding disorders in obstetrics and gynaecology. Br J Obstet Gynaecol 1999; 106: 5-13.
10. Bais JM, Eskes M, Pel M, Bonsel GJ, Bleker OP. Postpartum hemorrhage in nulliparous women: incidence and risk factors in low and high risk women. A Dutch 429 population-based cohort study on standard (≥500 ml) and severe (≥1000 mL) postpartum hemorrhage. Eur J Obstet Gynecol Reprod Biol 2004; 115: 166-72.
11. Lu MC, Korst LM, Fridman M, Muthengi E, Gregory KD. Identifying women most likely to benefit from prevention strategies for postpartum hemorrhage. J Perinatol 2009; 29: 422-7.
12. Tuncálp O, Souza JP, Gülmezoglu M. New WHO recommendations on prevention and treatment of postpartum hemorrhage. Int J Gynaecol Obstet 2013; 123: 254-6.
13. Bateman BT1, Berman MF, Riley LE, Leffert LR. The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesth Analg 2010; 110: 1368-73.
14. Sheldon WR1, Blum J, Vogel JP, Souza JP, Gülmezoglu AM, Winikoff B. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG 2014; 121(Suppl 1): 5-13.
15. Arnaud E, Barbalat V, Nicaud V et al. Polymorphisms in the 50regulatory region of the tissue factor gene and the risk of myocardial infarction and venous thromboembolism: the ECTIM and PATHROS studies. Etude Cas-Temoins de l'Infarctus du Myocarde. Paris Thrombosis case-control Study. Arterioscler Thromb Vasc Biol 2000; 20: 892-8.
16. Kunicki T, Kritzik M, Annis DS, Nugent DJ. Hereditary variation in platelet integrin a2b1 density associated with two silent polymorphisms in the a2 gene coding sequence. Blood 1997; 6: 1939-43.
17. Jacquelin B, Tarantino MD, Kritzik M et al. Allele-dependent transcriptional regulation of the human integrin a2 gene. Blood 2001; 97: 1721-6.
18. Reny J-L, Laurendeau I, Fontana P et al. The TF-603 A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers. Thromb Haemost 2004; 91: 248-54.
19. Mannhalter C. Biomarkers for arterial and venous thrombotic disorders. Hamostaseologie 2014; 34: 115-20.
20. Donahue BS, Gailani D, Higgins MS, Drinkwater DC, George AL. Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation 2003; 107: 1003-8.
21. Welsby IJ, Podgoreanu MV, Phillips-Bute B et al. for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genetic factors contribute to bleeding after cardiac surgery. J Thromb Hemost 2005; 3: 1206-12.
22. Clark P, Walker ID, Govan L, Wu O, Greer IA. The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol 2008; 140: 236-40.
23. Kuczyński J1, Uszyński W, Zekanowska E, Soszka T, Uszyński M. Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the placenta and myometrium. Eur J Obstet Gynecol Reprod Biol 2002; 105: 15-9.
24. Nurden AT, Fiore M, Nurden P, Pillois X. Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood 2011; 118: 5996-6005.
25. Biguzzi E, Franchi F, Ambrogi F et al. Risk factors for postpartum hemorrhage in a cohort of 6011 Italian women. Thromb Res 2012; 129: e1-7.
26. Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-75.
27. Wigginton JE, Cutler DJ, Abecasis GR. A Note on exact Tests of Hardy-Weinberg Equilibrium. Am J Hum Genet 2005; 76: 887-93.
28. Lindqvist PG, Dahlbäck B. Carriership of Factor V Leiden and evolutionary selection advantage. Curr Med Chem 2008; 15: 1541-4.
29. Salomon O, Steinberg DM, Pshithizki M et al. The influence of prothrombotic polymorphisms and obstetrical and medical variables on the length of secondary postpartum hemorrhage. J Womens Health 2005; 14: 306-10.
30. Gonzalez-Conejero R, Lozano ML, Rivera J et al. Polymorphisms of platelet membrane glycoprotein Iba associated with arterial thrombotic disease. Blood 1998; 8: 2771-6.
31. Motovska Z, Kvasnicka J, Hajkova J et al. Platelet gene polymorphisms and risk of bleeding in patients undergoing elective coronary angiography: a genetic substudy of the PRAGUE-8 trial. Atherosclerosis 2010; 212: 548-52.
32. Mando C, Antonazzo P, Tabano S et al. Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension. Reprod Sci 2009; 16: 819-26.
33. De Gaetano M, Quacquaruccio G, Pezzini A et al. Tissue factor gene polymorphisms and haplotypes and the risk of ischemic vascular events: four studies and a metaanalysis. J Thromb Haemost 2009; 7: 1465-71.
34. Lockwood CJ, Paidas M, Murk WK et al. Involvement of human decidual cellexpressed tissue factor in uterine hemostasis and abruption. Thromb Res 2009; 124: 516-20.