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Volumn 2015, Issue , 2015, Pages

Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5' NUCLEOTIDASE; ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE PHOSPHATE; CD4 ANTIGEN; ECTO 5' NUCLEOTIDASE; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

EID: 84932102762     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/460610     Document Type: Article
Times cited : (22)

References (42)
  • 1
    • 0034065330 scopus 로고    scopus 로고
    • Acetylcholine receptors and myasthenia
    • J. M. Lindstrom, "Acetylcholine receptors and myasthenia, " Muscle & Nerve, vol. 23, no. 4, pp. 453-477, 2000.
    • (2000) Muscle & Nerve , vol.23 , Issue.4 , pp. 453-477
    • Lindstrom, J.M.1
  • 3
    • 34447503928 scopus 로고    scopus 로고
    • Neuromuscular junction in health and disease
    • N. P. Hirsch, "Neuromuscular junction in health and disease, " British Journal of Anaesthesia, vol. 99, no. 1, pp. 132-138, 2007.
    • (2007) British Journal of Anaesthesia , vol.99 , Issue.1 , pp. 132-138
    • Hirsch, N.P.1
  • 4
    • 0025906606 scopus 로고
    • Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat
    • P. Correia-de-Sá, A. M. Sebastião, and J. A. Ribeiro, "Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat, " British Journal of Pharmacology, vol. 103, no. 2, pp. 1614-1620, 1991.
    • (1991) British Journal of Pharmacology , vol.103 , Issue.2 , pp. 1614-1620
    • Correia-De-Sá, P.1    Sebastião, A.M.2    Ribeiro, J.A.3
  • 5
    • 54049124107 scopus 로고    scopus 로고
    • Adenosine A2 receptor activation inhibits T helper 1 and T helper 2 cell development and effector function
    • B. Csóka, L. Himer, Z. Selmeczy et al., "Adenosine A2 receptor activation inhibits T helper 1 and T helper 2 cell development and effector function, " The FASEB Journal, vol. 22, no. 10, pp. 3491-3499, 2008.
    • (2008) The FASEB Journal , vol.22 , Issue.10 , pp. 3491-3499
    • Csóka, B.1    Himer, L.2    Selmeczy, Z.3
  • 6
    • 6444225887 scopus 로고    scopus 로고
    • Tetanic depression is overcome by tonic adenosine A2A receptor facilitation of L-type Ca2+ influx into rat motor nerve terminals
    • L. Oliveira, M. A. Timóteo, and P. Correia-de-Sá, "Tetanic depression is overcome by tonic adenosine A2A receptor facilitation of L-type Ca2+ influx into rat motor nerve terminals, " Journal of Physiology, vol. 560, no. 1, pp. 157-168, 2004.
    • (2004) Journal of Physiology , vol.560 , Issue.1 , pp. 157-168
    • Oliveira, L.1    Timóteo, M.A.2    Correia-De-Sá, P.3
  • 7
    • 79955666214 scopus 로고    scopus 로고
    • Tetanic failure due to decreased endogenous adenosine A2 tonus operating neuronal Cav1 (L-type) influx in Myasthenia gravis
    • J. B. Noronha-Matos, T. Morais, D. Trigo et al., "Tetanic failure due to decreased endogenous adenosine A2 tonus operating neuronal Cav1 (L-type) influx in Myasthenia gravis, " Journal of Neurochemistry, vol. 117, no. 5, pp. 797-811, 2011.
    • (2011) Journal of Neurochemistry , vol.117 , Issue.5 , pp. 797-811
    • Noronha-Matos, J.B.1    Morais, T.2    Trigo, D.3
  • 8
    • 84860340468 scopus 로고    scopus 로고
    • Activation of the adenosine A2A receptor attenuates experimental autoimmunemyasthenia gravis severity
    • N. Li, L. Mu, J. Wang et al., "Activation of the adenosine A2A receptor attenuates experimental autoimmunemyasthenia gravis severity, " European Journal of Immunology, vol. 42, no. 5, pp. 1140-1151, 2012.
    • (2012) European Journal of Immunology , vol.42 , Issue.5 , pp. 1140-1151
    • Li, N.1    Mu, L.2    Wang, J.3
  • 9
    • 0030878807 scopus 로고    scopus 로고
    • Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion
    • S. Huang, S. Apasov, M. Koshiba, and M. Sitkovsky, "Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion, " Blood, vol. 90, no. 4, pp. 1600-1610, 1997.
    • (1997) Blood , vol.90 , Issue.4 , pp. 1600-1610
    • Huang, S.1    Apasov, S.2    Koshiba, M.3    Sitkovsky, M.4
  • 10
    • 38049141544 scopus 로고    scopus 로고
    • A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
    • P. E. Zarek, C.-T. Huang, E. R. Lutz et al., "A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells, " Blood, vol. 111, no. 1, pp. 251-259, 2008.
    • (2008) Blood , vol.111 , Issue.1 , pp. 251-259
    • Zarek, P.E.1    Huang, C.-T.2    Lutz, E.R.3
  • 11
    • 0029844019 scopus 로고    scopus 로고
    • Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides
    • R. A. Cunha, P. Correia-de-Sá, A. M. Sebastião, and J. A. Ribeiro, "Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides, " British Journal of Pharmacology, vol. 119, no. 2, pp. 253-260, 1996.
    • (1996) British Journal of Pharmacology , vol.119 , Issue.2 , pp. 253-260
    • Cunha, R.A.1    Correia-De-Sá, P.2    Sebastião, A.M.3    Ribeiro, J.A.4
  • 12
    • 0030300123 scopus 로고    scopus 로고
    • Presynaptic A1 inhibitory/A(2A) facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm
    • P. Correia-de-Sá, M. A. Timóteo, and J. A. Ribeiro, "Presynaptic A1 inhibitory/A(2A) facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm, " Journal of Neurophysiology, vol. 76, no. 6, pp. 3910-3919, 1996.
    • (1996) Journal of Neurophysiology , vol.76 , Issue.6 , pp. 3910-3919
    • Correia-De-Sá, P.1    Timóteo, M.A.2    Ribeiro, J.A.3
  • 13
    • 0038511040 scopus 로고    scopus 로고
    • Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at ratmotor nerve endings
    • M. T. Magalhães-Cardoso, M. F. Pereira, L. Oliveira, J. A. Ribeiro, R. A. Cunha, and P. Correia-de-Sá, "Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at ratmotor nerve endings, " Journal of Physiology, vol. 549, no. 2, pp. 399-408, 2003.
    • (2003) Journal of Physiology , vol.549 , Issue.2 , pp. 399-408
    • Magalhães-Cardoso, M.T.1    Pereira, M.F.2    Oliveira, L.3    Ribeiro, J.A.4    Cunha, R.A.5    Correia-De-Sá, P.6
  • 14
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
    • G. Borsellino, M. Kleinewietfeld, D. DiMitri et al., "Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression, " Blood, vol. 110, no. 4, pp. 1225-1232, 2007.
    • (2007) Blood , vol.110 , Issue.4 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    Dimitri, D.3
  • 15
    • 0842300349 scopus 로고    scopus 로고
    • Breakdown of tolerance to a self-peptide of acetylcholine receptor -subunit induces experimentalmyasthenia gravis in rats
    • F. Baggi, A. Annoni, F. Ubiali et al., "Breakdown of tolerance to a self-peptide of acetylcholine receptor -subunit induces experimentalmyasthenia gravis in rats, " Journal of Immunology, vol. 172, no. 4, pp. 2697-2703, 2004.
    • (2004) Journal of Immunology , vol.172 , Issue.4 , pp. 2697-2703
    • Baggi, F.1    Annoni, A.2    Ubiali, F.3
  • 16
    • 0000900192 scopus 로고
    • Adenosine deaminase
    • H. U. Bergmeyer, Ed., Academic Press, New York, NY, USA
    • G. Giusti, "Adenosine deaminase, " in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., pp. 1092-1099, Academic Press, New York, NY, USA, 1974.
    • (1974) Methods of Enzymatic Analysis , pp. 1092-1099
    • Giusti, G.1
  • 17
    • 4344669820 scopus 로고    scopus 로고
    • Adverse effects of myasthenia gravis on rat phrenic diaphragm contractile performance
    • E. Van Lunteren, M. Moyer, andH. J. Kaminski, "Adverse effects of myasthenia gravis on rat phrenic diaphragm contractile performance, " Journal of Applied Physiology, vol. 97, no. 3, pp. 895-901, 2004.
    • (2004) Journal of Applied Physiology , vol.97 , Issue.3 , pp. 895-901
    • Van Lunteren, E.1    Moyer, M.2    Kaminski, A.J.3
  • 18
    • 84884575578 scopus 로고    scopus 로고
    • Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation
    • A. R. Pinheiro, D. Paramos-de-Carvalho, M. Certal et al., "Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation, " The Journal of Biological Chemistry, vol. 288, no. 38, pp. 27571-27583, 2013.
    • (2013) The Journal of Biological Chemistry , vol.288 , Issue.38 , pp. 27571-27583
    • Pinheiro, A.R.1    Paramos-De-Carvalho, D.2    Certal, M.3
  • 19
    • 84856742916 scopus 로고    scopus 로고
    • Coexpression of ecto-5-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver
    • M. Fausther, J. Lecka, E. Soliman et al., "Coexpression of ecto-5-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver, " The American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 302, no. 4, pp. G447-G459, 2012.
    • (2012) The American Journal of Physiology-Gastrointestinal and Liver Physiology , vol.302 , Issue.4 , pp. G447-G459
    • Fausther, M.1    Lecka, J.2    Soliman, E.3
  • 20
    • 0035706374 scopus 로고    scopus 로고
    • Rat models as tool to develop new immunotherapies
    • H. Link and B. G. Xiao, "Rat models as tool to develop new immunotherapies, " Immunological Reviews, vol. 184, pp. 117-128, 2001.
    • (2001) Immunological Reviews , vol.184 , pp. 117-128
    • Link, H.1    Xiao, B.G.2
  • 21
    • 0029246450 scopus 로고
    • Isozyme analysis of the high serum adenosine deaminase activity in patients with myasthenia gravis
    • S. Chiba, M. Saitoh, M. Kashiwagi, N. Kobayashi, and H. Matsumoto, "Isozyme analysis of the high serum adenosine deaminase activity in patients with myasthenia gravis, " Internal Medicine, vol. 34, no. 2, pp. 81-84, 1995.
    • (1995) Internal Medicine , vol.34 , Issue.2 , pp. 81-84
    • Chiba, S.1    Saitoh, M.2    Kashiwagi, M.3    Kobayashi, N.4    Matsumoto, H.5
  • 22
    • 59649099258 scopus 로고    scopus 로고
    • The role of FoxP3+CD4+CD25hi Tregs in the pathogenesis of myasthenia gravis
    • Y. Zhang, H.-B. Wang, L.-J. Chi, and W.-Z. Wang, "The role of FoxP3+CD4+CD25hi Tregs in the pathogenesis of myasthenia gravis, " Immunology Letters, vol. 122, no. 1, pp. 52-57, 2009.
    • (2009) Immunology Letters , vol.122 , Issue.1 , pp. 52-57
    • Zhang, Y.1    Wang, H.-B.2    Chi, L.-J.3    Wang, W.-Z.4
  • 23
    • 0019425025 scopus 로고
    • Role of adenosine deaminase in the early stages of precursor T cell maturation
    • A. Shore, H.-M. Dosch, and E. W. Gelfand, "Role of adenosine deaminase in the early stages of precursor T cell maturation, " Clinical and Experimental Immunology, vol. 44, no. 1, pp. 152-155, 1981.
    • (1981) Clinical and Experimental Immunology , vol.44 , Issue.1 , pp. 152-155
    • Shore, A.1    Dosch, H.-M.2    Gelfand, E.W.3
  • 24
    • 84879190608 scopus 로고    scopus 로고
    • Impairment of regulatory T cells in myasthenia gravis: Studies in an experimentalmodel
    • S. Gertel-Lapter, K. Mizrachi, S. Berrih-Aknin, S. Fuchs, and M. C. Souroujon, "Impairment of regulatory T cells in myasthenia gravis: Studies in an experimentalmodel, " Autoimmunity Reviews, vol. 12, no. 9, pp. 894-903, 2013.
    • (2013) Autoimmunity Reviews , vol.12 , Issue.9 , pp. 894-903
    • Gertel-Lapter, S.1    Mizrachi, K.2    Berrih-Aknin, S.3    Fuchs, S.4    Souroujon, M.C.5
  • 25
    • 68249149171 scopus 로고    scopus 로고
    • Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis
    • L. Mu, B. Sun, Q. Kong et al., "Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis, " Immunology, vol. 128, no. 1, pp. e826-e836, 2009.
    • (2009) Immunology , vol.128 , Issue.1 , pp. e826-e836
    • Mu, L.1    Sun, B.2    Kong, Q.3
  • 26
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • A. Balandina, S. Lécart, P. Dartevelle, A. Saoudi, and S. Berrih-Aknin, "Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis, " Blood, vol. 105, no. 2, pp. 735-741, 2005.
    • (2005) Blood , vol.105 , Issue.2 , pp. 735-741
    • Balandina, A.1    Lécart, S.2    Dartevelle, P.3    Saoudi, A.4    Berrih-Aknin, S.5
  • 27
    • 84856838658 scopus 로고    scopus 로고
    • Alterations in the adenosinemetabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADAdeficient SCID
    • A. V. Sauer, I. Brigida, N. Carriglio et al., "Alterations in the adenosinemetabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADAdeficient SCID, " Blood, vol. 119, no. 6, pp. 1428-1439, 2012.
    • (2012) Blood , vol.119 , Issue.6 , pp. 1428-1439
    • Sauer, A.V.1    Brigida, I.2    Carriglio, N.3
  • 28
    • 72849159656 scopus 로고
    • The changes in the motor end-plate in myasthenia gravis
    • V. Macdermot, "The changes in the motor end-plate in myasthenia gravis, " Brain, vol. 83, no. 1, pp. 24-36, 1960.
    • (1960) Brain , vol.83 , Issue.1 , pp. 24-36
    • Macdermot, V.1
  • 30
    • 33645879218 scopus 로고    scopus 로고
    • Unraveling myasthenia gravis immunopathogenesis using animal models
    • E. Tüzün and P. Christadoss, "Unraveling myasthenia gravis immunopathogenesis using animal models, " Drug Discovery Today: Disease Models, vol. 3, no. 1, pp. 15-20, 2006.
    • (2006) Drug Discovery Today: Disease Models , vol.3 , Issue.1 , pp. 15-20
    • Tüzün, E.1    Christadoss, P.2
  • 31
    • 77951234655 scopus 로고    scopus 로고
    • Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T Cells
    • M. Mandapathil, B. Hilldorfer, M. J. Szczepanski et al., "Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T Cells, " The Journal of Biological Chemistry, vol. 285, no. 10, pp. 7176-7186, 2010.
    • (2010) The Journal of Biological Chemistry , vol.285 , Issue.10 , pp. 7176-7186
    • Mandapathil, M.1    Hilldorfer, B.2    Szczepanski, M.J.3
  • 32
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • S. Deaglio, K. M. Dwyer, W. Gao et al., "Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression, " Journal of Experimental Medicine, vol. 204, no. 6, pp. 1257-1265, 2007.
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.6 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 33
    • 78149484705 scopus 로고    scopus 로고
    • Naturally occurring CD4+CD25+ regulatory T cells prevent but do not improve experimental myasthenia gravis
    • V. Nessi, S. Nava, C. Ruocco et al., "Naturally occurring CD4+CD25+ regulatory T cells prevent but do not improve experimental myasthenia gravis, " Journal of Immunology, vol. 185, no. 9, pp. 5656-5667, 2010.
    • (2010) Journal of Immunology , vol.185 , Issue.9 , pp. 5656-5667
    • Nessi, V.1    Nava, S.2    Ruocco, C.3
  • 34
    • 80055012521 scopus 로고    scopus 로고
    • Localization and function of adenosine receptor subtypes at the longitudinal muscle-myenteric plexus of the rat ileum
    • C. Vieira, F. Ferreirinha, I. Silva, M. Duarte-Araújo, and P. Correia-de-Sá, "Localization and function of adenosine receptor subtypes at the longitudinal muscle-myenteric plexus of the rat ileum, " Neurochemistry International, vol. 59, no. 7, pp. 1043-1055, 2011.
    • (2011) Neurochemistry International , vol.59 , Issue.7 , pp. 1043-1055
    • Vieira, C.1    Ferreirinha, F.2    Silva, I.3    Duarte-Araújo, M.4    Correia-De-Sá, P.5
  • 35
    • 0030007602 scopus 로고    scopus 로고
    • Adenosine uptake and deamination regulate tonic A2 receptor facilitation of evoked 3H acetylcholine release from the rat motor nerve terminals
    • P. Correia-de-Sá and J. A. Ribeiro, "Adenosine uptake and deamination regulate tonic A2 receptor facilitation of evoked 3H acetylcholine release from the rat motor nerve terminals acetylcholine release from the rat motor nerve terminals, " Neuroscience, vol. 73, no. 1, pp. 85-92, 1996.
    • (1996) Neuroscience , vol.73 , Issue.1 , pp. 85-92
    • Correia-De-Sá, P.1    Ribeiro, J.A.2
  • 36
    • 0027048764 scopus 로고
    • Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in bungarotoxin-treated rats
    • J. J. Plomp, G. T. van Kempen, and P. C. Molenaar, "Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in bungarotoxin-treated rats, " Journal of Physiology, vol. 458, pp. 487-499, 1992.
    • (1992) Journal of Physiology , vol.458 , pp. 487-499
    • Plomp, J.J.1    Van Kempen, G.T.2    Molenaar, P.C.3
  • 37
    • 0038131082 scopus 로고    scopus 로고
    • Blockade of neuronal facilitatory nicotinic receptors containing 32 subunits contribute to tetanic fade in the rat isolated diaphragm
    • M. Faria, L. Oliveira, M. A. Timóteo, M. G. Lobo, andP. Correiade-Sá, "Blockade of neuronal facilitatory nicotinic receptors containing 32 subunits contribute to tetanic fade in the rat isolated diaphragm, " Synapse, vol. 49, no. 2, pp. 77-88, 2003.
    • (2003) Synapse , vol.49 , Issue.2 , pp. 77-88
    • Faria, M.1    Oliveira, L.2    Timóteo, M.A.3    Lobo, M.G.4    Correiade-Sá, P.5
  • 38
    • 42449141070 scopus 로고    scopus 로고
    • 31P MR spectroscopic assessment of muscle in patients with myasthenia gravis before and after thymectomy: Initial experience
    • S.-F. Ko, C.-C. Huang, M.-J. Hsieh et al., "31P MR spectroscopic assessment of muscle in patients with myasthenia gravis before and after thymectomy: initial experience, " Radiology, vol. 247, no. 1, pp. 162-169, 2008.
    • (2008) Radiology , vol.247 , Issue.1 , pp. 162-169
    • Ko, S.-F.1    Huang, C.-C.2    Hsieh, M.-J.3
  • 39
    • 0026067737 scopus 로고
    • Sources of adenosine released during neuromuscular transmission in the rat
    • D. O. Smith, "Sources of adenosine released during neuromuscular transmission in the rat, " Journal of Physiology, vol. 432, pp. 343-354, 1991.
    • (1991) Journal of Physiology , vol.432 , pp. 343-354
    • Smith, D.O.1
  • 40
    • 71749095578 scopus 로고    scopus 로고
    • ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle
    • S. Buvinic, G. Almarza, M. Bustamante et al., "ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle, " Journal of Biological Chemistry, vol. 284, no. 50, pp. 34490-34505, 2009.
    • (2009) Journal of Biological Chemistry , vol.284 , Issue.50 , pp. 34490-34505
    • Buvinic, S.1    Almarza, G.2    Bustamante, M.3
  • 41
    • 72249089979 scopus 로고    scopus 로고
    • Nucleoside-5-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5-nucleotidase
    • A. El-Tayeb, J. Iqbal, A. Behrenswerth et al., "Nucleoside-5-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5-nucleotidase, " Journal ofMedicinal Chemistry, vol. 52, no. 23, pp. 7669-7677, 2009.
    • (2009) Journal OfMedicinal Chemistry , vol.52 , Issue.23 , pp. 7669-7677
    • El-Tayeb, A.1    Iqbal, J.2    Behrenswerth, A.3
  • 42
    • 84864881916 scopus 로고    scopus 로고
    • Selective activation of adenosine A2 receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis
    • U. Flögel, S. Burghoff, P. L. E. M. Van Lent et al., "Selective activation of adenosine A2 receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis, " Science Translational Medicine, vol. 4, no. 146, Article ID 146ra108, 2012.
    • (2012) Science Translational Medicine , vol.4 , Issue.146
    • Flögel, U.1    Burghoff, S.2    Van Lent, P.L.E.M.3


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