메뉴 건너뛰기




Volumn 5, Issue 5, 2015, Pages 521-533

Intratumoral heterogeneity in a Trp53-null mouse model of human breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CD24 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 6; PROTEIN P53; STROMAL CELL DERIVED FACTOR 1; TRP53 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; WNT2 PROTEIN; WNT9A PROTEIN; MEMBRANE ANTIGEN;

EID: 84932089510     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-1101     Document Type: Article
Times cited : (54)

References (49)
  • 1
    • 84893064370 scopus 로고    scopus 로고
    • Paracrine signaling in mammary gland development: What can we learn about intratumoral heterogeneity ?
    • Rosen JM, Roarty K. Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity ? Breast Cancer Res 2014; 16: 202.
    • (2014) Breast Cancer Res , vol.16
    • Rosen, J.M.1    Roarty, K.2
  • 2
    • 84893004671 scopus 로고    scopus 로고
    • Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1
    • Forster N, Saladi SV, van Bragt M, Sfondouris ME, Jones FE, Li Z, et al. Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1. Dev Cell 2014; 28: 147-60.
    • (2014) Dev Cell , vol.28 , pp. 147-160
    • Forster, N.1    Saladi, S.V.2    Van Bragt, M.3    Sfondouris, M.E.4    Jones, F.E.5    Li, Z.6
  • 3
    • 34347355444 scopus 로고    scopus 로고
    • Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma
    • Katona TM, Jones TD, Wang M, Eble JN, Billings SD, Cheng L. Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma. Am J Surg Pathol 2007; 31: 1029–37.
    • (2007) Am J Surg Pathol , vol.31 , pp. 1029-1037
    • Katona, T.M.1    Jones, T.D.2    Wang, M.3    Eble, J.N.4    Billings, S.D.5    Cheng, L.6
  • 5
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194: 23-8.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 7
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, et al. Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006; 66: 9339–44.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3    Eaves, C.J.4    Jamieson, C.H.5    Jones, D.L.6
  • 8
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol 2013; 8: 277-302.
    • (2013) Annu Rev Pathol , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 9
    • 84873084388 scopus 로고    scopus 로고
    • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
    • Kreso A, O’Brien CA, van Galen P, Gan OI, Notta F, Brown AM, et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 2013; 339: 543-8.
    • (2013) Science , vol.339 , pp. 543-548
    • Kreso, A.1    O’Brien, C.A.2    Van Galen, P.3    Gan, O.I.4    Notta, F.5    Brown, A.M.6
  • 14
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003; 17: 1253–70.
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3    Jackson, K.W.4    Clarke, M.F.5    Kawamura, M.J.6
  • 16
    • 78049490200 scopus 로고    scopus 로고
    • Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy
    • Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, et al. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med 2010; 2: 55ra79.
    • (2010) Sci Transl Med , vol.2
    • Atkinson, R.L.1    Zhang, M.2    Diagaradjane, P.3    Peddibhotla, S.4    Contreras, A.5    Hilsenbeck, S.G.6
  • 17
    • 77649257221 scopus 로고    scopus 로고
    • Selective targeting of radiationresistant tumor-initiating cells
    • Zhang M, Atkinson RL, Rosen JM. Selective targeting of radiationresistant tumor-initiating cells. Proc Natl Acad Sci U S A 2010; 107: 3522-7.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3522-3527
    • Zhang, M.1    Atkinson, R.L.2    Rosen, J.M.3
  • 18
    • 84860230610 scopus 로고    scopus 로고
    • Dynamic equi librium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations
    • Yang G, Quan Y, Wang W, Fu Q, Wu J, Mei T, et al. Dynamic equi librium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations. Br J Cancer 2012; 106: 1512–9.
    • (2012) Br J Cancer , vol.106 , pp. 1512-1519
    • Yang, G.1    Quan, Y.2    Wang, W.3    Fu, Q.4    Wu, J.5    Mei, T.6
  • 19
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science 2010; 327: 542-5.
    • (2010) Science , vol.327 , pp. 542-545
    • Li, L.1    Clevers, H.2
  • 20
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, et al. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 2008; 68: 4674-82.
    • (2008) Cancer Res , vol.68 , pp. 4674-4682
    • Zhang, M.1    Behbod, F.2    Atkinson, R.L.3    Landis, M.D.4    Kittrell, F.5    Edwards, D.6
  • 21
    • 39149144034 scopus 로고    scopus 로고
    • Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life
    • Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008; 132: 598-611.
    • (2008) Cell , vol.132 , pp. 598-611
    • Morrison, S.J.1    Spradling, A.C.2
  • 23
    • 0036218046 scopus 로고    scopus 로고
    • Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays
    • Cai WW, Mao JH, Chow CW, Damani S, Balmain A, Bradley A. Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol 2002; 20: 393-6.
    • (2002) Nat Biotechnol , vol.20 , pp. 393-396
    • Cai, W.W.1    Mao, J.H.2    Chow, C.W.3    Damani, S.4    Balmain, A.5    Bradley, A.6
  • 24
    • 78650958088 scopus 로고    scopus 로고
    • Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures
    • Fan C, Prat A, Parker JS, Liu Y, Carey LA, Troester MA, et al. Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures. BMC Med Genomics 2011; 4: 3.
    • (2011) BMC Med Genomics , vol.4
    • Fan, C.1    Prat, A.2    Parker, J.S.3    Liu, Y.4    Carey, L.A.5    Troester, M.A.6
  • 25
    • 84887398348 scopus 로고    scopus 로고
    • Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts
    • Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, et al. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol 2013; 14: R125.
    • (2013) Genome Biol , vol.14
    • Pfefferle, A.D.1    Herschkowitz, J.I.2    Usary, J.3    Harrell, J.C.4    Spike, B.T.5    Adams, J.R.6
  • 26
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007; 8: R76.
    • (2007) Genome Biol , vol.8
    • Herschkowitz, J.I.1    Simin, K.2    Weigman, V.J.3    Mikaelian, I.4    Usary, J.5    Hu, Z.6
  • 27
    • 77956628008 scopus 로고    scopus 로고
    • Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    • Zeng YA, Nusse R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture . Cell Stem Cell 2010; 6: 568–77.
    • (2010) Cell Stem Cell , vol.6 , pp. 568-577
    • Zeng, Y.A.1    Nusse, R.2
  • 28
    • 78751522709 scopus 로고    scopus 로고
    • Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    • Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, et al. Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res 2011; 71: 614–24.
    • (2011) Cancer Res , vol.71 , pp. 614-624
    • Liu, S.1    Ginestier, C.2    Ou, S.J.3    Clouthier, S.G.4    Patel, S.H.5    Monville, F.6
  • 29
    • 84887516591 scopus 로고    scopus 로고
    • Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity
    • Gatti M, Pattarozzi A, Bajetto A, Wurth R, Daga A, Fiaschi P, et al. Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity . Toxicology 2013; 314: 209-20.
    • (2013) Toxicology , vol.314 , pp. 209-220
    • Gatti, M.1    Pattarozzi, A.2    Bajetto, A.3    Wurth, R.4    Daga, A.5    Fiaschi, P.6
  • 30
    • 84893830795 scopus 로고    scopus 로고
    • Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity
    • Almendro V, Cheng YK, Randles A, Itzkovitz S, Marusyk A, Ametller E, et al. Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity . Cell Rep 2014; 6: 514-27.
    • (2014) Cell Rep , vol.6 , pp. 514-527
    • Almendro, V.1    Cheng, Y.K.2    Randles, A.3    Itzkovitz, S.4    Marusyk, A.5    Ametller, E.6
  • 32
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features . Proc Natl Acad Sci U S A 2009; 106: 13820-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5    Sjolund, A.6
  • 34
    • 76649128993 scopus 로고    scopus 로고
    • Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
    • Park SY, Gonen M, Kim HJ, Michor F, Polyak K . Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype . J Clin Invest 2010; 120: 636-44.
    • (2010) J Clin Invest , vol.120 , pp. 636-644
    • Park, S.Y.1    Gonen, M.2    Kim, H.J.3    Michor, F.4    Polyak, K.5
  • 36
    • 84907487414 scopus 로고    scopus 로고
    • Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
    • Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 2014; 346: 1248012.
    • (2014) Science , vol.346
    • Clevers, H.1    Loh, K.M.2    Nusse, R.3
  • 37
    • 7944223780 scopus 로고    scopus 로고
    • Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
    • Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, et al. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis . Cancer Cell 2004; 6: 459-69.
    • (2004) Cancer Cell , vol.6 , pp. 459-469
    • Li, Y.M.1    Pan, Y.2    Wei, Y.3    Cheng, X.4    Zhou, B.P.5    Tan, M.6
  • 38
    • 0037237648 scopus 로고    scopus 로고
    • Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
    • Levesque JP, Hendy J, Takamatsu Y, Simmons PJ, Bendall LJ . Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 2003; 111: 187-96.
    • (2003) J Clin Invest , vol.111 , pp. 187-196
    • Levesque, J.P.1    Hendy, J.2    Takamatsu, Y.3    Simmons, P.J.4    Bendall, L.J.5
  • 40
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland . J Clin Invest 2007; 117: 3988-4002.
    • (2007) J Clin Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 41
    • 84865401715 scopus 로고    scopus 로고
    • Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2 + breast cancer by expanding the cancer stem cell population
    • Korkaya H, Kim GI, Davis A, Malik F, Henry NL, Ithimakin S, et al. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2 + breast cancer by expanding the cancer stem cell population . Mol Cell 2012; 47: 570-84.
    • (2012) Mol Cell , vol.47 , pp. 570-584
    • Korkaya, H.1    Kim, G.I.2    Davis, A.3    Malik, F.4    Henry, N.L.5    Ithimakin, S.6
  • 42
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas . J Clin Invest 2007; 117: 3846-56.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3    Pao, W.4    Motoi, N.5    Gerald, W.L.6
  • 43
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells . Cell 2002; 111: 241-50.
    • (2002) Cell , vol.111 , pp. 241-250
    • Van De Wetering, M.1    Sancho, E.2    Verweij, C.3    De Lau, W.4    Oving, I.5    Hurlstone, A.6
  • 44
    • 84864865194 scopus 로고    scopus 로고
    • Non–small cell lung cancer stem/ progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
    • Akunuru S, James Zhai Q, Zheng Y . Non–small cell lung cancer stem/ progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity . Cell Death Dis 2012; 3: e352.
    • (2012) Cell Death Dis , vol.3
    • Akunuru, S.1    James Zhai, Q.2    Zheng, Y.3
  • 45
    • 34948867333 scopus 로고    scopus 로고
    • Further studies on the arrest of cell proliferation in tumor cells at the invading front of colonic adenocarcinoma
    • Rubio CA . Further studies on the arrest of cell proliferation in tumor cells at the invading front of colonic adenocarcinoma . J Gastroenterol Hepatol 2007; 22: 1877-81.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1877-1881
    • Rubio, C.A.1
  • 46
    • 84884559238 scopus 로고    scopus 로고
    • Endocrinetherapy- resistant ESR1 variants revealed by genomic characterization of breast-cancer–derived xenografts
    • Li S, Shen D, Shao J, Crowder R, Liu W, Prat A, et al. Endocrinetherapy- resistant ESR1 variants revealed by genomic characterization of breast-cancer–derived xenografts . Cell Rep 2013; 4: 1116-30.
    • (2013) Cell Rep , vol.4 , pp. 1116-1130
    • Li, S.1    Shen, D.2    Shao, J.3    Crowder, R.4    Liu, W.5    Prat, A.6
  • 47
    • 84897482887 scopus 로고    scopus 로고
    • Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers
    • Cleary AS, Leonard TL, Gestl SA, Gunther EJ . Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers . Nature 2014; 508: 113-7.
    • (2014) Nature , vol.508 , pp. 113-117
    • Cleary, A.S.1    Leonard, T.L.2    Gestl, S.A.3    Gunther, E.J.4
  • 49
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • Wang Y, Waters J, Leung ML, Unruh A, Roh W, Shi X, et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing . Nature 2014; 512: 155-60.
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1    Waters, J.2    Leung, M.L.3    Unruh, A.4    Roh, W.5    Shi, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.