Pharmacogenomics of hypertension: A genome-wide, placebo-controlled cross-over study, using four classes of antihypertensive drugs

Journal of the American Heart Association

Volumn 4, Issue 1, 2015, Pages

  Hiltunen, Timo P ^a   Donner, Kati M ^a   Sarin, Antti Pekka ^a   Saarela, Janna ^a   Ripatti, Samuli ^a,b   Chapman, Arlene B ^c,d   Gums, John G ^e,f   Gong, Yan ^e   Cooper DeHoff, Rhonda M ^e,g   Frau, Francesca ⁱ   Glorioso, Valeria ^j   Zaninello, Roberta ^j   Salvi, Erika ⁱ   Glorioso, Nicola ^j   Boerwinkle, Eric ^h,k   Turner, Stephen T ^c   Johnson, Julie A ^e   Kontula, Kimmo K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c MAYO CLINIC   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Center for Pharmacogenomics   (United States)

^f Departments of Psychiatry Neuroscience Anesthesiology Community Health Family Medicine   (United States)

^g School of Pharmacy   (United States)

^h UNIVERSITY OF FLORIDA   (United States)

ⁱ UNIVERSITY OF MILAN   (Italy)

^j UNIVERSITY HOSPITAL OF SASSARI   (Italy)

^k UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

more..

Author keywords

Antihypertensive drug; Association study; Drug response; Genome wide; Hypertension

Indexed keywords

AMLODIPINE; BISOPROLOL; HYDROCHLOROTHIAZIDE; LOSARTAN; NEPHRIN; PLACEBO; ACTIN BINDING PROTEIN; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE (NAD(P)+); ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; CANDESARTAN; CHLORIDE CHANNEL; CLIC5 PROTEIN, HUMAN; MEMBRANE PROTEIN; TETRAZOLE DERIVATIVE;

ACY3 GENE; ADULT; ALDH1A3 GENE; ARTICLE; CHROMOSOME 11; CLIC5 GENE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; GENE; GENE IDENTIFICATION; GENE LOCATION; GENETIC ASSOCIATION; GENOTYPING TECHNIQUE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NPHS1 GENE; PHARMACOGENOMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TREATMENT RESPONSE; BLOOD PRESSURE MONITORING; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; ESSENTIAL HYPERTENSION; FINLAND; GENETICS; GENOME-WIDE ASSOCIATION STUDY; META ANALYSIS (TOPIC); MIDDLE AGED; PHARMACOGENETICS; PROCEDURES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ADULT; ALDEHYDE OXIDOREDUCTASES; AMLODIPINE; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; BISOPROLOL; BLOOD PRESSURE MONITORING, AMBULATORY; CHLORIDE CHANNELS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ESSENTIAL HYPERTENSION; FINLAND; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; LOSARTAN; MALE; MEMBRANE PROTEINS; META-ANALYSIS AS TOPIC; MICROFILAMENT PROTEINS; MIDDLE AGED; MUTATION, MISSENSE; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; TETRAZOLES; TREATMENT OUTCOME;

EID: 84931841427     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.001521     Document Type: Article

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